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Posted on 05/29/2024 12:49:48 PM PDT by Red Badger
The world's first human trial of a drug that can regenerate teeth will begin in a few months, less than a year on from news of its success in animals. This paves the way for the medicine to be commercially available as early as 2030.
The trial, which will take place at Kyoto University Hospital from September to August 2025, will treat 30 males aged 30-64 who are missing at least one molar. The intravenous treatment will be tested for its efficacy on human dentition, after it successfully grew new teeth in ferret and mouse models with no significant side effects.
"We want to do something to help those who are suffering from tooth loss or absence," said lead researcher Katsu Takahashi, head of dentistry and oral surgery at Kitano Hospital. "While there has been no treatment to date providing a permanent cure, we feel that people's expectations for tooth growth are high."
Following this 11-month first stage, the researchers will then trial the drug on patients aged 2-7 who are missing at least four teeth due to congenital tooth deficiency, which is estimated to affect 1% of people. The team is recruiting for this Phase IIa trial now.
Researchers are then looking at expanding the trial to those with partial edentulism, or people missing one to five permanent teeth due to environmental factors. The incidence of this varies from country to country, but it's estimated around 5% of Americans are missing teeth, with a much higher incidence among older adults.
The medicine itself deactivates the uterine sensitization-associated gene-1 (USAG-1) protein, which suppresses tooth growth. As we reported in 2023, blocking USAG-1's interaction with other proteins encourages bone morphogenetic protein (BMP) signaling, which triggers new bone to generate.
(Excerpt) Read more at newatlas.com ...
The medicine will grow teeth.
The problem is they look like rodents teeth!😜
Eat honey too
Not if Big Poligrip has anything to say about it.
Rejoice, ye who identify as unicorns!
You don’t expect anyone to actually click on the link? /S
I thought about it but don’t want to get Rick rolled!
This runs in my family. Not a complete third set that I know of, but lots more than the second set ought to be. And it's no fun.
Now that’s scary.
Good thinking.
James Carville’s twin.
I think the “medicine” is an antibody to USAG-1 system. Not RNA yet...but someone is gonna’ try to get mRNA to block USAG-1 system...I hope mRNA gene therapy goes the way of past practice of using radioactive Uranium to treat rheumatoid arthritis or fluoroscopes in shoe stores.
I would guess there are other parts of our body that utilize the same biochemical system that they want to inhibit....
They already made that movie:
/s
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