Posted on 09/16/2024 4:38:41 AM PDT by Red Badger
In a phase 1 trial, the oral drug Amycretin helped individuals lose up to 13.1% of their body weight in three months by targeting key appetite-regulating hormones, presenting a potential breakthrough in tablet-form obesity treatments.
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Amycretin, an oral weight loss drug, led to up to 13% body weight reduction in three months, showing potential for continued weight loss. While well-tolerated, further long-term studies are needed to evaluate its safety and efficacy.
Individuals who received a once-a-day oral weight loss drug had lost up to 13% of their body weight over three months, according to a recent presentation at the annual meeting of the European Association for the Study of Diabetes (EASD) in Madrid, Spain (9-13 September).
Amycretin, which is being developed by the Danish pharmaceutical company Novo Nordisk A/S, mimics the action of two peptide hormones in one single molecule.
Amycretin is both an amylin and glucagon-like peptide-1 (GLP-1) receptor agonist. Both of these play a key role in appetite regulation and feelings of hunger and have been shown to lead to weight loss.
Current Treatments and Study Design
Currently, GLP-1 based treatment options are mainly administered via injections, a delivery method also used for the amylin-based treatments undergoing clinical development. To date, there are no tablet-form treatment options targeting both of these biologies.
In a single-center, placebo-controlled, double-blinded phase 1 study, adult participants with a BMI of 25.0-39.9 kg/m2 without diabetes were randomized to receive amycretin or a placebo once-a-day for up to 12 weeks.
The study, which was conducted by Novo Nordisk A/S, and a clinical research unit in the US, consisted of single- and multiple ascending dose parts, where different doses of amycretin were tested orally: single-ascending dose (increasing from 1 mg a day to 25 mg)10-day multiple-ascending doses (investigating from 3 to 12 mg), and 12-week multiple-ascending doses (by introducing stepwise dose escalation, investigating from a start dose of 3 mg and up to a final dose of 2×50 mg).
In the first-in-human trial, amycretin appeared to have a safe and tolerable profile in line with the drug receptor classes. Side effects were mainly mild to moderate in severity and of gastrointestinal nature including nausea and vomiting.
Weight Loss Results
At the end of the trial, average weight loss was greater with amycretin than with the placebo. Participants taking amycretin 50 mg reduced their body weight by 10.4%, on average, within 12 weeks of treatment, while those taking amycretin 2x50mg, the maximum dose tested, achieved a body weight reduction of 13.1%. This compares to an average weight loss of 1.1% among those taking placebo during the same time.
Notably, at the end of the treatment period, weight loss had not reached a plateau for participants taking amycretin, indicating the potential for further weight loss with extended use.
The study’s authors conclude that daily oral amycretin treatment in adults with overweight or obesity and without diabetes demonstrated a safe and tolerable profile in line with the drug receptor classes, and with notable reductions in body weight.
They add: “A single molecule that targets both amylin and GLP-1 biology in a tablet form could offer a more convenient approach to achieving better outcomes for individuals with overweight or obesity.
“However, larger and longer studies are needed to fully assess the drug’s safety profile and potential.”
Meeting:
Annual Meeting of the European Association for the Study of Diabetes (EASD)
Plastic surgery to remove the excess sags can be very effective.
[Amycretin]
Pronounced “I’m a cretin”?
So, what was this serious but non-fatal adverse effect?
"In the first-in-human trial, amycretin appeared to have a safe and tolerable profile in line with the drug receptor classes. Side effects were mainly mild to moderate in severity and of gastrointestinal nature including nausea and vomiting."
Well, some have said that any weight loss resulting from use of daily apple cider vinegar is the result of the nausea from drinking vinegar. (Some British Medical Journal state this a few years ago, probably in support of modern pharma industry.) A more recent study in Lebanon indicates:
Drinking 1 Tablespoon of Apple Cider Vinegar Each Day Linked to Weight Loss in Younger Adults
The authors of the article circle back to the "nausea for weight loss" theory.
The Romans used vinegar--probably wine vinegar--as an energy drink so there is probably something to it. (Someone said Di-acetic acid is a Ketone?)
I lost thirty pounds in about three months just from consuming two or three homemade fruit smoothies mixed with a protein powder.
I am not going to pretend it’s the healthiest way to lose weight, but I feel much better. I weigh less than I did forty years ago when I was in basic training.
Vinegar, dilute acetic acid, of 5% is safe for human consumption.
Acetic acid of 20%+ concentration is poison.............
I know how to fast. But I still eat too much. I eat past when I’m full. How did you learn to stop eating when you are full . I’m 71. These I just feel terrible when I eat because I eat too much. I’m not eating sugars or carbs either . I’m eating the right stuff. Just too much of it .
I know how to fast. But I still eat too much. I eat past when I’m full. How did you learn to stop eating when you are full . I’m 71. These I just feel terrible when I eat because I eat too much. I’m not eating sugars or carbs either . I’m eating the right stuff. Just too much of it .
Like the cousins, the outward side effect is that you crap like a goose. One of the reasons for the uncontrollable potty problems on airplanes. Who can say what else is brewing in the body because of it?
"In the first-in-human trial, amycretin appeared to have a safe and tolerable profile in line with the drug receptor classes. Side effects were mainly mild to moderate in severity and of gastrointestinal nature including nausea and vomiting."
Well, some have said that any weight loss resulting from use of daily apple cider vinegar is the result of the nausea from drinking vinegar. (Some British Medical Journal state this a few years ago, probably in support of modern pharma industry.) A more recent study in Lebanon indicates:
Drinking 1 Tablespoon of Apple Cider Vinegar Each Day Linked to Weight Loss in Younger Adults
The authors of the article circle back to the "nausea for weight loss" theory.
The Romans used vinegar--probably wine vinegar--as an energy drink so there is probably something to it. (Someone said Di-acetic acid is a Ketone?)
No, it's an acid. The carbonyl group (carbon double-bonded to oxygen, CO) has a hydroxy group (oxygen single-bonded to hydrogen, OH) on one side, which makes it an acid. The combined group (COOH) is called a carboxyl group.
A ketone has the carbonyl group with aliphatic carbon groups (like methyl, ethyl, propyl, butyl) on either side of it.
I worked with a lady who was morbidly obese who lost a lot a weight through surgery. She had the excess skin removed via surgery. Unfortunately she still ended up passing away. She had been to heavy for too long.
Thread diversion and Chemistry for fun and education! Acetic acid at concentrations of 99% or higher it freezes at about 60 degrees. (Ethanoic acid.) And yes, can be dangerous. (As you already know!)
Click and go to place on video showing picture of "frozen" ethanoic acid (left bottle.)
https://patientsafetyj.com/article/116280-what-to-know-about-glacial-acetic-acid-stop-using-it
Multiple events involving patient harm from the use of undiluted glacial acetic acid have been reported to the Pennsylvania Patient Safety Reporting System (PA-PSRS). Glacial acetic acid is anhydrous pure acetic acid available in concentrations between 99.5% and 100%.1–4 Unlike acetic acid solutions which have various medical uses when diluted to different concentrations (e.g., 0.25% for irrigation, 2% for otic use), glacial acetic acid is highly corrosive; has no medical purpose; and has been associated with serious patient harm, such as severe tissue damage and third-degree burns.1–4
and also:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589881/
Why don’t you just do what the rest of us do to stop eating too much?: put your fork down and walk away from the food. Finish what’s on your plate and go.
Publius; Thank you! Appreciate the correction and the information!
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