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Patients with advanced lung cancer who received immunochemotherapy before 15:00 (3 p.m.) had a more delayed disease progression than patients receiving treatment later in the day. The findings, published as part of a randomized phase 3 trial of 210 participants, suggest that scheduling therapy early in the day may offer a simple, cost-neutral way to enhance standard care. Circadian rhythms, the internal 24-hour clock, are known to affect immune cell behavior and responses to treatment. Previous retrospective studies across cancers, such as kidney cancer and malignant melanoma, have hinted that administering immune checkpoint inhibitors earlier in the day might be...

People with compromised liver function may be able to reduce their risk of liver cancer or slow its progression with a simple dietary change: eating less protein. A study has found that low-protein diets slowed liver tumor growth and cancer death in mice, uncovering a mechanism by which a liver's impaired waste-handling machinery can inadvertently fuel cancer. When people consume protein, the nitrogen can be converted into ammonia, a substance that's toxic to the body and brain. A healthy liver typically processes this ammonia into harmless urea, which is excreted via urine. To test whether impaired ammonia processing drives cancer...

A team of researchers have identified a fundamental mechanism that links the 24-hour circadian cycle to the precise repair of DNA breaks. This study, focused on the circadian protein Cryptochrome1 (CRY1), suggests that the time of day when radiotherapy is administered can significantly influence the effectiveness of treatment for certain types of cancer. It is relatively common for cancer cells to be unable to repair their DNA efficiently. Treatments, such as radiotherapy, exploit this by generating DNA breaks that tumor cells are unable to repair. This study shows DNA break repair in human cells exhibits a circadian oscillation. In a...

In December, Marvin Morales‑Ortez walked out of a Fairfax County, Va., jail a free man. He shouldn’t have. Morales‑Ortez was in the country illegally; he was in jail on serious charges, including for a violent assault and a firearm offense. Those charges were dropped. He was released. Within 24 hours, police say, he murdered a man. This was not bad luck. It was policy. Fairfax’s Commonwealth’s Attorney Steve Descano has openly promised to limit or avoid “immigration consequences” when charging criminals. In other words, his office will treat illegal immigrants more leniently than US citizens. Descano’s policy directs his prosecutors...

Researchers have identified a metabolically sensitive cell subtype in the eye's drainage system which shows early signs of dysfunction in a genetic mouse model of glaucoma. The study provides a potential therapeutic strategy for preventing or slowing the development of glaucoma. Glaucoma, a group of eye diseases that damage the optic nerve. The main risk factors is high intraocular pressure, which results from dysfunction in the trabecular meshwork—a porous tissue that helps maintain normal eye pressure. Tolman used single-cell RNA sequencing to profile nearly 18,000 cells. They identified six major cell types, with further analysis revealing three subtypes of trabecular...

Nick Reiner, who has been charged with the murder of his parents, Rob Reiner and Michele Singer Reiner, was placed into a yearlong mental health conservatorship in 2020, according to two people with knowledge of the legal arrangement.

Does this look legit? Alzheimer's Reversal??? +++++++++ WHAT'S WRONG: Your family member has Alzheimer's disease. This is a brain sickness that makes people forget things and get confused. It happens because parts of the brain stop working right. THE GOOD NEWS: +++++++++ Scientists just found new ways to help fix the brain. We now have a plan that uses three different medicines that work together to help the brain get better. HOW THE TREATMENT WORKS: +++++++++ Think of the brain like a house with three problems: PROBLEM 1: The lights are dim The brain cells don't have enough energy Medicine...

Scientists have reversed Alzheimer’s disease in mice, potentially showing a pathway to treat the illness among humans, according to a Dec. 22 peer-reviewed study published in the Cell Reports Medicine journal.Alzheimer’s is traditionally considered irreversible. In the study, researchers treated two groups of mice with P7C3-A20, a pharmacologic agent. One group carried human mutations related to amyloid processing, while the other carried a tau protein mutation. Both amyloid and tau pathologies are two major early events of Alzheimer’s. Researchers say that as mice develop brain pathologies resembling Alzheimer’s, they are ideal subjects to test how P7C3-A20 affects Alzheimer’s in humans....

[H/T ExTexasRedhead]The Nobel prize winning miracle drug Ivermectin works as an antiviral, anticancer, is part of a Lyme Disease cure protocol, and even reverses dementia, all while having a safety profile that is far superior to aspirin or any “vaccine” for that matter.Cancer surgeon Dr. Kathleen Ruddy had the following to say about Ivermectin:Cancer Surgeon: “Ivermectin Is SAFER Than a Sugar Pill” 👁️“You’d have to take a lot to make yourself sick.”Dr. Kathleen Ruddy has also observed multiple late-stage cancer patients make dramatic recoveries after taking ivermectin.Ivermectin is also:• A Nobel Prize-winning discovery (2015)• Recognized, 2nd to penicillin, for having...

A single course of low-dose radiation therapy may provide a safe and effective alternative treatment option for people with painful knee osteoarthritis according to a new randomized, placebo-controlled clinical trial. The study showed patients with mild to moderate knee osteoarthritis reported significant reductions in pain and improved physical function in the four months after receiving the low dose of radiation, which was just a small fraction of what's used to treat cancer. The study included a control group with simulated treatment. Low-dose radiation is regularly used for joint pain in European countries such as Germany and Spain. The doses were...

