Posted on 04/12/2023 5:36:19 AM PDT by Red Badger
An in-development COVID-19 nasal vaccine that contains a live but weakened coronavirus outperformed several other types of shots in a preclinical study — suggesting that there may be a less painful and more effective way to protect against COVID-19.
The challenge: More than 30 COVID-19 vaccines have been authorized for use in at least one country, and while they’re all designed to help the immune system recognize the coronavirus so that it can stop an infection, they do so in a variety of ways.
The mRNA vaccines, for example, deliver instructions that teach our cells to make the coronavirus’ spike protein, and protein-based shots just inject the spike directly. Adenovirus vaccines use the shells of a cold virus as carriers for the spike instructions, while inactivated vaccines use whole, killed coronaviruses.
Live attenuated vaccines are typically highly effective, durable, and can be stored in refrigerators.
In search of: One thing missing from our COVID-19 vaccine arsenal is a live attenuated vaccine, which uses a live but weakened version of the virus to train the immune system to fight the real thing.
These vaccines aren’t without limitations — because it is possible that the attenuated virus might retain its toxicity in the body, they might not be the best option for people who are immunocompromised.
However, they’re typically highly effective, durable, and can be stored in refrigerators, which makes them easier to distribute than shots that must be frozen. They’re also well understood, as we use them to protect against flu, smallpox, measles, and many other diseases.
What’s new? Several groups are now working to get a live attenuated vaccine for COVID-19 authorized, and a team in Germany has just published positive preclinical data on their candidate, sCPD9, which is delivered via a nasal spray, rather than an injection.
“Overall protection from virus replication, tissue damage, and lung inflammation were significantly better.”
NOUAILLES ET AL. This approach creates what’s known as “local immunity” in the mucus membranes of the nose and mouth, which can prevent the coronavirus from entering the body at all. With injected vaccines, the immune system typically doesn’t spring into action until the coronavirus is in the body, and a person might have already spread the virus to others by then.
Nasal vaccines also have the benefit of being less painful (and, for some, less scary) than injections, which could encourage more people to get vaccinated.
How it works: For their study, the German researchers used hamsters to compare their live attenuated vaccine against BNT162b2, an approved mRNA vaccine developed by BioNTech and Pfizer, and Ad2-Spike, an in-developed adenovirus-based vaccine.
The hamsters were given two doses of vaccine 21 days apart — these were either two doses of the live attenuated vaccine, two doses of the mRNA vaccine, two doses of the adenovirus-based vaccine, or the mRNA vaccine followed by the live attenuated vaccine.
“Our goal is to rapidly scale-up production and advance clinical development.”
VLADIMIR CMILJANOVIC Fourteen days after the second dose, the hamsters were challenged with the coronavirus. The researchers then looked at tissue samples from the animal’s nasal passages and lungs, and discovered that the live attenuated vaccine out performed the others at protecting against infection.
“Overall protection from virus replication, tissue damage, and lung inflammation were significantly better in sCPD9-vaccinated animals,” they wrote.
Looking ahead: A handful of live attenuated vaccines for COVID-19 have made it to human testing — NY-based biotech startup Codagenix’s candidate is in phase 3 trials — and the German researchers hope theirs will be the next to take that major step closer to authorization.
To that end, they’ve teamed up with Swiss startup RocketVax AG to prepare their vaccine for phase 1 clinical trials.
“Our goal is to rapidly scale-up production and advance clinical development towards market access to provide protection against post-COVID symptoms for all,” said RocketVax CEO Vladimir Cmiljanovic.
No. The they are live attenuated virus
I lost my sense of smell after sinus surgery back in 2008, and the doc said I might never get it back, but slowly it has returned, but not 100%.........................
It is for that reason that I believe the U.S. will disallow the nasal spray and continue to insist on the frankenshot.
I did get a flu shot last fall, and made the nurse show me the ampule to prove it was just for flu as I didn't trust her not to give me the combo with the clot shot mixed with it.
This old school; not mRNA.
I did too.................
Make whatever vax in whatever form you want. I don’t care how many, or for what reason. If you mandate it I will refuse. Loudly.
I see that now. Read it too fast the first time
Yes, voluntary only.................
Anybody even getting Cold-19 anymore? Talk about the Big Pharma cash cow.
I’m sure CoVid-24 will soon be here...................
They will never. let. this. go.
They are looking for the ‘Holy Grail’: a Universal Vaccine..................
DariusBane wrote: “Which side of the filthy fecal encrusted coin do you work? Government? Medical? Government education? Grant writing? What level of filth are you rolling about in to throw about “anti vaxxer”? This term is a root of global warming denier which is rooted in holicost denier.”
BTW, one of the oldest strategies on the internet is accusing someone of being paid for holding beliefs one disagrees with. You can tell when someone no longer has any factual comments. That’s when they resort to accusing someone of being paid.
Leaning Right wrote: “However, the medical community has damaged its credibility over the last three years. Like many others, I no longer trust everything they say. So I won’t be first in line for this new spray. But maybe later.”
Yet you believe the misinformation put out by grifters selling vaccine fear-pornograpy like Mercola, Malone, McCullough, etc.
Lets flood the nasal passages with toxic spike proteins. Much closer to the brain. What could possibly go wrong?
BTW…what virus?
Lol! “And twice as far with a Mason jar”
Hey had a spray way back in the begginning of the plandemic to do just that and it was quickly taken off the market in order to “study it”.
Doesn’t mean, at this point, I’d consider it.
But it’s not 10,000% out of bounds. Just 200%.
They’ve completely destroyed my trust.
Probably something as simple as a Listerine spray.
> Yet you believe the misinformation put out by grifters selling vaccine fear-pornograpy like Mercola, Malone, McCullough, etc. <
Do I believe those folks instead? Absolutely not. I have posted challenges to them on FR many times. One of the worst grifters not on your list is Dr. Sherri Tenpenny. She pushes anti-vax statements simply as a way to get people to attend her seminars at $600 a ticket.
I trust traditional vaccines. But I’m of the opinion that there are liars and grifters on both sides of the current Covid vaccine debate. I have yet to decide who’s lying more. So I’m neutral here.
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