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Investigators recently uncovered key insights into newly defined rejection entities in kidney transplantation that may offer improved patient risk categorization post-transplant. Kidney transplant rejection continues to threaten the long-term success of kidney transplants, with microvascular inflammation (inflammation within capillaries) playing a pivotal role in graft failure. Due to its complex nature, this inflammation poses a major challenge in clinical practice. In response, the international Banff classification—the global standard for diagnosing transplant rejection—has redefined antibody-mediated rejection diagnostics by introducing two new categories of microvascular inflammation: mild microvascular inflammation with probable antibody-mediated rejection and microvascular inflammation in the absence of antibody-mediated responses....

Patients who have suffered a heart attack should immediately be offered a combination of cholesterol lowering drugs with statins and ezetimibe, according to research. The study showed that people with acute coronary syndrome (ACS), which includes those who have experienced a heart attack or unstable angina, are 47% less likely to die within three years if they start taking a high dose statin and ezetimibe straight away, compared to those only taking a high dose statin. Researchers say that if treatment guidelines are changed to reflect these findings, it could prevent many thousands of deaths each year. The study included...