It's not quite the ‘elephant in the room’, but an 18 megadalton viral assembly is perhaps the biggest thing in the mass spectrometer (MS). Dutch and US researchers have used quadrupole time-of-flight (QToF) native MS to investigate intact capsids from a bacteriophage – a virus that infects bacteria. While there is theoretically no upper limit on the mass of a particle that might be analysed using ToF MS, the work is far from trivial in breaking through the record.The late John Fenn shared the 2002 Nobel prize in chemistry for his pioneering work on electrospray ionisation techniques in mass...