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Key Points Eli Lilly said its next-generation drug cleared a crucial late-stage trial in patients with obesity, delivering significant weight loss across doses. The results bring Lilly one step closer to filing for approval of the weekly injection, called retatrutide, which works differently from existing injections and pills. The highest dose of retatrutide helped patients lose 28.3% of their weight — or 70.3 pounds — on average over 80 weeks. ==================================================================== VIDEO AT LINK........ Eli Lilly on Thursday said its next-generation drug cleared a crucial late-stage trial in patients with obesity, delivering significant weight loss across doses. The results bring...

After decades of stigma, researchers are studying cannabis and its compounds like never before. As regulations and restrictions ease in many parts of the world, including the US, this controversial plant and its ancient health claims are finally being put to the test. For many years now, scientists have noticed that some cannabis users tend to have lower body weight and a reduced risk of developing type 2 diabetes compared to those who don't use cannabis. That is somewhat unexpected, as cannabis is known to trigger the 'munchies', or an appetite for food, in those who use the drug. Now,...

AbstractDietary interventions are the first-line treatment for overweight individuals (OW) and individuals with obesity (OB) who have high-normal blood pressure (BP) or grade I hypertension, particularly when they are at low-to-moderate cardiovascular risk (CVR). However, current guidelines do not specify the most effective dietary approach for optimising cardiovascular and metabolic outcomes in this population.This study aimed to compare the effects of a low-calorie, high-protein ketogenic diet (KD) versus a low-calorie, low-sodium, and high-potassium Mediterranean diet (MD) on BP profiles assessed via ambulatory BP monitoring (ABPM). It also evaluated changes in anthropometric measures, metabolic biomarkers, and body composition measured by bioelectrical...

New York University Abu Dhabi creates oral LED alternative designed to regulate appetiteAn enterprising team of scientists in Abu Dhabi have harnessed cutting-edge technology in a long-term quest to provide patients with a "holy grail" alternative to hugely popular weight-loss drugs. The researchers from New York University Abu Dhabi (NYUAD) have developed a tiny ingestible device that emits light and, in doing so, could stimulate nerve cells or neurons in the gut, potentially altering which nutrients are absorbed or affecting whether a person feels hungry. Dr Khalil Ramadi, an assistant professor of bioengineering at NYUAD, who heads the team...

(DCNF)—President Donald Trump announced Thursday that the price of Ozempic will fall from more than $1,000 to $199, a dramatic reduction for one of the most expensive and widely used prescription drugs in the country. Pharmacy “cash price” for a single Ozempic pen can exceed $1,300 at some U.S. outlets, according to pricing data. During the launch of Trump RX, Trump said manufacturers agreed to slash prices for popular GLP-1 weight-loss medications, insulin, asthma inhalers, and fertility drugs after sustained pressure from his administration.

Charity Pierce, who appeared on the TLC show My 600-lb Life, has died at age 50 after reportedly suffering from various health ailments. Pierce passed away with loved ones by her side at 1:20AM on Tuesday, a family source told TMZ. The source said various medical conditions had resulted in Pierce being placed in hospice care for the past month or two. symbol 00:55 02:24 Read More The health issues included lymphedema and fluid buildup in her lungs, with the source saying the fluid was a possible factor in her death. A cause of death is not yet known. Pierce,...

Soybean oil appears to cause obesity in mice by producing oxylipins that alter liver metabolism and fat processing. Only mice with altered enzymes avoided weight gain, suggesting genetics and modern diets play a major role. Credit: Shutterstock Soybean oil is the most commonly used cooking oil in the United States and appears in a wide range of processed foods. Research is now shedding light on how this highly consumed ingredient contributes to obesity in mice. In a University of California, Riverside experiment, most mice fed a high-fat diet rich in soybean oil put on substantial weight. A separate group of...

Lizzo believes we, as a society, must “undo the effects of the Ozempic boom” because plus-sized women are being “erased.” The musician, 37, took to Substack on Sunday to share an essay titled, “Why is everybody losing weight and what do we do? Sincerely, a person who’s lost weight.” Lizzo, who began shedding pounds in the fall of 2023 following a very public harassment and hostile work environment scandal, confessed that the ordeal made her “deeply suicidal.” (snip) “We’re in an era where the bigger girls are getting smaller because they’re tired of being judged. And now those bigger girls...

It's not pleasant to shiver from the cold, but for some, it has the appeal of making the body burn more energy as heat than when staying in a warmer environment. This process of burning energy through heat loss is called thermogenesis. While scientists and pharmaceutical companies are exploring ways to trick the body into thinking it's cold, obesity researchers set out to investigate another route: a form of thermogenesis triggered by eating specialized diets rather than temperature. After conducting a series of mouse studies, the researchers concluded that diet-induced thermogenesis led to nearly the same amount of weight loss...

A little-known microbe in your gut produces methane and may help your body extract more calories from food, according to a study led by Arizona State University. Deep inside your gut lives a vast community of microbes, and among them is one unusual resident that produces methane. This lesser-known methane-producing microbe may influence how efficiently your body absorbs calories from food, according to new research from Arizona State University. This community of microbes is collectively known as the microbiome. In some people, the gut microbiome generates large amounts of methane, while in others it produces very little. Researchers discovered that...

