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In a Nutshell * An oral compound called TOFA caused significant weight and fat loss in obese mice without reducing food intake or causing muscle loss, setting it apart from current obesity drugs. * TOFA worked by boosting how much energy cells burn, rather than suppressing appetite, and it also improved blood sugar, harmful blood fats, and fatty liver disease. * When combined with semaglutide or tirzepatide, TOFA outperformed either drug alone, and animals maintained their weight loss longer after TOFA treatment ended compared to semaglutide. ============================================================================================== Millions of Americans struggling with obesity have placed their hopes in a new...

Drugs prescribed for diabetes and chronic obesity such as Ozempic are increasingly sought after for quick, cosmetic weight loss, a life choice pharmacists warn can lead to serious health risks. “We have seen thin people try to come in and get it,” Dr. Carrie Leske, a licensed pharmacist in Minnesota, recently told Just the News. “As pharmacists we are supposed to use our judgment and, if need be, call the physician and try to understand what's going on, because it's supposed to only be used for obese people.” Such prescription medications, known under such popular brand names as Ozempic and...

Key Points Eli Lilly said its next-generation drug cleared a crucial late-stage trial in patients with obesity, delivering significant weight loss across doses. The results bring Lilly one step closer to filing for approval of the weekly injection, called retatrutide, which works differently from existing injections and pills. The highest dose of retatrutide helped patients lose 28.3% of their weight — or 70.3 pounds — on average over 80 weeks. ==================================================================== VIDEO AT LINK........ Eli Lilly on Thursday said its next-generation drug cleared a crucial late-stage trial in patients with obesity, delivering significant weight loss across doses. The results bring...

The therapy, marketed as Zepbound and Mounjaro, took the crown from Merck at a striking paceMerck, which has claimed bragging rights as the maker of the world’s best-selling drug, Keytruda, since 2023, has officially been surpassed by Eli Lilly. Lilly’s tirzepatide, marketed as Mounjaro for type 2 diabetes and Zepbound for obesity, saw $10.1 billion in sales in the third quarter, the pharma giant said Thursday, bringing year-to-date sales of the product to $24.8 billion. Merck, meanwhile, reported that Keytruda, a cancer immunotherapy, earned $8.1 billion in the third quarter, bringing year-to-date sales to $23.3 billion. Tirzepatide took the crown...

NEW YORK, May 21 (Reuters) - Cigna (CI.N), opens new tab will cap out-of-pocket costs at $200 per month for patients using the weight-loss drugs Wegovy and Zepbound through an add-on to its pharmacy benefit management plans, the company announced on Wednesday. Cigna's pricing compares to the cash-pay market for weight-loss drugs, said Harold Carter, a senior vice president at Evernorth. The drugs, from Novo Nordisk (NOVOb.CO), opens new tab and Eli Lilly (LLY.N), opens new tab, have list prices that reach $1,000 but are available for about half that or less on the manufacturers' websites.

The drug tirzepatide improved kidney function and cardiovascular outcomes among patients with obesity and heart failure with preserved ejection fraction (HFpEF) compared with placebo at one year, according to featured clinical research. In the new analysis of data from the SUMMIT trial, researchers focused on patients with obesity, chronic kidney disease and HFpEF. HFpEF occurs when the heart muscle cannot enlarge sufficiently to accommodate the blood it receives, causing pressure in the heart to become elevated. Chronic kidney disease occurs when the kidneys do not filter waste from the blood as they should, leading to a buildup of toxins. Tirzepatide...