Diabetes drug shows potential to slow prostate cancer cell growth (Actos)

Medical Xpress / Medical University of Vienna / Molecular Cancer ^ | May 6, 2025 | Emine Atas et al

[ConservativeMind]

An international team of scientists has identified similarities in the mechanisms of diabetes and cancer: as the researchers show, the protein PPARγ, which is central to the regulation of metabolic processes, can also influence the growth of prostate cancer cells. PPARγ is already known to be a target of certain drugs used to treat type 2 diabetes.

The results of the study indicate that such drugs could also represent a promising approach for the treatment of prostate cancer.

PPARγ has been known in diabetes research for quite some time, as it has an influence on insulin sensitivity. For more than 20 years, the protein has been the target of certain medications, including so-called thiazolidinediones such as pioglitazone, which are used to treat type 2 diabetes.

In the search for new, targeted therapeutic approaches for tumors, cancer research has also been looking at this for several years. PPARγ (peroxisome proliferator-activated receptor gamma) is a transcription factor that plays an important role in the regulation of metabolic processes, inflammatory reactions and cell growth as a gene activator.

As the research team has now shown, it is also associated with the growth of prostate cancer.

"It was shown that the diabetes drug pioglitazone influences the activity of PPARγ and thus inhibits the growth behavior and metabolism of tumor cells. Furthermore, initial results revealed that prostate cancer patients with diabetes who were treated with PPARγ agonists had not relapsed at the time of data collection," explains Emine Atas.

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TOPICS: Health/Medicine
KEYWORDS: actos; cancer; prostate; prostatecancer; treatment

[ConservativeMind]

Pioglitazone (generic Actos) is available today and Walmart appears go have it for $3 for a 30 day supply.

[ConservativeMind]

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