Posted on 05/29/2024 12:49:48 PM PDT by Red Badger
The world's first human trial of a drug that can regenerate teeth will begin in a few months, less than a year on from news of its success in animals. This paves the way for the medicine to be commercially available as early as 2030.
The trial, which will take place at Kyoto University Hospital from September to August 2025, will treat 30 males aged 30-64 who are missing at least one molar. The intravenous treatment will be tested for its efficacy on human dentition, after it successfully grew new teeth in ferret and mouse models with no significant side effects.
"We want to do something to help those who are suffering from tooth loss or absence," said lead researcher Katsu Takahashi, head of dentistry and oral surgery at Kitano Hospital. "While there has been no treatment to date providing a permanent cure, we feel that people's expectations for tooth growth are high."
Following this 11-month first stage, the researchers will then trial the drug on patients aged 2-7 who are missing at least four teeth due to congenital tooth deficiency, which is estimated to affect 1% of people. The team is recruiting for this Phase IIa trial now.
Researchers are then looking at expanding the trial to those with partial edentulism, or people missing one to five permanent teeth due to environmental factors. The incidence of this varies from country to country, but it's estimated around 5% of Americans are missing teeth, with a much higher incidence among older adults.
The medicine itself deactivates the uterine sensitization-associated gene-1 (USAG-1) protein, which suppresses tooth growth. As we reported in 2023, blocking USAG-1's interaction with other proteins encourages bone morphogenetic protein (BMP) signaling, which triggers new bone to generate.
(Excerpt) Read more at newatlas.com ...
Hold the mRNA please ✋️
“Hockey Players all over the world rejoice!”
And dental implant companies weep.
Probably loaded with DNA.
Interesting, both from a scientific and personal perspective.
I hope it has an off-switch, though.
People will be gnawing on hickory sticks to keep their teeth worn down like squirrels...............
So men have a uterine gene.
Interesting.
I would hope this treatment wouldn’t regenerate wisdom teeth that had been removed, or teeth that were removed to make room for orthodontic alignments.
It should be added to Meth.
No side effects in ferrets and mice. Just wait til one of these 30 guys sprouts a molar in the middle of his forehead
Some cysts already form teeth. (I do NOT recommend looking at pictures online). Now add murdeRNA drugs to the mix and people will have cysts all over with teeth in them.
Which reminds me ... I recently ran across an article on How To: Eat a Beaver. I feel that it is a moral imperative that I share it with the wonderful folks of FR. It is, the author claims, clean and sweet-smelling.
;'}
One question I was going to ask God when I get up there was why not three sets of teeth. One at birth to two, one at 7-10 and one at 45.
my dentist told me about this 5 or 10 years ago. I didn’t believe him.
“patients aged 2-7 who are missing at least four teeth due to congenital tooth deficiency, which is estimated to affect 1% of people”
One percent of people? Has anyone even heard of this before?
split tail?
Maybe in West Virginia......................
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