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WASHINGTON (AP) — President Joe Biden, struggling to convince Americans that he's improved their lives as he runs for reelection, hailed his administration's Tuesday announcement that several drugs would be targeted for Medicare's first-ever price negotiations. The drugs include the blood thinner Eliquis, diabetes treatment Jardiance and eight other medications. The negotiation process was authorized under the Inflation Reduction Act, which Biden signed last year, capping decades of debate over whether the federal government should be allowed to haggle with pharmaceutical companies. Any lower prices won't take effect for three years, and the path forward could be further complicated by...

A recent phase three study conducted by Eli Lilly examined the safety and efficacy of the study drug donanemab in participants with early Alzheimer's disease (AD). The pharmaceutical company Eli Lilly announced in a press release on May 3, 2023, that a clinical trial of the experimental Alzheimer's drug, donanemab, showed it could significantly slow the progress of cognitive decline, allowing patients increased independence. The drugmaker's announcement revealed that the drug succeeded in halting early AD progression in nearly half of the participants, slowing cognitive decline rates by 35% compared to control participants. Donanemab is an antibody that targets protein...

An experimental Alzheimer's drug developed by Eli Lilly and Co (LLY.N) slowed cognitive decline by 35% in a closely watched late-stage trial, the company said on Wednesday, raising hopes for a second effective treatment for the brain-wasting disease. (excerpt) The drug, donanemab, met all goals of the trial. It slowed progression of Alzheimer's by 35% to 36% compared to a placebo in 1,182 people diagnosed with early-stage disease based on scans showing brain deposits of amyloid protein and intermediate levels of tau protein, Lilly said.

Treatment involves adult patients with severe alopecia areata Eli Lilly has announced that the Medicines and Healthcare products Regulatory Agency (MHRA) has granted marketing authorisation for baricitinib – also known as Olumiant – for the treatment of severe alopecia areata in adult patients. Marketing authorisation was based on BRAVE-AA1 and BRAVE-AA2 studies which both used the Severity of Alopecia Tool (SALT) score and both met the primary endpoint among the proportion of patients. Meanwhile, achievement of full regrowth or regrowth with minimal gaps in eyebrow and eyelash hair was also seen, with baricitinib, for patients who at baseline had significant...

Eli Lilly and Company, which employs more than 10,000 people in the Hoosier state, says it'll 'be forced to plan for more employment growth outside of our home state.' The Indiana-based pharmaceutical giant made the revelation in a statement on Saturday following the passing of a near-total ban on abortion in the state. Eli Lilly is the manufacturer of drugs such as Prozac and Cymbalta. On Friday, Indiana Gov. Eric Holcomb signed Senate Bill 1 into law making his state the first to institute an abortion ban since the Supreme Court's decision to overturn Roe v. Wade. The ban, which...

Here’s one deprivation the Russian people probably weren’t expecting. American drugmaker Eli Lilly has decided to halt export of all non-essential drugs to Russia, including its blockbuster erectile dysfunction drug, Cialis.The drugmaker told the FT that while it would continue to supply drugs for life-threatening illnesses, it will suspend all marketing, drug trials and investment in Russia, along with all non-essential meds, which they will no longer export. This marks the first time a US drugmaker has decided to pull its business from Russia since the start of the invasion of Ukraine. “For nearly 150 years, Lilly has worked to...

Indiana-based Eli Lilly and Company reported on February 3, 2022, it recently submitted a request for Emergency Use Authorization to the U.S. FDA for bebtelovimab, an investigational anti-SARS-CoV-2 Monoclonal Antibody (mAbs). Bebtelovimab, which neutralizes the SARS-CoV-2 spike glycoprotein receptor-binding domain-specific antibody, is being evaluated to treat mild-to-moderate COVID-19 in adults and pediatric patients 12 years of age and older. Lilly's recent financial disclosure says 'authentic virus analysis of bebtelovimab confirmed earlier pseudovirus findings, which demonstrated bebtelovimab neutralizes coronavirus variants of concern, including Omicron.' The U.S. NIH's OpenData Portal Therapeutic Activity Explorer separately confirmed bebtelovimab's effectiveness against Omicron as of February...

WASHINGTON (AP) — As strained U.S. hospitals brace for a new surge of COVID-19 cases caused by the fast-spreading omicron variant, doctors are warning of yet another challenge: the two standard drugs they’ve used to fight infections are unlikely to work against the new strain. For more than a year antibody drugs from Regeneron and Eli Lilly have been the go-to treatments for early COVID-19, thanks to their ability to head off severe disease and keep patients out of the hospital. But both drugmakers recently warned that laboratory testing suggests their therapies will be much less potent against omicron, which...

Eli Lilly and Company's experimental intravenous drug donanemab could slow the cognitive decline of patients with Alzheimer's disease, according to early clinical trial results, published in The New England Journal of Medicine on Saturday. The study included 257 patients with early symptomatic Alzheimer's disease; 131 received donanemab, while 126 received a placebo. The researchers found donanemab slowed the decline of cognition and daily function in Alzheimer's patients by 32% after 76 weeks, compared to those who received a placebo. Taken over 18 months, that 32% slowing of decline could be noticeably impactful for Alzheimer's patients, noted Maria Carrillo, chief science...

