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Cervical cancer is one of the most common gynecologic cancers worldwide and continues to be a leading cause of cancer-related death in women. While early detection through screening has improved outcomes, treatment options for advanced or recurrent disease remain limited. The five-year survival rate for late-stage cervical cancer is still less than 20%, underscoring the urgent need for better therapies. The disease is most often linked to high-risk human papillomavirus (HPV) infection, but other factors also contribute to tumor progression—such as changes in the immune system, abnormal cell survival signals, and increased blood vessel formation that supports tumor growth. Current...

Radiation therapy can promote the epidermal growth factor receptor (EGFR) ligand amphiregulin, which increases growth of existing metastases in patients with advanced solid tumors, according to a study. András Piffkó, M.D. and colleagues explored the potentially deleterious effect of radiation in promoting metastasis in patients with advanced solid tumors who received stereotactic body radiotherapy to multiple metastatic sites. Gene expression was examined in 22 matched preradiotherapy and postradiotherapy biopsies for irradiated metastases. The researchers found that the EGFR ligand amphiregulin was induced by radiotherapy in tumor cells; amphiregulin reprograms EGFR-expressing myeloid cells toward an immunosuppressive phenotype and can reduce phagocytosis....

"... stevia leaf extract fermented with L. plantarum SN13T, which contains CAME, may serve as a promising candidate for pancreatic cancer treatment." Stevia (Stevia rebaudiana Bertoni) is a perennial herb widely utilized in the food and pharmaceutical industries, valued not only for its intense natural sweetness but also for its potential health-promoting properties. In addition to steviol glycosides, stevia leaves are rich in flavonoids and phenolic compounds, which exhibit various biological activities, including antioxidant, anti-inflammatory, antihypertensive, and anticancer effects. While purified steviol glycosides and their derivatives (e.g., stevioside, isosteviol) have demonstrated cytotoxic and antiproliferative activities against several cancer cell lines,...

New research finds that for people diagnosed with nonmetastatic low-risk prostate cancer later in life, and treated according to NCCN Clinical Practice Guidelines in Oncology, 90% were likely to survive their cancer for their remaining life-expectancy. Of those with nonmetastatic higher-risk cancer and a longer life expectancy, that likelihood was still greater than 65%. The researchers studied 62,839 people diagnosed with non-metastatic prostate cancer in Sweden between the years 2000-2020. All were placed within a defined risk category, had a life expectancy of more than three years, and were treated according to evidence-based, expert consensus-driven recommendations. Those with low- and...

Ovarian cancer cells dividing. (Credit: ecancer) In A Nutshell High-throughput drug screening identified rigosertib as highly selective for ovarian cancer cells. Alone, rigosertib shuts down one survival pathway but triggers compensatory activation of another. Combining rigosertib with PI3K/mTOR inhibitors prevents this resistance and shrinks tumors in mice. Human trials are needed to confirm safety and effectiveness before clinical use. ================================================================== NEW YORK — Scientists have identified a potentially game-changing treatment approach for ovarian cancer, one of the deadliest forms of the disease that kills roughly 12,740 American women each year. The breakthrough involves pairing an existing drug called rigosertib with...

Fisherman holding a pair of sea cucumbers. (Photo by The Pirates on Shutterstock) Scientists Discover Sea Cucumbers Contain Powerful Compound That Fights Aggressive Tumors In a nutshell * Scientists found that a compound from sea cucumbers can block Sulf-2, an enzyme that helps cancer cells spread throughout the body * Smaller fragments of the sea cucumber extract work just as well as the full compound but cause fewer side effects * The compound targets cancer cells specifically without broadly attacking healthy cells like traditional chemotherapy ========================================================================== UNIVERSITY, Miss. — Scientists at the University of Mississippi have discovered that a slimy...

