For patients undergoing total knee arthroplasty (TKA), treatment with diosmin—a flavonoid supplement derived from citrus fruits—reduced swelling of the knee and leg and some measures of associated pain can be achieved, reports a clinical trial. Swelling is a common problem in patients undergoing TKA, and one that contributes to pain and patient dissatisfaction. Currently, there are no effective medication choices to reduce swelling after TKA. Diosmin—often in combination with a related flavonoid called hesperidin—has been used to reduce swelling of the limbs in patients with venous disorders. The exploratory study included 330 patients undergoing TKA at 13 university-affiliated hospitals. Patients...