Overuse of antibiotics has accelerated the development of bacterial resistance to conventional drugs, a global health crisis projected to result in more than 10 million deaths annually by 2050. The multidrug-resistant bacterium Pseudomonas aeruginosa accounts for approximately one-fifth of hospital-acquired pneumonia cases and is associated with severe illness and increased mortality. Nitric oxide is a therapeutic gas that researchers helped establish as a life-saving therapy for hundreds of thousands of newborns with congenital heart disease. Nearly 30 years later, investigators report that high-dose inhaled nitric oxide (iNO) demonstrates potential antimicrobial activity in preclinical models and is safe and feasible in...