Free Republic

An article discusses the multifactorial nature of obesity, highlighting its association with chronic low-grade inflammation, or meta-inflammation, which contributes to metabolic disorders. Pyruvate was found to inhibit adipogenic differentiation in vitro and significantly prevent HFD-induced weight gain and inflammation in mice. The study underscores pyruvate's potential as a therapeutic option for obesity, given its previous clinical use and safety. Key findings from the study include: Pyruvate reduced intracellular lipid and triglyceride accumulation, indicating its effectiveness in suppressing adipogenesis across different cell types. In vivo experiments with male mice indicated that pyruvate administration significantly prevented HFD-induced weight gain and central adiposity....

No need to bid. A marketing firm with close ties to President Obama and his political campaigns was given the lucrative job of designing Michelle Obama’s “Let’s Move” anti-obesity logo without having to go through the government contract bidding route. Judicial Watch reported the firm, Shepardson, Stern & Kaminsky, was awarded the $100,000 job, in violation of federal contracting rules. And that’s not just Judicial Watch’s interpretation of law — federal officials admitted the deal was an “unauthorized commitment,” in documents obtained by the government watchdog from a Freedom of Information Act request. In a written statement, Judicial Watch reported...

US researchers have developed a vaccine which prevents weight gain in rats, offering clues about human treatments. The vaccine prompts the body to produce antibodies against ghrelin, a hormone that stimulates hunger and weight gain. Vaccinated rats put on less weight while eating the same amount as those which did not have the jab.