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Recently, researchers have discovered an increasing correlation between some liver cancers and non-viral chronic liver disease (CLD). One liver cancer, hepatocellular carcinoma (HCC), is associated with CLD in about 15%–25% of cases. In order to investigate how healthy liver tissue differs from that of HCC patients with CLD, scientists analyzed which metabolites were present in CLD and normal tissue to identify metabolic pathways that may be dysregulated. By investigating differences in gene expression and metabolites, the investigators were able to identify possible disease-causing pathways and potential therapeutic targets for HCC prevention. "The molecular mechanisms underlying the development of HCC from...

Investigators have validated a test that can accurately predict which patients with prostate cancer are at higher risk of developing long-lasting urinary side effects after receiving radiation therapy. The test, called PROSTOX, is the first of its kind to use microRNAs to predict toxicity from cancer therapy. It could help prevent the burden of long-term complications by identifying patients most at risk before treatment even begins. The team validated PROSTOX's ability to predict long-term urinary side effects. "What makes PROSTOX different is that it looks at a patient's unique genetics to estimate their personal risk of developing side effects from...

Sustained research funding is essential to progressI don't usually talk about my cancer diagnosis. But as a physician-scientist who survived leukemia at 18 years old and now cares for people facing their own cancer diagnoses, I feel compelled to share my story -- because it speaks directly to what's at stake in medicine today. The clinical trial that saved my life wouldn't have existed without robust investment in biomedical research. And as debates over federal research funding continue, I think about whether future patients will have access to the same life-saving opportunities I did. It was the summer of 2007....

Fasting has shown its potential to reduce colorectal cancer risk by triggering cellular changes that may slow tumor growth, with a study demonstrating a 20% improvement in overall survival. However, lifestyle changes alone aren't enough for prevention. Fasting has been shown to activate autophagy, the body's natural process of cleaning out damaged cells and regenerating healthy ones. According to a review, autophagy plays a key role in preventing cancer development by maintaining cellular health and reducing oxidative stress. By clearing away cells that might otherwise turn cancerous, fasting may help the body maintain a more stable and resilient internal environment....

Now this is mind blowing Joe Rogan “Kids Wish Network: - They raised $127 million - They paid to solicitors $109 million - They spent percentage on direct cash - Aid to the actual kids is ONLY 2.5% - Look at the Cancer Fund of America. LESS THAN 1% went to the actual thing”

Researchers presented promising results from an early-stage clinical trial investigating a unique coffee-based approach to ovarian cancer maintenance therapy. The study examined ArtemiCafe Decaf, a commercially available decaffeinated coffee product containing a controlled dose of Artemisia annua, a plant that has been used medicinally for centuries and is known for its antimalarial properties. Recent laboratory research has shown the plant may also have anti-cancer properties. Preliminary findings of the phase 1 trial show that ArtemiCafe Decaf is safe and well tolerated by patients at a dose of four cups daily. Additional patient follow-up is needed to determine its efficacy in...

The transformation of healthy cells into invasive colorectal tumors is an extraordinarily complex process involving numerous molecular mechanisms, according to cancer biologists who have discovered that low levels of a single enzyme strongly influence the pathway to malignancy. The team highlighted an enzyme named GPT1, which stands for glutamic-pyruvic transaminase 1. Colorectal cancer is characterized by decreased amounts of GPT1, a metabolic enzyme with apparent functions in cancer progression. Li Xiong confirmed decreased GPT1 in CRC patients and demonstrated in a series of experiments that low expression of GPT1 was associated with worse CRC prognoses. "We analyzed transcriptomic profile changes...

An international team has found genomic testing and targeted therapies for patients with advanced cancer could improve survival rates by up to 40%. The team conducted a review of 37 trials. It found next-generation sequencing could help guide matched targeted therapies (MTT) for people with relapsed or metastatic cancer, delaying the progression of their cancer compared to standard treatments. "Next-generation sequencing (NGS) of cancer identifies specific mutations in the DNA of a person's cancer cells," said Dr. Shrestha. "These mutations can give clinicians clues about why the cancer is growing and which treatments might work best. "Targeted therapies designed to...

Call it a new type of precision medicine. A researcher says one day oncologists may be able to write personalized exercise "prescriptions" for cancer patients that suppress tumor growth. Jay Taylor helped develop a mathematical model that attempts to quantify the relationship between exercise, immune function and cancer. The paper looked at models of mice running on wheels to show that increases in exercise intensity and duration decrease the proliferation of malignant cells. According to the paper, the team worked on a mathematical model to describe the transition of natural killer cells from inactive to active states due to exercise-induced...

Ten maternity nurses working on the same floor at a Massachusetts hospital have developed aggressive brain tumors. Staff at Newton-Wellesley Hospital have developed various forms of brain cancer over the past few years. As many as 10 nurses on the same maternity ward at Newton-Wellesley Hospital have been diagnosed with brain cancer. One nurse, who asked to remain anonymous, told WBZ-TV: “It’s getting to the point where the number just increases, and you start saying am I crazy thinking this. This can’t just be a coincidence.” “We want reassurance because this has not been a reassuring past few months for...

