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A study showed a significant overall survival benefit with ribociclib plus endocrine therapy for postmenopausal patients with hormone receptor-positive (HR+) human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer. The randomized Phase III MONALEESA-2 trial is the first demonstration of a survival advantage with a front-line CDK4/6 inhibitor in postmenopausal patients with HR+/HER2- advanced breast cancer. The results showed a median survival of 63.9 months with front-line ribociclib, a CDK4/6 inhibitor, and the aromatase inhibitor letrozole, compared to 51.4 months with hormone therapy alone. The estimated six-year survival rate was 44.2% with ribociclib, compared with 32% for placebo. Previously...

The former “Empire” actor was convicted on five counts of felony disorderly conduct for lying to police after his eight-day trial late last year. Smollett, 39, is facing up to three years in jail for the crimes but before Judge James Linn could hand down his sentence, he had to rule on a Hail Mary motion to vacate the charges filed by the artist’s legal team last month. Tina Glandian, one of Smollett’s attorneys, argued the court made 13 critical errors and constitutional violations, including wrongfully dismissing jurors based on their race and sexuality and depriving the actor of his...

Meta Platforms will allow Facebook and Instagram users in some countries to call for violence against Russians and Russian soldiers in the context of the Ukraine invasion, according to internal emails seen by Reuters on Thursday, in a temporary change to its hate speech policy. The social media company is also temporarily allowing some posts that call for death to Russian President Vladimir Putin or Belarusian President Alexander Lukashenko in countries including Russia, Ukraine and Poland, according to a series of internal emails to its content moderators. These calls for the leaders' deaths will be allowed unless they contain other...

Russian President Vladimir Putin invoked World War II to justify Russia's invasion of Ukraine, saying in televised remarks last week that his offensive aimed to "denazify" the country — whose democratically elected president is Jewish, and lost relatives in the Holocaust. "The purpose of this operation is to protect people who for eight years now have been facing humiliation and genocide perpetrated by the Kyiv regime," he said, according to an English translation from the Russian Mission in Geneva. "To this end, we will seek to demilitarize and denazify Ukraine, as well as bring to trial those who perpetrated numerous...

Despite desperate please from Ukrainian President Volodymyr Zelensky and pressure from lawmakers at home, President Biden killed the Polish plan to transfer MiG-29 jets to Ukraine, fearing the deal might be viewed as an escalation of tensions by Vladimir Putin. The diplomatic blunder that began with a top European Union diplomat promising the jets to Ukraine ended when Poland suggested it would give the jets to the U.S. to deliver to Ukraine, and the U.S. said that was Poland's responsibility. Then, U.S. defense officials killed the project entirely, saying they would not support either transferring the jets themselves or backing...

There’s a reason that stickers with Biden’s face and an “I did that” caption are ubiquitous on gas pumps around the country.Gas price averages keep skyrocketing upward in line graphs resembling Mount Everest, and it’s astonishing in light of the rosy way President Joe Biden painted the state of our union just last week during his eponymous speech.It’s almost comical to consider how Biden proudly and delusionally compared himself to his predecessor, under whom gas prices lived in the $2.00 territory — especially when you consider that Trump’s predictions about Biden being a presidential disaster have proved to be spot-on.Donald...

The World Health Organization has confirmed the emergence of a new variant, dubbed deltamicron or deltacron — a combination of delta and omicron. Five things to know: 1. Three COVID-19 infections in southern France were identified with a delta 21J/AY.4-omicron 21K/BA.1 recombinant, or deltamicron, according to a preprint published March 8 in MedRxiv. The study, which has yet to be peer-reviewed, found that the hybrid genome has signature mutations of the two lineages. It's similar to cases reported for 15 other patients sampled since January 2022 in Europe. The mutation is misidentified with current PCR variant screening, so researchers designed...

The U.S. Coast Guard is warning about the hazards of transporting discarded lithium batteries after a container illegally loaded them caught fire while en route to the Port of Virginia, where it was set to be loaded onto a ship.

