Posted on 04/12/2023 5:36:19 AM PDT by Red Badger
An in-development COVID-19 nasal vaccine that contains a live but weakened coronavirus outperformed several other types of shots in a preclinical study — suggesting that there may be a less painful and more effective way to protect against COVID-19.
The challenge: More than 30 COVID-19 vaccines have been authorized for use in at least one country, and while they’re all designed to help the immune system recognize the coronavirus so that it can stop an infection, they do so in a variety of ways.
The mRNA vaccines, for example, deliver instructions that teach our cells to make the coronavirus’ spike protein, and protein-based shots just inject the spike directly. Adenovirus vaccines use the shells of a cold virus as carriers for the spike instructions, while inactivated vaccines use whole, killed coronaviruses.
Live attenuated vaccines are typically highly effective, durable, and can be stored in refrigerators.
In search of: One thing missing from our COVID-19 vaccine arsenal is a live attenuated vaccine, which uses a live but weakened version of the virus to train the immune system to fight the real thing.
These vaccines aren’t without limitations — because it is possible that the attenuated virus might retain its toxicity in the body, they might not be the best option for people who are immunocompromised.
However, they’re typically highly effective, durable, and can be stored in refrigerators, which makes them easier to distribute than shots that must be frozen. They’re also well understood, as we use them to protect against flu, smallpox, measles, and many other diseases.
What’s new? Several groups are now working to get a live attenuated vaccine for COVID-19 authorized, and a team in Germany has just published positive preclinical data on their candidate, sCPD9, which is delivered via a nasal spray, rather than an injection.
“Overall protection from virus replication, tissue damage, and lung inflammation were significantly better.”
NOUAILLES ET AL. This approach creates what’s known as “local immunity” in the mucus membranes of the nose and mouth, which can prevent the coronavirus from entering the body at all. With injected vaccines, the immune system typically doesn’t spring into action until the coronavirus is in the body, and a person might have already spread the virus to others by then.
Nasal vaccines also have the benefit of being less painful (and, for some, less scary) than injections, which could encourage more people to get vaccinated.
How it works: For their study, the German researchers used hamsters to compare their live attenuated vaccine against BNT162b2, an approved mRNA vaccine developed by BioNTech and Pfizer, and Ad2-Spike, an in-developed adenovirus-based vaccine.
The hamsters were given two doses of vaccine 21 days apart — these were either two doses of the live attenuated vaccine, two doses of the mRNA vaccine, two doses of the adenovirus-based vaccine, or the mRNA vaccine followed by the live attenuated vaccine.
“Our goal is to rapidly scale-up production and advance clinical development.”
VLADIMIR CMILJANOVIC Fourteen days after the second dose, the hamsters were challenged with the coronavirus. The researchers then looked at tissue samples from the animal’s nasal passages and lungs, and discovered that the live attenuated vaccine out performed the others at protecting against infection.
“Overall protection from virus replication, tissue damage, and lung inflammation were significantly better in sCPD9-vaccinated animals,” they wrote.
Looking ahead: A handful of live attenuated vaccines for COVID-19 have made it to human testing — NY-based biotech startup Codagenix’s candidate is in phase 3 trials — and the German researchers hope theirs will be the next to take that major step closer to authorization.
To that end, they’ve teamed up with Swiss startup RocketVax AG to prepare their vaccine for phase 1 clinical trials.
“Our goal is to rapidly scale-up production and advance clinical development towards market access to provide protection against post-COVID symptoms for all,” said RocketVax CEO Vladimir Cmiljanovic.
My thoughts exactly. They can then shove them …..
I get the regular flu vaccine shot, plus I had all the school vaxxes available at the time as a kid.
And when I was in the Marines I had every vax they could shoot into me, even Bubonic Plague...............
>>> This approach is very much more traditional
yes... i agree... sounds exactly what a vaccine is... a live but weakened version of the entire organism presented to the body for analysis.
At the same time, they talk about the snake bite as if it’s an alternate version of what a vaccine is, when it is nothing less than a biological weapon.
They will try that too!....................
Sure, trust them. And if your nasal passages rot out? Why, that is just from climate change.
“It’s a man-made synthetic virus.”
The Nasal Covid-19 vaccine does not use mRNA technology and is not a man-made synthetic virus. Instead, it uses a weakened form of the virus to stimulate an immune response.
Other vaccines that use a weakened form of virus include measles, mumps, rubella, chickenpox, yellow fever, and polio vaccines.
That's not what this article is about ... This article is about something that everyone on this forum would have recognized as a vaccine in 2019.
“a less painful and more effective way to protect against COVID-19.”
“Less painful”?? Huh?
Maybe they are referring to the pain of myocarditis and pericarditis? Getting a jab is hardly painful.
My mistake, they are different, but would you try them?
The first polio vaxxes injected live but weakened virus into people and some were not quite weakened enough and they got polio.................
I usually get the seasonal flu shot in the Fall, and it’s usually painless, but the last one I got in September was painful because the nurse was not paying attention to what she was doing...........................
Or cocaine......................
At least it’s not frankenmRNA. Maybe take a non-shot at it in a couple of years if it pans out. Not that my bout with covid was a big deal. It was actually more mild and of shorter duration than most of the common colds I normally get.
This is very old technology, not MRNA
I still don’t trust them, the first polio vax was defective.................
>>> The Nasal Covid-19 vaccine does not use mRNA technology and is not a man-made synthetic virus.
I was not addressing the nasal version. I was addressing their usage of the term “vaccine” and MRNA in the same sentence.
But here’s an interesting question, assuming this nasal vaccine proves to be both “Safe” and “Effective”.....
Will they mandate it along with, or over the MRNA versions?
Are these nasal vaccines made by Phizer? Maderna?... any of the MRNA manufacturers?
What I sense is an attempt to normalize what they have done with the MRNA tech.
I hope whoever is finally doing this right can actually save some lives.
Little late now though, considering most who didn’t take the jab already has natural immunity by now.
You have to ask yourself, why this big push to get people vaxxed one way or another if it isn’t such a big deal?
People at work had covid and say it wasn’t even as bad as a cold, and they were back at work in a couple of days.
There must be another reason they are pushing us to get this one way or another.................
I made the mistake of taking a nasal flu “shot.” I went through about three months of olfactory hallucinations (smelling things which weren’t there) and wound up going through an MRI looking for a brain tumor. Nothing there. I lost my sense of smell at month four and haven’t had it back in thirteen years. I get whiffs of stuff about two or three times a month, but it doesn’t stay.
Or. In am alternate universe the pharmaceutical/medical research/ medical industry/ partners in government have NOT shred every semblance of credibility. This vile parasitic and monolithic entity has sacrificed any trace of honesty decency or truth in an unending pursuit of money and political power. Science. Is this what Science is? Somehow you vapidly choose to ignore what has occurred most pressingly in the last 3 years and choose to spew platitudes like “anti vaxxer”. Shame on you a vile propagandist of the ilk of Google. Which side of the filthy fecal encrusted coin do you work? Government? Medical? Government education? Grant writing? What level of filth are you rolling about in to throw about “anti vaxxer”? This term is a root of global warming denier which is rooted in holicost denier. An Alinsky alliteration. Begone devil I shall not supper with thee!
They’re researching putting it in veggies, using it in domestic food animals.
They really really seem to want to get this mRNA crap into every person’s veins. Makes me wonder about the conspiracy theories about nano bots, graphene, creating hackable humans etc.
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