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Keyword: prostate

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  • King Charles III diagnosed with cancer, Buckingham Palace says

    02/05/2024 10:05:53 AM PST · by rdl6989 · 289 replies
    BBC ^ | Feb 5, 2024 | Sean Coughlan
    King Charles has been diagnosed with a form of cancer, says Buckingham Palace. It is not prostate cancer, but was discovered during his recent treatment for an enlarged prostate. The type of cancer has not been revealed, but according to a palace statement the King began "regular treatments" on Monday. Buckingham Palace says the King "remains wholly positive about his treatment and looks forward to returning to full public duty as soon as possible".
  • New therapeutic strategy for metastatic prostate cancer patients resistant to standard treatment (Kinase inhibitors to overcome docetaxel resistance)

    02/03/2024 7:36:44 PM PST · by ConservativeMind · 1 replies
    A team of researchers have found a new therapeutic strategy for patients with a specific subtype of metastatic prostate cancer resistant to standard chemotherapy treatment with docetaxel. In this study, they propose a new treatment based on a combination of kinase inhibitors in patients who inevitably stop responding to docetaxel. The team found that resistance to this drug is associated with the hyperactivation of the cellular pathways PI3K/AKT and MEK/ERK and have explored the possibility of inhibiting these pathways as a new therapeutic strategy in patients who maintain the function of PTEN, a negative regulatory protein of the PI3K/AKT pathway....
  • Clinical trial finds combination hormone therapy delivers superior prostate cancer treatment (For high risk, relapsed cancer)

    01/28/2024 8:11:32 PM PST · by ConservativeMind · 4 replies
    Combining testosterone-blocking drugs in patients with prostate cancer relapse prevents the spread of cancer better than treatment with a single drug, a multi-institution, Phase 3 clinical trial led by researchers has found. The approach can extend the time between debilitating drug treatments without prolonging the time it takes to recover from each treatment. Prostate cancer is usually treated with one of several testosterone-lowering drugs for a set period of time. "This adds to a growing body of evidence in favor of more intensive testosterone-blocking therapy in patients with higher-risk prostate cancer," said Rahul Aggarwal, MD. The new study focused on...
  • Protein discovery could help solve prostate cancer drug resistance (“Dramatic” effect from $10 a month drug (dicyclomine))

    01/28/2024 8:45:23 PM PST · by ConservativeMind · 2 replies
    Researchers have identified a receptor protein known as CHRM1 as a key player in prostate cancer cells' resistance to docetaxel, a commonly-used chemotherapy drug to treat advanced cancer that has spread beyond the prostate. The discovery opens the door to new treatment strategies that could overcome this resistance. The study showed that blocking CHRM1 in resistant prostate cancer cell lines and an animal model based on patient-derived resistant tissue restored docetaxel's ability to kill cells and stop tumor growth. The researchers did this by using dicyclomine, a drug that selectively inhibits CHRM1 activity. Dicyclomine is already on the market as...
  • Awkward blunder for US Today Show as closed caption reads King Charles is to undergo 'prostitute surgery'

    01/23/2024 7:41:57 AM PST · by dynachrome · 24 replies
    Daily Mail ^ | 1-23-24 | BRIDIE PEARSON-JONES
    The Today Show suffered an awkward blunder on Monday as it's closed captions said King Charles was set to undergo 'prostitute surgery'. The highly-watched US morning show, which airs on NBC, was reporting on the king's recent surgery for an enlarged prostate. But instead of reporting about the medical procedure, the caption read the king was to have 'prostitute surgery'. The blunder was spotted by Below Deck and the Traitors US star Kate Chastain who uploaded it to Instagram and joked 'I bet AI is in charge of closed captions for the Today Show'. Last week the royal was diagnosed...
  • Advanced Prostate Cancer Cases on the Rise After Years of Decline: What You Need to Know

    01/12/2024 8:25:26 AM PST · by george76 · 51 replies
    Epoch Times ^ | 1/12/2024 | Cara Michelle Miller
    U.S. Defense Secretary Lloyd Austin was recently diagnosed and is being treated for prostate cancer. He is one of the nearly 290,000 American men who will be diagnosed with the condition this year. Nearly all types of cancer have become less deadly over the last 30 years, with one notable exception: advanced-stage prostate cancer, according to a recent report from the American Cancer Society (ACS). “We have had more men diagnosed with more advanced prostate cancer over the last decade,” Dr. Sam S. Chang, the Chief Surgical Officer at the Vanderbilt Ingram Cancer Center, told The Epoch Times in an...
  • Defense Secretary Lloyd Austin diagnosed with prostate cancer

    01/09/2024 11:55:32 AM PST · by Yossarian · 44 replies
    NBC News on MSN ^ | 1/9/24 | Courtney Kube and Rebecca Shabad
    Defense Secretary Lloyd Austin was diagnosed with prostate cancer in December and underwent a minimally invasive procedure to treat and cure it, according to a statement from Walter Reed National Military Center officials on Tuesday. "Secretary Austin recovered uneventfully from his surgery and returned home the next morning. [snipped out section quoting officials saying his prognosis is excellent] Austin was then admitted to Walter Reed on Jan. 1 "with complications from the December 22 procedure, including nausea with severe abdominal, hip, and leg pain," the officials said.
  • A naturally-occurring molecule shows promise as effective first-line treatment for prostate cancer (Carnosine)