Hepatitis B virus (HBV) infection is known to be associated with the risk of hepatocellular carcinoma (HCC), but how and why they are connected remains unknown. Researchers from Mass General Brigham discovered that HBV does not cause liver inflammation or cancer on its own, but worsens liver inflammation and may make patients more susceptible to early cancer development caused by environmental carcinogens. Limiting carcinogen exposure or reducing inflammation could mitigate this risk. "Our research sheds light on the intricate interplay between HBV infection and carcinogen exposure to generate immune dysregulation in the liver that leads to cancer development," said corresponding...

A study led by Dana-Farber Cancer Institute researchers found that combining chemotherapy and immunotherapy before surgery for patients with aggressive stage III non-small cell lung cancer that is considered difficult or impossible to surgically remove can help shrink tumors and make surgery possible. The multicenter observational study was conducted in collaboration with Memorial Sloan Kettering Cancer Center and IRCCS Regina Elena National Cancer Institute in Rome, Italy. It analyzed data from 112 patients who were treated at cancer centers across the U.S. and Italy with chemoimmunotherapy—a combination of chemotherapy and an immune checkpoint inhibitor blocking PD-1 or PD-L1. After treatment,...

From myocarditis to turbo cancer, emerging research offers hope for the millions injured by mRNA shots. Millions of people injured by mRNA injections have been completely abandoned by our public health agencies. In the absence of meaningful support, it is critically important to identify and advance safe, evidence-based strategies to aid recovery. At the McCullough Foundation, ongoing research has highlighted the following key interventions: Vitamin D Mounting evidence supports vitamin D as a critical intervention for vaccine injury: Myocarditis Protection: 73.3% of mRNA vaccine-induced myocarditis cases were vitamin D deficient, and low levels correlated with significantly worse inflammation, higher troponin...

In a study conducted at São Paulo State University involving 80 women over the age of 45, low-dose vitamin D supplementation nearly doubled the rate of treatment response. A study conducted at the Botucatu School of Medicine at São Paulo State University (FMB-UNESP) in Brazil found that low-dose vitamin D supplementation can improve the effectiveness of chemotherapy in women with breast cancer. The findings suggest that vitamin D may serve as an alternative to other drugs designed to boost chemotherapy response, especially those that are difficult to access. The research, supported by FAPESP, included 80 women over the age of...

Researchers have harnessed a deadly fungus (Aspergillus flavus) to create a powerful cancer-fighting agent.The development is particularly notable as this toxic crop fungus has a grim historical connection. The fungus was linked to mysterious deaths among archeological teams excavating ancient tombs.For instance, in 1922, the opening of King Tutankhamun's tomb was reportedly followed by unexplained deaths, fueling rumors of a "pharaoh's curse."But it was later hypothesized that a dormant fungus might have been responsible.Fast forward to the 1970s. A similar tragedy unfolded in Poland, where 10 scientists died within weeks of entering the tomb of Casimir IV.The culprit was identified...

First-line treatment with the triplet combination of encorafenib, cetuximab and mFOLFOX6 significantly improved survival compared to the standard of care in patients with BRAF V600E-mutated metastatic colorectal cancer, according to data from the Phase III BREAKWATER trial. The findings demonstrated significantly longer progression-free survival (PFS) and overall survival (OS) compared to standard chemotherapy-based regimens. The median PFS was 12.8 months with the triplet combination compared to 7.1 months in the standard-of-care group, and the median OS was 30.3 months compared with 15.1 months, respectively. "The latest data from the BREAKWATER trial further confirms that targeting the BRAF V600E mutation up...

Strawberry tree extracts helped treat ulcerative colitis in rats. (HJBC/Shutterstock) In a nutshell A traditional Mediterranean plant, the strawberry tree (Arbutus unedo), showed strong protective effects against ulcerative colitis in rats, performing nearly as well as a common prescription drug. The extract worked by reducing inflammation, preventing tissue damage, and restoring antioxidant enzyme levels, suggesting multiple mechanisms of action. While promising, these findings are from animal studies, and more research is needed before the extract can be considered a safe or effective treatment for humans. ======================================================================== JENDOUBA, Tunisia — A humble fruit from the Mediterranean region might hold the key...