We owe the Ukrainians nothing, yet our garbage ruling class is demanding that we brace ourselves for unspecified “sacrifices” for their sake just as they have every time they have made some foreign policy screw-up. We normals are their janitors – we get to clean up their messes and no one is ever held accountable. No thanks. I like Ukrainians and, while the whole dispute is much more complex than “PUTIN BAD,” there’s no excuse for the brutal invasion and I hope the Russians lose. To the extent that we might spend some money on bullets and Javelins for guerillas...

Troubling video showing an off-duty Kenosha cop putting his knee on the neck of a 12-year-old girl while breaking up a fight at a middle school has sparked fury in the Wisconsin city where Kyle Rittenhouse killed two people in the wake of the police shooting of Jacob Blake. The 17-second viral clip shows the officer trying to separate two girls before he was knocked to the ground by the sixth-grader in a rainbow sweatshirt in the cafeteria of Lincoln Middle School last Friday. He then scrambles to his feet and restrains the pre-teen by putting his knee on her...

The California Army National Guard commander on Sunday sent a memorandum to soldiers serving in the California Army National Guard — which is partnered with Ukrainian forces under the State Partnership Program — asking them to “stand ready.” The subject of the memorandum, obtained by Breitbart News, and issued by Army Maj. Gen. Laura L. Yeager, was “Letter to the Field — Ukraine.” “We cannot predict what our role may be at home or abroad, therefore we must stand ready. We ask each of you to self-assess and seize the initiative to improve your personal readiness,” Yeager wrote. The memorandum...

The Animated History of Ukraine17:01 minutes total but it's a historical lecture in a cartoon format so easy to watch.

Documents have dropped that support Russia’s claim that the United States government is funding biolabs in Ukraine to “create bioagents that can target certain ethnic groups.” In other words, the U.S. regime of Sleepy Joe Biden has been overseeing a bioweapons factory to carry out ethnic genocide. The newly dropped documents show agents of the United States Department of Agriculture (USDA) and Centers for Disease Control and Prevention (CDC) involved in the Ukraine biolabs. As we first reported at NATIONAL FILE, archived U.S. government records show that the United States Department of Defense has long been funding biolabs in Ukraine...

While speaking to reporters on Tuesday, Sen. Joe Manchin (D-WV) said the Biden administration hasn’t done enough to combat inflation and called for increasing U.S. energy production to combat high gas prices. Fox Business Correspondent Hillary Vaughn asked, “And on gas prices, the president said, two days ago, we can’t do much to bring them down. Has he given up on trying to fix this problem?”

On the 99th day of a contentious lockout, Major League Baseball and the players’ union reached a tentative labor agreement for the 2022 season on Thursday. Once in doubt, a full 162-game regular season will be played. Spring training, which is normally six weeks and was originally scheduled to begin in mid-February, will open this weekend.

WASHINGTON (AP) — The IRS said Thursday it plans to hire 10,000 new workers to help reduce a massive backlog that the government says will make this tax season the most challenging in history. The agency released a plan to work down the tens of millions of filings that includes speeding up the traditionally slow hiring process, relying more on automated processes and bringing on more contract workers to help with mailroom and paper processing. Getting it done will be the big challenge, tax experts say. The agency faces a backlog of around 20 million pieces of correspondence, which is...

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Russia’s full-scale attack on Ukraine – justified by Moscow as a response to its neighbour’s tilt to the West and Nato – has many pondering whether Beijing would follow suit in Taiwan. Beijing has long felt that Washington is using the self-ruled island as part of a strategy to undermine and contain its rival – accusing the US of disrespecting its sovereignty by backing the Taiwanese pro-independence camp. Beijing regards the island as part of its territory, which it intends to recover by force if necessary, and “Today Ukraine, Tomorrow Taiwan” quickly emerged as a Taiwanese catchphrase after the Russian...

A young Russian pianist who was set to perform with the Montreal Symphony Orchestra this week has been struck from the schedule after protest. However, the orchestra maintained its praise for 20-year-old Alexander Malofeev, who has been outspoken against the invasion of Ukraine, where he said he has some family members. "The OSM feels that it would be inappropriate to receive Mr. Malofeev this week," wrote a spokesperson for the orchestra, Pascale Ouimet, in a statement. "We continue, however, to believe in the importance of maintaining relationships with artists of all nationalities who embrace messages of peace and hope. We...

The Newsom administration is proposing large bonuses to retain juvenile prison employees as the system prepares to close next year.