A new peer-reviewed study links the mRNA COVID-19 vaccines to long-term changes in genetic structures that can provoke an inflammatory response, and lead to the onset of cancer and autoimmune disorders. The study by 19 German scientists was published last week in Molecular Systems Biology. The researchers said their findings may account for “post vaccination inflammatory diseases which occur in a small number of vaccinated individuals.”

A new study published in the journal Immunity reveals a mechanism that allows triple negative breast cancer (TNBC) to develop resistance to therapy. Researchers showed that lipid accumulation in tumor cells and nearby immune cells promotes immune suppression, but disrupting lipid formulation reverses treatment resistance and the immunosuppressive microenvironment. Standard-of-care treatment for TNBC includes chemotherapy and immunotherapy. However, some initially responsive tumors still develop recurrences. Researchers studied mouse models and found that TNBC cells that survived treatment accumulated lipid droplets containing Omega-6 fatty acids. Single-cell RNA sequencing revealed that neutrophils, a type of white blood cell, near the tumor cells...

Opinion Cancer is one of the leading causes of death worldwide, with millions of new cases reported each year. In 2022 alone, approximately 20 million new cancer cases were diagnosed globally, and 9.7 million lives were lost to the disease. In India, the numbers are equally alarming, with around 100 out of every one lakh people diagnosed with cancer. According to the Indian Council of Medical Research (ICMR), more than 14 lakh cancer cases were estimated in 2023. [1 lakh = 0.1 million] Despite advancements in early detection and treatment, many myths surrounding cancer testing prevent people from undergoing timely...

A research team is testing a new combination drug therapy that could both treat and prevent melanoma metastasis to the brain. Holmen first examined what causes melanoma cells to spread to the brain and identified focal adhesion kinase (FAK) as a potential target for new therapies. FAK is an enzyme that regulates cell growth, and, they found, is a major contributor to melanoma metastasis. "The window of time to treat a patient with brain metastasis is shortened because the average survival from time of diagnosis of brain metastasis is only about a year—even while using these other therapies." Holmen and...

Dr. Patrick Soon-Shiong is a surgeon who made billions inventing cancer drugs. He says that Covid, and the vaccines that didn’t stop it, are likely causing a global epidemic of terrifyingly aggressive cancers.Chapters 5 chapters in this episode1. Why Are Cancer Rates Rising in Young People? 2. What Is Causing This Cancer Epidemic? 3. Is There a Connection Between Covid and Cancer? 4. How Big Pharma Tried to Undermine Dr. Soon-Shiong 5. Dr. Soon-Shiong’s Analysis of RFK Jr.

There’s a terrifying trend happening right now—and most of the so-called “experts” who have let us down in every way imaginable are pretending not to see it. So, what’s happening? Well, cancer is exploding. And not just in adults. Children—actually very young children—are now being diagnosed with these extremely aggressive, fast-moving cancers at a rate that’s impossible to ignore. But instead of asking hard questions, the same crowd of “experts” that once shouted down anyone who dared question the COVID vaccine has gone radio silent. Suddenly, they’ve lost all curiosity. Suddenly, they don’t want to “follow the science.” ... The...

There were new fears for King Charles’ health Thursday, after the king was briefly hospitalized after suffering “temporary side effects” following scheduled treatment for his cancer. A number of engagements on Thursday were cancelled, and the palace said that they were cancelling a raft of commitments scheduled for Friday “as a precautionary measure.” Sources sought to play down the severity of the incident and said that the king was working at his desk at his London home Thursday evening, with one saying, “This is simply the most minor bump in a road that’s very much heading in the right direction.”...

In a frank discussion about the ongoing conflict in Ukraine, President Volodymyr Zelensky expressed his belief that Russian President Vladimir Putin's time is running out, stating, "He will die soon, and that's a fact, and it will come to an end." Zelensky also said he believes Putin is terrified of losing power within Russia during a roundtable conversation with journalists, including the BBC's Jeremy Bowen. Meanwhile, NATO Secretary-General Mark Rutte issued a stern warning to Russia, emphasizing that the alliance would unwaveringly support Poland or any other member in the event of an attack. During a visit to the country,...

Dr. Patrick Soon-Shiong is a surgeon who made billions inventing cancer drugs. (He is also the current owner of the Los Angeles Times!) Shiong lends his perspective on the rise in cancer rates, especially among young people, as well as insights into the shortcomings of established treatment protocols that have remained virtually unchanged for decades. One of Tucker’s better conversations! Aired live earlier today.

Researchers have found statin use significantly reduces the risk of hepatocellular carcinoma (HCC) and hepatic decompensation among patients with chronic liver disease (CLD). Statins, particularly lipophilic statins like atorvastatin and simvastatin, were associated with a substantial decrease in the likelihood of liver cancer and complications. Longer duration of statin use further increases this protective effect. Researchers conducted a historical cohort analysis of data from the Research Patient Data Registry, clinical data from hospitals within the Mass General Brigham health care system, covering 2000-2023. Participants included 16,501 adult patients aged 40 or older diagnosed with CLD and a baseline Fibrosis-4 (FIB-4)...