"Paul bravely and privately fought cancer for years with his trademark tenacity and wit. A gifted and prolific talent, he will forever live in the comedy pantheon and in our hearts as a treasured friend and man of remarkable character and generosity of spirit." Reubens starred in the the 1985 film "Pee-wee's Big Adventure"; on the television show "Pee-wee's Playhouse," which ran from 1986 to 1990; and in the 1988 film sequel "Big Top Pee-wee." He performed as a voice actor on several other TV shows. Reubens was also a stand-up comedian.