    Scientists wanted to investigate the anti-cancer properties of carnosine against cells derived from both primary and metastatic prostate cancer. Carnosine, which can be produced by the body and is also found in meat, has long been advocated for use as an antioxidant to facilitate healthy aging. There have been reports of carnosine being effective against the development of a number of different cancers but this is the first time it has been studied in relation to prostate cancer. The researchers found that carnosine stopped the cells from multiplying and at higher doses even killed cancer from both primary and metastatic...
  • Bone scans overstage prostate cancer at initial staging compared with PSMA PET: Study (Bone scans falsely show metastasis)

    11/14/2023 8:27:50 PM PST · by ConservativeMind · 3 replies
    Bone scans have been found to overstage prostate cancer at initial staging compared to prostate-specific membrane antigen (PSMA) PET, according to new research. The significant false-positive rate of metastases on bone scans means that definitive therapy for local disease may have been withheld from patients inappropriately. PSMA PET is more accurate than CT and bone scans for staging patients with prostate cancer and, in recent years, has become the standard imaging modality at initial staging. Nearly all prostate cancer trials have used CT and bone scans for staging, however, and the best way to apply those data to patients staged...
  • A new connection between the gut microbiota and prostate inflammation in aging men

    11/11/2023 10:31:20 PM PST · by ConservativeMind · 13 replies
    Medical Xpress / Impact Journals LLC / Aging ^ | Nov. 8, 2023 | Weronika Ratajczak et al
    Recent studies indicate that inflammation is one of the causes of the development of benign prostatic hyperplasia (BPH). Inflammation may result from past infections, metabolic disorders, but also from the state of functioning of the intestinal microbiota. In this new study, researchers aimed to assess whether the diagnostic lipid parameters for metabolic syndrome and short-chain fatty acids (SCFAs) are related to the immunoexpression of interleukins in prostate tissue with benign hyperplasia. The study involved 103 men with BPH, who were divided into two groups depending on the presence of MetS. "We analyzed tissue immunoexpression of two proinflammatory interleukins: IL-6, which...
  • Prostate Problems

    11/10/2023 8:01:10 AM PST · by far sider · 83 replies
    I am a 250-lb, 6-foot, 65 year-old Freeper from southern Ohio. I have been on 80 mg FloMax since summer and I don't like it. And it doesn't seem to work that well. I have seen that there are several different surgical options. I would appreciate anyone who could share their experience and/or advice. Thanks.
  • Study sheds light on diabetes drug for prostate cancer (Metformin could help up to 60% of new cases)

    11/09/2023 10:04:27 PM PST · by ConservativeMind · 16 replies
    A study suggests metformin is a drug that could prevent the progression of prostate cancer, but only for tumors with low levels of NKX3.1, which are more likely to develop into aggressive cancers. The researchers found metformin restores cancer-fighting mitochondrial activity that is lost when NKX3.1 levels are low, prevents prostate cancer progression in mice, and is associated with better survival in patients with low-NKX3.1 tumors but not high-NKX3.1 tumors. Papachristodoulou found that when prostate cells are under oxidative stress (as happens during prostate cancer development), NKX3.1 moves into the cells' mitochrondria to reduce stress and protect the cells. If...
  • Docetaxel use associated with significant reduction in prostate cancer death in very poor prognostic group (70% reduction in deaths)

    11/04/2023 9:56:43 AM PDT · by ConservativeMind · 9 replies
    Men with high-grade prostate cancer and low prostate-specific antigen (PSA) levels have a poor prognosis. The question remains as to whether the chemotherapy drug docetaxel, which increases survival in metastatic prostate cancer, can improve the cure rate in these patients. In a new study by investigators from Brigham and Women's Hospital, a meta-analysis of five prospective randomized clinical trials (RCTs) found that adding docetaxel to standard-of-care (SOC) treatment was associated with a 70% reduction in death from prostate cancer-specific mortality (PCSM). Investigators performed a meta-analysis of the RCTs evaluating SOC treatment with radiotherapy and androgen deprivation therapy or with radical...
  • Minimally invasive transperineal laser ablation of the prostate appears effective

    10/08/2023 8:00:04 AM PDT · by ConservativeMind · 8 replies
    Medical Xpress / HealthDay / Therapeutic Advances in Urology ^ | Oct. 3, 2023 | Lori Solomon / Lazaros Tzelves et al
    Minimally invasive transperineal laser ablation (TPLA) of the prostate appears effective for benign prostatic hyperplasia (BPH), according to a review. Lazaros Tzelves and colleagues conducted a systematic literature review to examine the safety and efficacy of TPLA for BPH. Based on 11 included studies, the researchers found that functional outcomes were improved in the majority of studies both for objective (maximum flow rate and postvoid residual) and subjective outcomes (improvement of International Prostate Symptom Score and quality of life). Complications included hematuria (range: 1.9 to 2.3 percent), dysuria (3.7 to 36.3 percent), acute urinary retention (1.9 to 19 percent), orchitis/urinary...
  • Doctor Diagnosed With Advanced Prostate Cancer Learns Lessons on Death, Dying and Compassion