A study has found that a surgical technique developed to protect vision in patients with uveal melanoma, a rare cancer that arises inside the eye, may also lower the risk of the disease spreading and improve survival.. The study followed 37 patients who were treated for uveal melanoma. Most received targeted radiation, known as plaque brachytherapy, combined with a specialized procedure that replaces the eye's gel-like interior with silicone oil, a technique designed to shield healthy parts of the eye from radiation damage while allowing the tumor to receive the full cancer-killing dose. Over a median follow-up of more than...

The technique, known as IORT, has numerous benefits, surgeons say, but it generates less money for hospitals and radiation oncologists.It’s not uncommon for breast cancer patients in the rural South to travel hundreds of miles to reach the medical practice run by Dr. Phillip Ley, a cancer surgeon in Jackson, Mississippi. For those who are good candidates, Ley recommends a therapy that delivers a single, targeted radiation dose to a patient’s breast tissue immediately after surgery to remove a tumor. Known as intraoperative radiation therapy, or IORT, it costs patients less in both time and money than traditional radiation treatments,...

Colorectal cancer remains a leading cause of cancer death, with incidence rising among older adults. One of the most pressing clinical questions has been whether elderly patients should receive oxaliplatin, a standard component of adjuvant chemotherapy that is known to cause serious side effects. To address this, Dr. Jun Woo Bong conducted a large-scale population study. The team examined health records from more than 8,500 patients with stage II or III colorectal cancer who underwent surgery followed by chemotherapy between 2014 and 2016. Patients were divided into two groups: those treated with oxaliplatin-based combinations, and those given standard chemotherapy alone....

A team of researchers explored the cellular and molecular interactions revealing how lymph nodes play a crucial role in the fight against chronic infection and cancer. The research showed that lymph nodes provide the right environment for stem-like T cells, an important type of immune cell, to survive, multiply and produce killer cells that can fight cancer or viruses. In other immune organs, such as the spleen, these cells don't develop or proliferate as effectively, making lymph nodes essential for a strong immune response and successful immunotherapy. Professor Axel Kallies said the findings have important implications for cancer therapy. "Lymph...

Listen to this story IN THE POPULAR imagination, cancer starts with a mutation in the DNA of a normal cell. That mutation allows the cell to multiply uncontrollably, circumventing the body’s usual quality-control checks. Eventually, a tumour forms and breakaway cells spread to other parts of the body. But in the past few years scientists have been finding something surprising—so-called cancer-driver mutations are also common in healthy tissue. Such mutations appear in around a quarter of healthy skin cells. When a person is middle aged more than half the surface of the oesophagus and nearly 10% of the lining of...

Researchers have identified a new way to treat certain blood cancers using existing drugs, by turning a once-dismissed part of our DNA into a therapeutic target. The study focused on myelodysplastic syndrome (MDS) and chronic lymphocytic leukemia (CLL). These cancers often have mutations in two key genes, ASXL1 and EZH2, which normally control the activity of other genes by switching them on or off. When these genes are damaged, cells lose control of their ability to create new cells, resulting in abnormal cell growth. Nearly half of human DNA is made up of repetitive sequences called transposable elements (TEs), once...

Intense light therapy after surgery can increase a critical protein that protects heart tissue while lowering levels of troponin, a protein indicating heart damage that's linked to higher mortality in patients undergoing non-cardiac surgery, according to a study. The results add to a growing body of evidence showing that intense light has a healing effect on the heart and blood vessels, a finding that could help reduce the number of cardiac events that happen after surgery. Myocardial Injuries in Noncardiac Surgeries (MINS) occur in about 20% of patients and significantly increase one-year mortality rates. "The risk of myocardial injury goes...

One of the cruellest and most devastating diseases – Huntington's – has been successfully treated for the first time, say doctors. The disease runs through families, relentlessly kills brain cells and resembles a combination of dementia, Parkinson's and motor neurone disease. An emotional research team became tearful as they described how data shows the disease was slowed by 75% in patients. It means the decline you would normally expect in one year would take four years after treatment, giving patients decades of "good quality life", Prof Sarah Tabrizi told BBC News. The new treatment is a type of gene therapy...

In 2023, according to the US Centers for Disease Control, 613,349 Americans died of cancer. That number is projected to increase to over 618,000 this year. As a result, medical research has been focused on the development of cancer treatment protocols for decades for all types of cancer.The National Cancer Institute’s Cancer Trials Support Unit (CTSU) and the National Institute of Health’s ClinicalTrials.gov website list hundreds of active protocols, with 457 NCI-supported protocols noted in clinical trial databases for various cancer types and stages.For example, there are approximately a dozen known treatment protocols for Stage 4 prostate cancer that focus...

Forskolin, a natural compound derived from a plant, could significantly improve treatment outcomes for an aggressive form of leukemia, known as KMT2A-rearranged Acute Myeloid Leukemia (KMT2A-r AML), according to a new study. The study shows that not only does forskolin directly stop the growth of leukemia cells, but it also enhances the effectiveness of chemotherapy drugs. Researchers from Surrey found that forskolin activates Protein Phosphatase 2A (PP2A) and stops the expression of several cancer-promoting genes (MYC, HOXA9 and HOXA10). The research also shows a significant and unexpected finding, as forskolin was found to substantially increase the sensitivity of KMT2A-r AML...