New data from phase 3 trials of monoclonal antibodies for patients with recent COVID-19 diagnoses, or at high risk for SARS-CoV-2 infection, could move the needle on clinician acceptance of the treatments, experts say. Two monoclonal antibody formulations, Eli Lilly's bamlanivimab and Regeneron's cocktail of two antibodies, casirivimab and imdevimab, received emergency use authorizations from the US Food and Drug Administration in November to treat mild to moderate COVID-19 in outpatients. But current recommendations from the Infectious Diseases Society of America's COVID-19 treatment and guideline panel, based on data from a phase 2 trial of bamlanivimab, suggest against the routine...

Big Pharma did not like Donald Trump, but they certainly like Joe Biden – especially now. In an ongoing frenzy to undo everything Trump did over the last four years, Joe Biden froze a December rule aimed at lowering prescription drug prices for insulin and epinephrine. On Thursday, Biden’s Department of Health and Human Services announced the new rule would be put on hold, along with several other Trump-era orders pending a 60 day review, The Federalist reports. Biden Chief of Staff Ron Klain directed federal agencies on Wednesday to pause orders that had been signed and published by Trump’s...

Dr. Leon R. Kass, the Addie Clark Harding Professor Emeritus in the Committee on Social Thought and the College at the University of Chicago and former chairman of the President’s Council on Bioethics under former President George W. Bush, has written a report entitled “The Meaning of Life – In the Laboratory”. Kass discusses the morality surrounding the US government’s funding of “research on human embryonic stem cells, cells derived from early embryos produced by in vitro fertilization in assisted-reproduction clinics.” According to the report, the use of human embryos is justified by the advancements of science which demands that...

PIERRE — State Attorney General Larry Long announced Thursday that South Dakota has joined with other states and the federal government and reached a $1.4 billion settlement with Eli Lilly and Co., to settle allegations it engaged in an off-label marketing campaign that improperly promoted the anti-psychotic drug, Zyprexa. Eli Lilly will pay the states and the federal government a total of $800 million in damages and penalties to compensate Medicaid and various federal health care programs for harm suffered as a result of this conduct. South Dakota’s total settlement recovery is $1.4 million. Of that amount, South Dakota will...

A third pharmaceutical giant said Sunday it is being investigated by Britain's Serious Fraud Office (SFO) over alleged breaches of the United Nations oil-for-food programme in Saddam Hussein's Iraq. Eli Lilly and Company Limited said it had been asked to hand over documents to the SFO, a day after British peer GlaxoSmithKline (GSK) and Anglo-Swedish firm AstraZeneca announced they had received similar requests.

OXFORD, Miss. - Mississippi filed a lawsuit Monday against Eli Lilly and Co., alleging improper sales and marketing of the anti-psychotic prescription drug Zyprexa. The lawsuit was filed in Lafayette County Circuit Court. Tim Balducci of the Langston Law Firm in Booneville, named a special assistant attorney general to handle the case, said the lawsuit seeks to recover money the state spent to purchase Zyprexa to treat symptoms for which the drug has not been approved. It also seeks money spent in providing health care to certain Medicaid recipients who allegedly suffered injuries or illnesses - such a diabetes -...

Health and Science Correspondent WASHINGTON (Reuters) - Suicide rates among the youngest and oldest Americans have steadily declined since the late 1980s, U.S. researchers reported on Thursday in a finding that contradicts popular conceptions that rates were rising. The study suggests that new antidepressant drugs may not raise the risk of suicide after all, the researchers said, but they acknowledge they are mystified by what might be causing the decline, because it is not affecting people aged 25 to 64. "For 40 years adolescent suicide rates rose," said Dr. Robert McKeown, a professor at the University of South Carolina's school...

The users call the drug Lizzie, the Big Brother or sometimes Gilly. On blogs they rave over its uncanny ability to melt away pounds, although some are wary of its side effects, which can include nausea and strange welts. The users are not fad dieters or methamphetamine addicts, but people with diabetes. And the subject of their rhapsodies is not a gray-market diet pill sold on late-night television but Byetta, a federally approved diabetes medicine, available only by prescription, whose popularity and sales have soared since its introduction last June. For diabetics, the weight loss caused by Byetta comes as...

AP MEDICAL WRITER KISSIMMEE, Fla. -- Women who have higher natural estrogen levels also may have a higher risk of stroke - a novel finding that suggests a possible new way to prevent this deadly disease, doctors reported Friday. More study is needed to confirm these results, but they fit with much of what is already known about hormones, said several experts who were not connected with the new work. "This is really interesting," said Dr. JoAnn Manson, a women's health researcher and chief of preventive medicine at Harvard-affiliated Brigham and Women's Hospital in Boston. "These findings would be consistent...

WHAT?ARE YOU CRAZY? © 2004 B. K. Eakman A new nationwide initiative has been quietly in the making since 2002. Conceived in Texas, apparently with President George W. Bush’s enthusiastic blessing, there now exists some 27 sites around the country piloting various parts of it.Nationally, however, the proposed legislation earned barely a blip on the radar screen — the project is so hush-hush that two officials were sacked for speaking to the press about it — until mid-July, when the House Appropriations Committee approved $20 million in new federal monies to begin nationwide implementation. The New Freedom Initiative — a...

ALEXANDRIA, VA – (September 2, 2005) The Indianapolis-based Lilly Endowment Inc. has provided a $10 million gift to The Salvation Army to assist with on-going relief efforts in the aftermath of Hurricane Katrina. The funds are the largest single gift to The Salvation Army designated for Hurricane Katrina relief efforts. One hundred percent of every dollar contributed to The Salvation Army’s Emergency Disaster Relief Fund is sent directly to the disaster location. “Lilly Endowment is pleased to make this grant to The Salvation Army, which time and time again has effectively delivered aid in times of great need,” said N....