    08/29/2023 10:56:35 PM PDT · by nickcarraway · 18 replies
    Today Online ^ | August 5, 2023 | Eveline Gan
    Having dedicated more than three decades of his career to the field of urology focused on prostate cancer, Professor Christopher Cheng was aware of the sobering possibility that he may eventually succumb to the very same disease he knows well as a specialist. In 2017, the urologist and trailblazer in the use of robots for surgery found himself on the other side of the treatment room after becoming a patient himself. He was diagnosed with advanced prostate cancer and underwent treatment. However, the disease recurred. In an interview with TODAY, Prof Cheng, who completed radiation therapy in December 2021 for...
  • Research into use of diabetes medication for treatment of metastatic prostate cancer (Metformin)

    08/15/2023 6:54:44 PM PDT · by ConservativeMind · 6 replies
    Patients with localized prostate cancer have a good chance of survival, but mortality rates among those with advanced, metastatic forms of the condition remain high. Until now, the precise mechanism behind the spread of the tumor has not been fully explained. But a research team has succeeded in decoding the underlying cellular signal pathway and has carried out research using a common diabetes medication that could provide a new treatment option. The research team examined prostate cancer cells and identified the key factors in the regulation of tumor cell growth and the way they interact with each other. The protein...
  • Prostate cancer scanning technique waives the need for pre-imaging biopsy in elderly patients

    08/15/2023 10:18:34 AM PDT · by ConservativeMind · 10 replies
    In elderly patients with suspected prostate cancer, a prostate-specific membrane antigen positron emission tomography (PSMA PET) CT scan can diagnose advanced disease and aid in therapy selection without the need for a biopsy. This research demonstrates how imaging with PSMA PET/CT can potentially reduce the number of prostate biopsies in the elderly while providing accurate staging data. 68Ga-PSMA PET/CT has gained acceptance as a highly sensitive and specific imaging modality for evaluating the extent of disease in prostate cancer patients. In general, PSMA PET/CT is indicated when intermediate or high-risk cancer has been found on biopsy. In elderly patients, however,...
  • Next-generation treatment reduces symptoms, preserves sexual function in men with enlarged prostate (Optilume)

    08/14/2023 12:47:30 PM PDT · by ConservativeMind · 10 replies
    Medical Xpress / Wolters Kluwer Health / Journal of Urology ^ | Aug. 10, 2023 | Steven A. Kaplan et al
    Treatment with the recently approved, minimally invasive Optilume BPH device improves urinary symptoms while preserving sexual function in men with benign prostatic hyperplasia (BPH), concludes a randomized trial. The Optilume BPH Catheter System offers a new type of minimally invasive treatment, featuring a dual mechanical and pharmacological mechanism of action. In the Optilume procedure, an uncoated balloon catheter is used to open a passage between the lateral lobes of the prostate (anterior commissurotomy). A second balloon, coated with the antiproliferative drug paclitaxel, is then deployed to further widen the opening. The addition of paclitaxel is thought to prevent continued enlargement...
  • Treatment decisions in new era of individualized therapy for metastatic hormone-sensitive prostate cancer

    06/13/2023 7:16:57 AM PDT · by ConservativeMind · 6 replies
    Oncologists have traditionally prescribed androgen deprivation therapy (ADT) alone for patients with metastatic hormone-sensitive prostate cancer (mHSPC). Now, there are many possible treatment options. Clinical trials have shown that more aggressive up-front treatment with a range of combination therapies improves outcomes. This case study shows how Dana-Farber Cancer Institute oncologists interpreted the evidence from these trials and applied it to an individual patient with mHSPC. The researchers recommend aggressive up-front treatment with triplet therapy (ADT, an androgen-receptor pathway inhibitor, and chemotherapy) for patients who can tolerate chemotherapy, and especially for patients with high-volume disease. For patients with low-volume disease, they...
  • Drug combo ups progression-free survival for metastatic prostate cancer (talazoparib plus enzalutamide)

    06/11/2023 10:14:20 AM PDT · by ConservativeMind · 6 replies
    Medical Xpress / HealthDay / The Lancet ^ | June 8, 2023 | Elana Gotkine / Wassim Abida et al / Neeraj Agarwal et al
    For patients with metastatic castration-resistant prostate cancer (mCRPC), talazoparib plus enzalutamide results in improvement in radiographic progression-free survival (rPFS), according to a study. Neeraj Agarwal, M.D. and colleagues conducted a randomized phase 3 trial of talazoparib plus enzalutamide versus placebo plus enzalutamide as first-line therapy for men with asymptomatic or mildly symptomatic mCRPC receiving ongoing androgen deprivation therapy from 223 hospitals, cancer centers, and medical centers in 26 countries. Patients were prospectively assessed for homologous recombination repair gene alterations in tumor tissue and randomly assigned to once daily talazoparib or placebo (402 and 203 patients, respectively). The researchers found that...