Posted on 04/12/2023 5:36:19 AM PDT by Red Badger
An in-development COVID-19 nasal vaccine that contains a live but weakened coronavirus outperformed several other types of shots in a preclinical study — suggesting that there may be a less painful and more effective way to protect against COVID-19.
The challenge: More than 30 COVID-19 vaccines have been authorized for use in at least one country, and while they’re all designed to help the immune system recognize the coronavirus so that it can stop an infection, they do so in a variety of ways.
The mRNA vaccines, for example, deliver instructions that teach our cells to make the coronavirus’ spike protein, and protein-based shots just inject the spike directly. Adenovirus vaccines use the shells of a cold virus as carriers for the spike instructions, while inactivated vaccines use whole, killed coronaviruses.
Live attenuated vaccines are typically highly effective, durable, and can be stored in refrigerators.
In search of: One thing missing from our COVID-19 vaccine arsenal is a live attenuated vaccine, which uses a live but weakened version of the virus to train the immune system to fight the real thing.
These vaccines aren’t without limitations — because it is possible that the attenuated virus might retain its toxicity in the body, they might not be the best option for people who are immunocompromised.
However, they’re typically highly effective, durable, and can be stored in refrigerators, which makes them easier to distribute than shots that must be frozen. They’re also well understood, as we use them to protect against flu, smallpox, measles, and many other diseases.
What’s new? Several groups are now working to get a live attenuated vaccine for COVID-19 authorized, and a team in Germany has just published positive preclinical data on their candidate, sCPD9, which is delivered via a nasal spray, rather than an injection.
“Overall protection from virus replication, tissue damage, and lung inflammation were significantly better.”
NOUAILLES ET AL. This approach creates what’s known as “local immunity” in the mucus membranes of the nose and mouth, which can prevent the coronavirus from entering the body at all. With injected vaccines, the immune system typically doesn’t spring into action until the coronavirus is in the body, and a person might have already spread the virus to others by then.
Nasal vaccines also have the benefit of being less painful (and, for some, less scary) than injections, which could encourage more people to get vaccinated.
How it works: For their study, the German researchers used hamsters to compare their live attenuated vaccine against BNT162b2, an approved mRNA vaccine developed by BioNTech and Pfizer, and Ad2-Spike, an in-developed adenovirus-based vaccine.
The hamsters were given two doses of vaccine 21 days apart — these were either two doses of the live attenuated vaccine, two doses of the mRNA vaccine, two doses of the adenovirus-based vaccine, or the mRNA vaccine followed by the live attenuated vaccine.
“Our goal is to rapidly scale-up production and advance clinical development.”
VLADIMIR CMILJANOVIC Fourteen days after the second dose, the hamsters were challenged with the coronavirus. The researchers then looked at tissue samples from the animal’s nasal passages and lungs, and discovered that the live attenuated vaccine out performed the others at protecting against infection.
“Overall protection from virus replication, tissue damage, and lung inflammation were significantly better in sCPD9-vaccinated animals,” they wrote.
Looking ahead: A handful of live attenuated vaccines for COVID-19 have made it to human testing — NY-based biotech startup Codagenix’s candidate is in phase 3 trials — and the German researchers hope theirs will be the next to take that major step closer to authorization.
To that end, they’ve teamed up with Swiss startup RocketVax AG to prepare their vaccine for phase 1 clinical trials.
“Our goal is to rapidly scale-up production and advance clinical development towards market access to provide protection against post-COVID symptoms for all,” said RocketVax CEO Vladimir Cmiljanovic.
Flooding the air with it.
Waiting for the democrat/media/big pharma/Faux-xi cheerleaders on here to say the death serum is perfectly safe with 98% efficacy.
I think I had it twice- once at begging of covid, and again a year or so later when it was confirmed by test (if the test was accurate). The 2nd time was likely omicron which wasn’t as bad as the first case of covid I’m pretty sure we all had in our household. THe omicron was not tOo bad- not pleasant, but not too bad. Interestingly we all got “the crud” as we called it, about 2 months before covid was declared. A lot of folks got it around then too. It was pretty bad.
Our family should be immune for a good long time, or at least get much less symptoms of we et a variant hopefully. The natural “immunity” is as you say much better- and anyways, with a survivability of nearly 100%, we love our odds!
Big Pharma’s goal is to fill every human being with deadly spike proteins.
That crap is not for covid. They have something in those things they are going to use to help control us.
They seem to be insistent on getting that clot shot formula into every human one way or the other.
Thing is, and the worst part, is that people haven’t banded together to roundup these criminals.
My daughter and hubby got it about 2 months ago. Took 17 days till she got a negative test. Deadly ill...but stuck it out at home...thank God. She said she’s finished with her body being poisoned with “cures”.
I’ve noticed the different nurse skill levels, too. Some are so good you get the shot and it’s over before you know it. Others are more “Oooh...” sting, but not quite an “Ouch.”
The pain with the flu vaccine comes in the next 24 hours. I sometimes get a slightly sore injection site, but it’s usually hardly noticeable.
[[even Bubonic Plague...............]]
Which is still around, as is pneumonic plague. A trapper caught a fox once out West, threw the fox in the back seat to bring it home- ended up loaning his car out Hat evening, and botH he and the loanee got the plague and died. there have been other Instances too
I had one nurse that was so good I didn’t even know she had done it because I was distracted for a second......................
[[The Nasal Covid-19 vaccine does not use mRNA technology]]
Do you know that for sure? I think a lot of folks who are high risk for comp,ications due to covid would take the spray if they knew for sure it was not mRNA
[[Maybe they are referring to the pain of myocarditis and pericarditis? Getting a jab is hardly painful]]
Lol, or maybe he pain of “died suddenly”
[[You have to ask yourself, why this big push to get people vaxxed one way or another if it isn’t such a big deal?]]
Exactly! And even more suspicious is their incessant drive to vaccinate kid’s and toddlers who have an almost 0 chance of dying from covid. It’s very suspicious indeed.
And again, especially suspicious when tH3 left couldn’t give two poos about the elderly. They proved this when they intentionally sent sick people into nursing homes knowing dang well 10’s of 1000s would die as a result
Leaning Right wrote: “I trust traditional vaccines. But I’m of the opinion that there are liars and grifters on both sides of the current Covid vaccine debate. I have yet to decide who’s lying more. So I’m neutral here.”
Since this is a ‘traditional’ vaccine, you’ll be taking it right?
Turns you into a Jimmy Durante lookalike ?
[[They’re researching putting it in veggies, using it in domestic food animals]]
AnothEr very suspicious thIng!- all this pushing for vaccination over something that is only 99.4% overall survivable (witH the variants being even more survivable overall than he original covid 19)
The lefts obsession with vaccination for covid is bizarre- hey are still run ing commercials to get thE young vaccinated. Some nations thouh are abanding hr vaccines for children beczuse of the risk- not our nation thouh.
> Since this is a ‘traditional’ vaccine, you’ll be taking it right? <
To me, a “traditional” vaccine is more that just one with traditional ingredients. It must be well-tested over a period of time. Please take another look at the last sentence of my post #60. “Neutral” means not getting involved, one way or the other. I’m on the sidelines for now.
The most important reminder which makes this whole article a joke is that the mRNA covid jabs did not prevent people from getting covid.
So why are they doubling down with the same failure other than what is in them has nothing to do with covid or any virus?
Getting the ignorant sheep ready for their next upgrade.
Amazing how many fall for it.
I certainly wouldn’t be first, but I did take the J&J because of its traditional format.
My neighbors waited and got the J&J, and both were sick for two weeks.....................
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