Posted on 04/12/2023 5:36:19 AM PDT by Red Badger
An in-development COVID-19 nasal vaccine that contains a live but weakened coronavirus outperformed several other types of shots in a preclinical study — suggesting that there may be a less painful and more effective way to protect against COVID-19.
The challenge: More than 30 COVID-19 vaccines have been authorized for use in at least one country, and while they’re all designed to help the immune system recognize the coronavirus so that it can stop an infection, they do so in a variety of ways.
The mRNA vaccines, for example, deliver instructions that teach our cells to make the coronavirus’ spike protein, and protein-based shots just inject the spike directly. Adenovirus vaccines use the shells of a cold virus as carriers for the spike instructions, while inactivated vaccines use whole, killed coronaviruses.
Live attenuated vaccines are typically highly effective, durable, and can be stored in refrigerators.
In search of: One thing missing from our COVID-19 vaccine arsenal is a live attenuated vaccine, which uses a live but weakened version of the virus to train the immune system to fight the real thing.
These vaccines aren’t without limitations — because it is possible that the attenuated virus might retain its toxicity in the body, they might not be the best option for people who are immunocompromised.
However, they’re typically highly effective, durable, and can be stored in refrigerators, which makes them easier to distribute than shots that must be frozen. They’re also well understood, as we use them to protect against flu, smallpox, measles, and many other diseases.
What’s new? Several groups are now working to get a live attenuated vaccine for COVID-19 authorized, and a team in Germany has just published positive preclinical data on their candidate, sCPD9, which is delivered via a nasal spray, rather than an injection.
“Overall protection from virus replication, tissue damage, and lung inflammation were significantly better.”
NOUAILLES ET AL. This approach creates what’s known as “local immunity” in the mucus membranes of the nose and mouth, which can prevent the coronavirus from entering the body at all. With injected vaccines, the immune system typically doesn’t spring into action until the coronavirus is in the body, and a person might have already spread the virus to others by then.
Nasal vaccines also have the benefit of being less painful (and, for some, less scary) than injections, which could encourage more people to get vaccinated.
How it works: For their study, the German researchers used hamsters to compare their live attenuated vaccine against BNT162b2, an approved mRNA vaccine developed by BioNTech and Pfizer, and Ad2-Spike, an in-developed adenovirus-based vaccine.
The hamsters were given two doses of vaccine 21 days apart — these were either two doses of the live attenuated vaccine, two doses of the mRNA vaccine, two doses of the adenovirus-based vaccine, or the mRNA vaccine followed by the live attenuated vaccine.
“Our goal is to rapidly scale-up production and advance clinical development.”
VLADIMIR CMILJANOVIC Fourteen days after the second dose, the hamsters were challenged with the coronavirus. The researchers then looked at tissue samples from the animal’s nasal passages and lungs, and discovered that the live attenuated vaccine out performed the others at protecting against infection.
“Overall protection from virus replication, tissue damage, and lung inflammation were significantly better in sCPD9-vaccinated animals,” they wrote.
Looking ahead: A handful of live attenuated vaccines for COVID-19 have made it to human testing — NY-based biotech startup Codagenix’s candidate is in phase 3 trials — and the German researchers hope theirs will be the next to take that major step closer to authorization.
To that end, they’ve teamed up with Swiss startup RocketVax AG to prepare their vaccine for phase 1 clinical trials.
“Our goal is to rapidly scale-up production and advance clinical development towards market access to provide protection against post-COVID symptoms for all,” said RocketVax CEO Vladimir Cmiljanovic.
WHAT'S NEXT?
SUPPOSITORIES??????.......................
Up your nose with a rubber hose Ping!..............
Hacking your cells to create a foreign toxic substance is NOT a vaccine.
It’s a man-made synthetic virus.
It results in AUTO-IMMUNE disorders... drug induced AIDS!
I won’t be getting this version of the not-a-vaccine either.
Red Badger wrote: “Apparently they plan on putting that stuff in you all, in every orifice possible!”
Isn’t this exactly what some have been calling for, a ‘real’ vaccine which isn’t mRNA based. What’s to complain about?
If you’re against this vaccine which isn’t mRNA and you’re against mRNA, then you must be an anti-vaxxer.
Fool me once...
Fool me twice...
Fool me three times...
Fool me four times...
Fool me five times...
Fool me six times...
...
Make a spray to "stop it" before it makes headway.
Test it on the families of Congress, CDC, etc.
This sounds like a viable and safer alternative to the mRNA clot shot. But since I’ve already had covid, I won’t be getting it.
so these are not MNRA vaccines?
Yes they are, just in nasal spray form................
What’s “Covid-19”?
This approach is very much more traditional than the gene therapy mRNA approach, which is not a vaccine.
I’m not advocating this vaccine, just informing.
A nasal vaccine has already been around for the flu for a number of years—although not nearly as long as the traditional flu shots. If this one is like that then its the first actual vaccine (as opposed to the jabs which are just an experimental gene therapy platform).
One of the treatment and prevention regimens of the Front Line Covid Critical Care Doctors was not only Vitamins D,C, Zinc, Ivermectin, and Betadine an iodine based Nasal spray you can get OTC.
Basically, spray it in your nose after being in crowded places and it kills the covid virus plus they make a gargle version of the same product.
Of course, it’s cheap and effective so it will never get recommended.
> Isn’t this exactly what some have been calling for, a ‘real’ vaccine which isn’t mRNA based. <
Yes, that seems to be the case here. If so, this is very good news.
However, the medical community has damaged its credibility over the last three years. Like many others, I no longer trust everything they say. So I won’t be first in line for this new spray. But maybe later.
that is not what I am reading here. that these are live viruses
My wife is a retired biologist, she worked on this approach some years back when it was first used on influenza under the brand name “Flumist”. It was more expensive to produce for dose than traditional vaccine shots and never seemed to really catch on.
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