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Call it a new type of precision medicine. A researcher says one day oncologists may be able to write personalized exercise "prescriptions" for cancer patients that suppress tumor growth. Jay Taylor helped develop a mathematical model that attempts to quantify the relationship between exercise, immune function and cancer. The paper looked at models of mice running on wheels to show that increases in exercise intensity and duration decrease the proliferation of malignant cells. According to the paper, the team worked on a mathematical model to describe the transition of natural killer cells from inactive to active states due to exercise-induced...

Allergic diseases such as asthma, atopic dermatitis, and food allergies have been increasing in frequency over the last few years. They are typically caused by the immune system being hypersensitive to harmless substances in foods and the environment. Flavonoids are chemicals present in various fruits and vegetables that are known to have anti-allergic effects and show promise as natural allergic treatments. To better understand how these allergies can be treated, let's look at an interesting anti-allergic mechanism in our cells. In the intestines, specialized dendritic cells (DCs) produce an enzyme called RALDH2 (retinaldehyde dehydrogenase 2) which converts retinal, a chemical...

Salt could help to boost the immune defense against cancer. This is suggested by research findings. Recently, adoptive T-cell therapy in particular has developed into an effective treatment tool. In adoptive T-cell therapy, the patient's own immune cells (T cells) are isolated from the blood and modified and multiplied in the laboratory in a therapy-specific manner. They are then reinfused into the patient and destroy tumor cells. The team has now discovered one of these factors: Sodium ions—a component of sodium chloride—increase the efficiency of antitumoral T cells. The researchers were able to show that breast cancer tumors have a...

·"The Fountain of Youth" 1546. By Lucas Cranach the Elder - Unknown source, Public Domain, https://commons.wikimedia.org/w/index.php?curid=30264218 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ A biomedical sciences professor studying T-cells and their effect on cellular senescence believes she may have found a real-life fountain of youth hiding within our own bodies. Although still in the development stages, the professor’s pioneering method may indeed increase health and “reverse” aging for older patients while also preventing aging-related declines in younger patients. HUMANITY’S ENDURING QUEST FOR THE FOUNTAIN OF YOUTH The idea of a Fountain of Youth that could reverse aging and help people stay young indefinitely was made most...

An article demonstrates the beneficial effects of consuming 500 milligrams (mg) per day of propolis for people living with HIV, the virus that causes AIDS. The authors found that the group given propolis, unlike the group given placebo, displayed a significant reduction in plasma levels of malondialdehyde, a marker of oxidative stress. Total antioxidant capacity increased slightly in the same group, reflecting the direct combating of free radicals. "Although people living with HIV have excellent life expectancy, one of the problems still faced is the question of premature aging," said biologist Karen Ingrid Tasca. This process of premature aging is...

he mRNA vaccines were released globally in early 2021 with the slogan ‘safe and effective.’ Unusually for a new class of medicine, they were soon recommended by public health authorities for pregnant women. By late 2021, working-age women, including those who were pregnant, were being thrown out of employment for not agreeing to be injected. Those who took the mRNA vaccines did so based on trust in health authorities – the assumption being that they would not have been approved if the evidence was not absolutely clear. The role of regulatory agencies was to protect the public and, therefore, if...

A team of scientists from Scripps Research and the University of North Carolina (UNC) has found antibodies in the blood of certain COVID-19 donors that can block infection from a broad set of coronaviruses—specifically, in people who have recovered from the virus and were then vaccinated. They found this includes not only the COVID-19-causing SARS-CoV-2, but also SARS-CoV-1 and MERS-CoV. The scientists' detailed study of the antibodies and their virus binding sites, reported on February 15, 2023, in the journal Immunity, could lead to the development of a broad coronavirus vaccine and related antibody therapeutics. Both could be used against...

Urolithin A, a metabolite of ellagitannins in pomegranates, boosts immune cells’ ability to combat tumors by inducing a process known as mitophagy. STORY AT-A-GLANCE Urolithin A (UA) has emerged as a powerhouse player in the fight against cancer, as it may naturally boost tumor-fighting immune cells. UA is a metabolite of ellagitannins in pomegranates that has anti-inflammatory and anticancer effects. UA “recycles and renews mitochondria” by inducing a biological pathway known as mitophagy—the process of cleaning out your mitochondria, allowing them to function at their best. This changes T cells’ genetic program, making them more able to fight tumors. In...

SCIENTISTS are working on a cancer vaccine which will be personalised for individual patients. The new jab will be used to treat treat patients with high-risk melanoma - the deadliest form of skin cancer. Manufacturers Moderna and Merck have said results of the trial, which will determine whether it stops cancer coming back, are expected by the end of the year. The experimental vaccine is based of of the same messenger RNA (mRNA) technology that was used to create the revolutionary Covid vaccines. The cancer shot is tailored for each patient to generate T-cells - a key part of the...

The level of magnesium in the blood is an important factor in the immune system's ability to tackle pathogens and cancer cells. Researchers from have reported that T cells need a sufficient quantity of magnesium in order to operate efficiently. Their findings may have important implications for cancer patients. Magnesium deficiency is associated with a variety of diseases, such as infections and cancer. Previous studies have shown that cancerous growths spread faster in the bodies of mice when the animals received a low-magnesium diet—and that their defense against flu viruses was also impaired. However, there has so far been little...

