In an international, multicenter Phase II clinical trial led by The University of Texas MD Anderson Cancer Center, 63.3% of patients with stage II–IV cutaneous squamous cell carcinoma (CSCC) saw their tumors nearly or completely disappear when treated with immunotherapy before surgery. The anti-PD1 therapy cemiplimab was well-tolerated, and the study met its primary endpoint with a pathologic complete response (pCR) rate of 50.6%, meaning no tumor cells were found at surgery. Another 12.7% of patients had a major pathological response (MPR), with less than 10% viable tumor found at surgery. The responses were confirmed by independent central pathologic review....