A new analysis of two large clinical trials reveals that a higher weekly dose of semaglutide (7.2 mg) can drive significantly greater weight loss and metabolic improvements in adults with obesity, including those with type 2 diabetes. Credit: Shutterstock =========================================================================== High-dose semaglutide drives greater weight loss. Safety remains favorable but needs further study. A weekly semaglutide dose of 7.2 mg has been shown to markedly enhance weight loss and improve health outcomes for adults with obesity, including those who also have type 2 diabetes (T2D). Evidence from two large, international phase 3 clinical trials, published in The Lancet Diabetes &...

Key Points Novo Nordisk said it now offers cash-paying U.S. patients its blockbuster diabetes treatment Ozempic for less than half its monthly list price through multiple platforms. Patients can pay $499 in cash per month for three dose sizes of Ozempic through the drug’s official website, Novo Nordisk’s patient assistance program, the company’s recently launched direct-to-consumer online pharmacy and drug savings company GoodRx, among other platforms. It comes after Trump in July sent separate letters to Novo Nordisk and 16 other drugmakers, calling on them to take steps to lower medication prices in the U.S.

Women and older adults taking the anti-obesity drug semaglutide may be at higher risk for muscle loss, but higher protein intake may help prevent muscle loss in these patients, according to a small study. Losing muscle (or lean mass) is a common side effect of weight loss in adults with obesity and may negatively affect metabolism and bone health. This is because muscle helps control blood sugar after meals and plays an important role in keeping bones strong, according to Melanie Haines, M.D. Approximately 40% of weight lost from taking semaglutide—a type of weight-loss medication known as a GLP-1—comes from...

Scientists have produced the first detailed characterization of the changes that weight loss causes in human fat tissue by analyzing hundreds of thousands of cells. They found a range of positive effects, including clearing out of damaged, aging cells, and increased metabolism of harmful fats. The study compared samples of fat tissue from healthy weight individuals with samples from people with severe obesity (BMI over 35) undergoing bariatric weight loss surgery. The weight loss group had fat samples taken during surgery and more than five months after surgery, at which point they had lost an average of 25 kg. The...

@MJTruthUltra He looks like a skeleton now… what happened to a Mike Pompeo?

A major new study reveals that combining the weight-loss drug tirzepatide with menopause hormone therapy leads to significantly greater fat loss in postmenopausal women. Women using both therapies saw an average weight loss of 17%—compared to just 14% with tirzepatide alone—and were more than twice as likely to lose 20% or more of their body weight. Tirzepatide Plus Hormone Therapy Boosts Weight Loss in Postmenopausal Women Using tirzepatide and menopause hormone therapy at the same time leads to increased weight loss in postmenopausal women with overweight or obesity compared to use of tirzepatide treatment alone, according to a study being...

Cancer deaths linked to obesity more than tripled in the U.S. during the past two decades, a new study says. Deaths linked to the 13 types of obesity-related cancer rose to 13.5 deaths per million from 3.7 deaths per million between 1999 and 2020, researchers reported Sunday at the Endocrine Society’s annual meeting in San Francisco. “Obesity is a significant risk factor for multiple cancers, contributing to significant mortality,” said lead researcher Dr. Faizan Ahmed of Hackensack Meridian Jersey Shore University Medical Center in Neptune City, N.J.

A new drug prevents weight gain and fatty liver by controlling magnesium in cells. It made mice stay slim despite lifelong exposure to an unhealthy diet. Credit: Stock Scientists have unveiled a small-molecule drug that blocks weight gain and liver damage in mice forced to live on sugary, high-fat food. The compound works by limiting magnesium inside mitochondria—the cell’s power plants—so energy keeps burning instead of stalling. Treated mice quickly slim down and show no signs of fatty-liver disease, hinting at a future therapy against obesity, heart trouble, and cancer tied to poor diets. Breakthrough Drug Fights Fat and Liver...

Halofuginone shows promise for weight loss by boosting key metabolic regulators. Overweight and obesity have quickly become major global health challenges, increasing the risk for a wide range of serious diseases. As people around the world strive for healthier lifestyles, the demand for effective weight loss solutions is growing stronger than ever. Halofuginone (HF), a natural compound extracted from the roots and leaves of the Changshan plant, could emerge as a powerful new option for tackling obesity. For more than 2,000 years, Changshan, the root of Dichroa febrifuga Lour, has been used in traditional Chinese medicine to treat fever caused...

New research suggests that lycopene, which gives fruits like tomatoes and watermelons their bright red color, supports healthy liver functioning and may help prevent weight gain. Lycopene is an antioxidant, anti-inflammatory compound that is naturally produced by some plants. It is also available as a dietary supplement. The researchers' interest in studying the impacts of tomato consumption and lycopene on obesity was sparked by a previous study that showed dietary estrogen supplements prevented zebrafish from becoming obese despite being overfed. Since lycopene and other compounds found in tomatoes affect some of the same chemical pathways as estrogen, the scientists wondered...