A type of cells produced by the body when fighting common cold viruses cross-protect people against infection with the virus that causes COVID-19, according to a study published Monday.A 3D print of a spike protein of SARS-CoV-2—the virus that causes COVID-19—in front of a 3D print of a SARS-CoV-2 virus particle. (Courtesy of NIAID/RML)T cells have been recognized as a measure of protection against severe COVID-19 and previous research indicated that recovery from common colds may provide some level of shielding against the virus that causes COVID-19.Researchers with Imperial College London found in the new study that the presence of...

Common compounds produced by gut microbes quench colitis in mice Common molecules made by bacteria in the gut may act as chill pills for the immune system. Molecules secreted by intestinal bacteria work to prevent misplaced immune attacks in inflammatory bowel diseases like colitis, a new study finds. “It is a huge advance,” says Sarkis Mazmanian of Caltech. “This opens up the notion that a very easy and potentially very safe therapy for inflammatory bowel disease could exist.” Decades of research have hinted that microbes play a role in immune-related diseases such as obesity, allergy, inflammatory bowel disease and colon...

Following the results of the ENSEMBLE 2 study, which demonstrated improved vaccine efficacy of a two-dose regimen of Ad26.COV.2 vaccine given 2 months apart, we expanded the Sisonke study which had provided single dose Ad26.COV.2 vaccine to almost 500 000 health care workers (HCW) in South Africa to include a booster dose of the Ad26.COV.2. Sisonke 2 enrolled 227 310 HCW from the 8 November to the 17 December 2021. Enrolment commenced before the onset of the Omicron driven fourth wave in South Africa affording us an opportunity to evaluate early VE in preventing hospital admissions of a homologous boost...

FDA and CDC experts said the plan was ill-advised, so the agencies cut them out of the decision process.. The U.S. government is pushing Covid-19 vaccine boosters for 16- and 17-year-olds without supporting clinical data. A large Israeli population study, published in the New England Journal of Medicine earlier this month, found that the risk of Covid death in people under 30 with two vaccine shots was zero. Booster mandates for healthy young people, which some colleges are imposing, will cause medical harm for the sake of transient reductions in mild and asymptomatic infections. In a study of 438,511 males...

Hosted by UK Column, last Friday Doctors for Covid Ethics (“D4CE”) held their second symposium, “Sounding the Call.” The symposium comprised 15 experts in science, medicine, finance, media, and the law who spoke as they should – freely and honestly.In September two pathologists, Prof. Arne Burkhardt and Prof. Walter Yang, released their findings of an investigation into ten deaths linked to Covid injections. “The lymphocytes are running amok in all organs,” Professor Yang said. During D4CE’s Symposium II, Prof. Burkhardt revealed the findings on 20 deaths post-injection which confirmed their previous findings. “This ‘lymphocytic amok’ is a very alarming finding,”...

We found that the spike protein localizes in the nucleus and inhibits DNA damage repair.’. A Swedish lab study released in mid-October found that the spike protein associated with the COVID-19 illness, and its experimental vaccines, enters the nucleus of cells and significantly interferes with DNA damage-repair functions compromising a person’s adaptive immunity and perhaps encouraging the formation of cancer cells. The study, titled “SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro,” was released by the Department of Molecular Biosciences of Stockholm University, and began by discussing the enormous impact of the COVID-19 disease on the...

[H/T LilFarmer]ransomnote: the video and transcript below feature Dr. Ryan Cole, a board-certified pathologist and owner/operator of a diagnostics lab, reporting to the public in a video produced by Idaho state government’s “Capitol Clarity” project.https://twitter.com/i/status/1430589141344034816Begin Transcript:Dr. Cole: "But what we’re seeing in the laboratory after people get these shots, we’re seeing a very concerning locked in low-profile of these important killer T-cells that you want in your body. It’s almost a reverse HIV.In HIV you’ll lose your Helper T Cells (i.e., CD4 cells).In this virus, post vaccine, what we’re seeing is is a drop in your Killer T cells (i.e.,...

Study Shows Vaccine Will ENHANCE Delta InfectivitySTORY AT-A-GLANCEA group of Japanese researchers released research showing that the SARS-CoV-2 Delta variant “is poised to acquire complete resistance” to existing COVID-19 jabs When four common mutations were introduced to the Delta variant, Pfizer’s mRNA injection enhanced its infectivity, causing it to become resistant A Delta variant with three mutations has already emerged, which suggests it’s only a matter of time before a fourth mutation develops, at which point complete resistance to Pfizer’s jab may be imminent A number of experts have raised concerns that COVID-19 jabs and the mass vaccination program could...

Mount Sinai researchers have found an important clue to a rare but serious aftereffect of COVID-19 in children, known as multisystem inflammatory syndrome in children or MIS-C. The researchers reported that RNA sequencing of blood samples from the Mount Sinai COVID-19 Biobank led to the discovery that specific infection-fighting cells of the immune system are downregulated in children with MIS-C, and that this is associated with a sustained inflammatory response, a hallmark of infection with SARS-CoV-2, the virus that causes COVID-19. The study was published in Nature Communications on August 11, 2021. MIS-C is characterized by fever, pain, and inflammation...

Abstract The immune response to SARS-CoV-2 is critical in controlling disease, but there is concern that waning immunity may predispose to reinfection. We analyzed the magnitude and phenotype of the SARS-CoV-2-specific T cell response in 100 donors at 6 months following infection. T cell responses were present by ELISPOT and/or intracellular cytokine staining analysis in all donors and characterized by predominant CD4+ T cell responses with strong interleukin (IL)-2 cytokine expression. Median T cell responses were 50% higher in donors who had experienced a symptomatic infection, indicating that the severity of primary infection establishes a ‘set point’ for cellular immunity....