In a study, researchers explore a surprising phenomenon in which high doses of radiation cause growth in existing metastatic tumors that weren't directly treated with radiation. Scientists had previously observed that radiation can cause distant tumors to shrink after radiation, known as the "abscopal effect." The researchers dubbed the opposite response the "badscopal effect." They believe this unexpected response happens because high-dose radiation increases the production of a protein called amphiregulin by tumor cells that are directly treated with radiation. High amounts of amphiregulin weaken the immune system's ability to fight cancer and make cancer cells better at protecting themselves....

An interdisciplinary research team has demonstrated a durable and lasting response to a novel treatment—combined locoregional therapy and immunotherapy (LRT-IO)—for advanced liver cancer patients. Advanced liver cancer is often considered incurable, but it can sometimes be converted to a treatable stage through a combination of therapies, potentially leading to curative surgery. This innovative strategy consists of three treatments: stereotactic beam radiotherapy (SBRT) with optional transarterial chemoembolization (TACE), followed by immunotherapy (IO). In previous studies, the team found that the cancer completely disappeared in 42% of patients after treatment, as evidenced by MRI or CT scans—even without curative surgery. The research...

Presented at ESTRO 2025 in Vienna, Austria, a 10-year study involving over 4,000 UK patients confirms that a one-week course of post-surgery radiotherapy is just as safe and effective as the traditional three-week regimen for early-stage breast cancer patients. These long-term results from the FAST-Forward trial could further reduce the burden on breast cancer patients worldwide, and expand access to life-saving radiotherapy. The phase III randomized trial followed up patients for ten years and showed that a shorter, five-day radiotherapy schedule provides a similar level of cancer control as the standard 3-week treatment, without additional long-term side effects. This builds...

[FULL TRANSCRIPT BELOW] “I was as astonished as anyone might be that ivermectin has potential as an anti-cancer agent,” says cancer surgeon Dr. Kathleen Ruddy. She’s observed multiple cases where patients with severe, late stage cancer started to make a turn for the better after taking ivermectin. One patient with stage four prostate cancer tried all the traditional protocols like chemotherapy and radiation before being told that there was nothing left that his doctors could do. He started taking ivermectin as a last resort. In a few short months, he had made a stunning recovery. After observing several cases like...

Exercise can counter the detrimental effects of cancer treatment, such as heart and nerve damage and brain fog, suggests an overarching review. Exercise also seems to boost psychological well-being and overall quality of life, say the researchers. The researchers carried out an umbrella review of the existing pooled data analyses of randomized controlled trial results, published between 2012 and July 2024. The review included 485 associations from 80 articles, all evaluated as being of moderate to high quality. Among these associations, the types of exercise of any length, intensity, and duration included mind-body (138, 28.5%), such as Qigong, tai chi,...

Scientists have discovered a promising new therapy for resistant high blood pressure, leading to a 15-point drop in systolic levels. Researchers at the University of California, San Diego School of Medicine have identified a potential new treatment for individuals with uncontrolled or treatment-resistant hypertension, a condition commonly referred to as high blood pressure. The investigational drug, lorundrostat, showed encouraging results in a recent clinical trial. Published in the New England Journal of Medicine, the study found that participants who received lorundrostat experienced an average 15-point reduction in systolic blood pressure, the upper number in a blood pressure reading, compared to...

An international team of scientists has identified similarities in the mechanisms of diabetes and cancer: as the researchers show, the protein PPARγ, which is central to the regulation of metabolic processes, can also influence the growth of prostate cancer cells. PPARγ is already known to be a target of certain drugs used to treat type 2 diabetes. The results of the study indicate that such drugs could also represent a promising approach for the treatment of prostate cancer. PPARγ has been known in diabetes research for quite some time, as it has an influence on insulin sensitivity. For more than...