Two-week radiotherapy proven as safe and effective as eight-week course for prostate cancer: 10-year follow-up

Prostate cancer is the most commonly diagnosed cancer in men worldwide, accounting for more than 1.4 million new cases each year. For many patients, radiotherapy is a standard treatment option that offers outcomes comparable to surgery, particularly for localized disease.

As an outpatient procedure, it allows men to maintain much of their daily routine during treatment. However, traditional radiotherapy schedules typically span several weeks, which can be burdensome for patients and put pressure on health care structures and radiotherapy capacity.

A major clinical trial (HYPO-RT-PC) has shown that a significantly shorter course of radiotherapy for localized prostate cancer is just as safe and effective as the traditional eight-week schedule—even 10 years after treatment.

The study found that delivering precision radiotherapy over just two and a half weeks is equally successful in beating prostate cancer as the standard eight-week approach. A decade after treatment, both options produced similar disease control rates and survival.

This large Phase III clinical trial enrolled 1,200 men with intermediate- to high-risk localized prostate cancer. Participants were randomly assigned to receive either:

—Short-course radiotherapy: 42.7 Gray (Gy) delivered in seven sessions over 2.5 weeks

Researchers assessed survival, cancer recurrence, and treatment-related side effects, including urinary and bowel symptoms.

Key outcomes after 10 years: —Failure-free survival (no return of cancer or need for additional treatment): 72% in the short-course group vs. 65% in the standard group

—Side effects: Urinary and bowel symptoms were similar in both groups, and most were mild to moderate.

"These findings confirm that the shorter course does not increase long-term side effects and provides equally durable cancer control," added Camilla Thellenberg-Karlsson, MD, Ph.D.

Dr Makis has several prostate treatment success stories.

He is on X .... his substack is behind a paywall but I can copy and paste the protocols...

https://x.com/MakisMD

Here’s one ...

PROTOCOL:
We started the following protocol:

Ivermectin 1mg/kg/day

Fenbendazole 444mg/day

Melatonin 120mg/day

IP6

Artemisia

Blackseed oil

Berberine

My Take…

“approaching 4 months on Ivermectin plus the other products”

“the oncologist report is that there is shrinkage in all areas (prostate, bladder wall and lymph nodes. He is not in remission as yet”.

The answer to the question is: continue until remission. The Protocols I use are designed for 3 months with a reassessment to make sure tumors are responding.

Here’s another...

STORY:
60s year old Prostate Cancer patient, new diagnosis, Gleason 7 (3+4 and 4+3) with bilateral disease.

Famous US Cancer Centre:

“Overall, I think you will eventually come to need treatment of your prostate and because you appear to have bilateral disease, whole gland treatment is likely the best cancer strategy. Whether undergoing treatment now, or observing for a bit longer is the best route depends on your goals.”

“We can consider radical prostatectomy…I’m less enthusiastic about radiation treatment as you are very young and likely to experience the secondary effects of radiation on your normal tissue as you age.”

Pretty standard stuff from a large US Cancer Centre that is stuck in the “Big Pharma guidelines” era.

IVERMECTIN/FENBENDAZOLE:
Patient did about a month of Fenbendazole 222mg Joe Tippens Protocol, then I got involved.

We started a high dose Ivermectin/Fenbendazole Protocol
My Take:
PSA went: 4.4 to 3.6 to 2.46 (lowest PSA level in 2 years)

44% drop in PSA in about one month!

Transient visual symptoms affect some patients at Ivermectin doses above 60mg. They tend to go away with time.

Why the high dose Ivermectin/Fenbendazole regimen?

young patient

“A Gleason Score of 4+3 represents a moderately aggressive form of prostate cancer.”

“bilateral disease at the prostate apex plus an additional region with cancer at the base.”

Liver/Kidney functions were normal, with slight elevation in Bilirubin.
Patient replied...

My current dosage of Ivermectin once per day is 2mg/kg/day (162mg) 7 days a week and
Fenbendazole is 888mg/day 6 days a week, split into 2 doses with food. I am also taking
the Bioactive Compounds as well.
So main question, do I need to reduce Ivermectin or Fenbendazole so I don’t have any
liver or kidney issues?

I find that Ivermectin and Fenbendazole are well tolerated and it’s very rare to see any issues on bloodwork.

I’ve caught some Oncologists lying to their patients about the possible risks of Ivermectin or Fenbendazole on liver function. They insist that Ivermectin and Fenbendazole are “dangerous”.

In reality, only 2-3% of patients see issues on their blood work and these patients usually have either a primary liver malignancy or extensive liver metastases.

The goal is to clear these malignant prostate lesions without need for invasive treatment options like radical prostatectomy.

~~~~~

Hope this helps.

I'm 20 years out after Cyberknife treatment. I don't understand why this protocol (proton) is still around. Multiple weeks of blasting the entire area vs 4 days of precision treatment (Cyberknife). One of my take aways in researching what treatment to use was that every doctor/facility has a very large investment in both money and education in one of several choices. Now not every choice is correct for every situation but in general surgeons want to cut, radiation clinics want to use the machines they have, brachytherapy experts want to do their thing. My doctor was a brachytherapy expert. World class guy. The hospital had just purchased the Cyberknife system. He was not eager to use it but six months later he told me the ones that did had far fewer side effects than his other patients.

At the time (20 yrs ago) proton had a poor success rate, was totally disruptive to your life for weeks, and had a lot of side effects. The described protocol sounds like an improvement but there are other choices.

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