Posted on 11/10/2019 3:06:54 AM PST by tired&retired
For the first time, a study shows how glucocorticoid hormones, such as cortisol, control sugar and fat levels differently during day and night, feeding and fasting, rest and activity, over the course of 24 hours.
The research conducted in mice found that the time-of-day dependent metabolic cycle is altered by high caloric diet. Since glucocorticoids are widely used drugs for the treatment of inflammatory diseases, these findings published in Molecular Cell suggest that lean and obese patients might respond differently to steroid therapy. Finally, it reveals the biological function of daily rhythms of hormone secretion (high before awakening and feeding, low when sleeping and fasting) as well as daily cycles of sugar and fat storage or release by the liver.
Each cell in the human body is driven by an internal clock which follows the circadian rhythm of 24 hours. It is synchronized with the natural cycle of day and night mainly by sunlight, but also through social habits. In a healthy system, glucocorticoid stress hormones, are produced every morning by the adrenal gland.
The secretion of glucocorticoidpeaks before awakening, prompting the body to use fatty acids and sugar as sources of energy, and enabling us to start our daily activities. When the circadian rhythm is disrupted (e.g. through shift work or jetlag) and/or when the glucocorticoid level alters (e.g. through Cushing syndrome or long-term clinical application), profound metabolic dysregulation can be caused -- like obesity, type 2 diabetes, and fatty liver disease. The researcher's goal therefore was to understand the relevance of these daily peaks of stress hormone secretion, the impact of these hormones on our "internal clock" and their role for daily cycles of metabolism.
(Excerpt) Read more at sciencedaily.com ...
Why waste time on mice? This kind of research can be done on humans. In the KETO community there is amazing research going on with volunteers. Google, Dave Feldman
Thanks for sharing. My experience is similar. I fast once a week. Last meal is Sun. dinner until Tues. breakfast. I feel great and once I got used to it, it’s not so hard.
I went KETO in Feb. and have lost 25 pounds. 195 to 170. ;o)
That’s AWESOME.
I LIKE that time frame. Sun. evening till tues breakfast.
More realistic and doable.
3 days was brutal.
Keep it up!
Sounds about right by what I’ve read and experienced.
18:6 Intermittent Fasting is a breeze, especially on Keto, because you don’t get hungry.
It’s basically an early dinner, no breakfast, and a late lunch.
Jillian Michaels is the main Keto Pooper, then you realize most of the people on her insipid show have gained all the weight back, and then some.
Well, we know why. They want everyone living on rice and beans.
https://www.vox.com/the-highlight/2019/7/25/18744359/keto-diet-weight-loss-diabetes
This article is a non-scientific overview both pros & cons.
Here is a pull quote:
“...the work is nothing short of revolutionary. “A guy named Thomas Kuhn pointed out that scientific revolutions don’t happen overnight, they happen over time,” he says. “We’re using a non-pharmaceutical, very powerful tool to hopefully halt and turn back an epidemic that is threatening our ability to provide health care because it’s such a dramatically expensive disease.”
By 3:00 AM, the carbs are digested. that event causes disruption resulting in awakening.
If you lose weight that fast, wouldn’t you have to worry about sagging skin?
I generally lose about a pound a week, which is exactly what I want, because it should avoid issues with sagging skin.
About 2 years ago I did and extensive Pub Med journal article review on the “Neuroscience of Fasting and Starvation.”
I primarily did it to understand the spiritual aspects of fasting. The result, I still need to test in the lab, but basically the ketone process provides a better fuel source for the brain allowing or facilitating the action potential firing rate to reach the gamma frequencies necessary for the mystical experience.
Perception of reality changes with brain wave frequency.
LOL, it’s having to take a massive pee that wakes me up.
I like Dr. Berg and Dr. Ken Berry’s videos.
“Well, we know why. They want everyone living on rice and beans.”
Yep, there’s really no practical way to blend Keto (super-low carb), with not eating meat. It’s possible in theory (I’ve seen write-ups on it), to some extent, but very risky regarding the nutrients you may miss. You wind up having to pretty much eat nuts and avocados for most nutrients, and the quantity of that is quite limited because they do have carbs.
By far the easiest option is to put off saving the planet for a bit, and pretty much replace carbs with fat, ideally coming from red meat.
please add me to your Low-Carb ping list ... thanks ...
You really don’t need eat a lot of meat, though. Basically a cut of meat the size of a deck of cards will do, although I usually do go beyond that.
I eat a lot more vegetables than ever since I’ve gone Keto.
I wake up at 3 am no matter what. Even when I go to bed at midnight.
This week I am in San Diego which is rough as my East Coast 3 am is now waking me up for meditation at midnight.
It would never pass the review board to be done.
“allowing or facilitating the action potential firing rate to reach the gamma frequencies necessary for the mystical experience.
Perception of reality changes with brain wave frequency.”
____
Also interesting, thanks.
“If you lose weight that fast, wouldn’t you have to worry about sagging skin?”
I’ve read that Keto wont give you sagging skin, but then again, that may be hype, or it may depend on genetics, per this thread on Reddit.
https://www.reddit.com/r/keto/comments/5khwg1/question_keto_intermittent_fasting_and_saggy_skin/
I guess one option is to lose the weight and find out...and if the saggy skin is too bothersome, perhaps add a bit of weight back, or have it cut off.
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