Free Republic
Browse · Search
General/Chat
Topics · Post Article

Skip to comments.

Team discovers surprise contributor to multiple sclerosis
medicalxpress.com ^ | October 7, 2019 | University of Virginia

Posted on 10/08/2019 8:18:25 AM PDT by BenLurkin

Cells that scientists have largely ignored when studying multiple sclerosis are actually key contributors to MS development, new research from the University of Virginia School of Medicine shows. The discovery suggests new avenues for devising treatments and is a vital step toward finding a cure.

Cells that scientists have largely ignored when studying multiple sclerosis are actually key contributors to MS development, new research from the University of Virginia School of Medicine shows. The discovery suggests new avenues for devising treatments and is a vital step toward finding a cure.

In MS, the body's immune system begins to attack the myelin, leading to a progressively disabling neurological condition that affects more than 2 million people worldwide. (MS is the most common neurological condition among the young, and is often diagnosed between ages 20 and 50.)

It has been thought that these progenitors do not efficiently give rise to myelin-producing cells in people with MS. Yet, UVA's Alban Gaultier, Ph.D., and his team made the surprising discovery that they are also actively participating in the immune system's harmful attacks on myelin.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: animalresearch; autoimmunedisease; genetics; health; ms; multiplesclerosis; universityofvirginia; uva; virginia
Navigation: use the links below to view more comments.
first 1-2021-25 next last

1 posted on 10/08/2019 8:18:25 AM PDT by BenLurkin
[ Post Reply | Private Reply | View Replies]

To: BenLurkin

Interesting. My dad was diagnosed with MS in his late 40s with no prior indications. After it progressed rapidly at first it stablized and has seen no major advance for 20 years.

They still have not figured out what initiates it. Though there has been conjecture on pockets of MS - genetic and geographic, they haven’t been able to pinpoint anything definitively. (unless I’ve missed research I’m unaware of).

My dads history and this research to me indicates that there is something causing the attack on the myelin to switch on and then when the initiator is dormant or gone it turns off the attack.


2 posted on 10/08/2019 8:34:02 AM PDT by reed13k (For evil to triumph it is only necessary that good men do nothing)
[ Post Reply | Private Reply | To 1 | View Replies]

To: BenLurkin

Great news for MS sufferers, including Mrs. LS.


3 posted on 10/08/2019 8:34:50 AM PDT by LS ("Castles made of sand, fall in the sea . . . eventually" (Hendrix))
[ Post Reply | Private Reply | To 1 | View Replies]

To: BenLurkin

My father-in-law was diagnosed in his 80s. The doctors didn’t seem sure that’s what he had or maybe we didn’t understand the diagnosis, but it was really late in life to develop that illness, we thought. He would have a flare, and then get better, but never quite as well as he was before each flare.


4 posted on 10/08/2019 8:39:16 AM PDT by Tuscaloosa Goldfinch
[ Post Reply | Private Reply | To 1 | View Replies]

To: BenLurkin

What a terrible disease.


5 posted on 10/08/2019 8:46:55 AM PDT by ImJustAnotherOkie (All I know is The I read in the papers.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: ImJustAnotherOkie

My brother in law is in hospice care right now, in the final stage of this horrendous disease. It’s taken everything from him. Completely paralyzed, bedridden, and unable to do anything but blink his eyes. His body is has been completely savaged by thus disease. This was a perfectly healthy man. A health nut who actually enjoyed exercise and healthy foods. He neither smoked, drank nor took drugs, EVER, he was so health conscious.
Yet here he is.
But let me share one more thing. He never wavered from his faith in the finished work of Christ for himself. He is an inspiration to all who know him. He is a hero. And I know that one day very soon he will hear “well done, they good and faithful servant”. I love you Harlan


6 posted on 10/08/2019 9:00:54 AM PDT by smvoice (I WILL NOT WEAR THE RIBBON. I'M AN ANTI DEMITE. forked tongue.)
[ Post Reply | Private Reply | To 5 | View Replies]

To: BenLurkin
...and is a vital step toward finding a cure.

I cal BS. We don't cure diseases anymore. There's too much $$ in treating things.

7 posted on 10/08/2019 9:03:52 AM PDT by ConservaTexan (February 6, 1911/June 14, 1946)
[ Post Reply | Private Reply | To 1 | View Replies]

To: BenLurkin

Wonder if the American Love affair with statins and low fat diets are possible factors here?:

In a recently published article in Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease, Isobel A. Scarisbrick, Ph.D., director of the Neuroregeneration and Neurorehabilitation Laboratory at Mayo Clinic’s campus in Rochester, Minnesota, and co-authors investigate the relationship between fat intake, exercise and myelin production in mice.

The roles that dietary fat intake and other external factors play in the production of oligodendrocytes and OPCs is not well-understood.

Although brain lipids have high fat content, consumption of a diet containing excess fats and sugars has been shown to be detrimental to CNS function. However, myelin assembly requires a significant amount of lipids, and lipids play an important role in glial cell myelination.


8 posted on 10/08/2019 9:04:08 AM PDT by Grampa Dave (The line that separated satire, Democrats and Stupidity has vanished. (thanks to jonascord)!)
[ Post Reply | Private Reply | To 1 | View Replies]

To: reed13k

I had a friend who ran marathons. She had gotten MS when she was a young mother with 4 little ones under the age of 5. Husband was working in Fairbanks and they could never go outside, etc. She was absolutely sure/ and working on a PhD to put her theory into print/ that she had ‘given up’ with all the stress and her body had responded with MS.

She had gone to those faith healer/ Catholic/ witch doctors in the Phillipines - on a stretcher - and been healed.

(She died in an auto accident/ research not published).


9 posted on 10/08/2019 9:10:34 AM PDT by bboop (does not suffer fools gladly)
[ Post Reply | Private Reply | To 2 | View Replies]

To: smvoice

Prayers for Harlan and your family, what an inspiration to all.


10 posted on 10/08/2019 9:14:25 AM PDT by pbear8 (the Lord is my light and my salvation)
[ Post Reply | Private Reply | To 6 | View Replies]

To: smvoice

Thank you for this touching post.


11 posted on 10/08/2019 9:43:41 AM PDT by NEMDF
[ Post Reply | Private Reply | To 6 | View Replies]

To: Grampa Dave

Is the Ketogenic diet good for multiple sclerosis?

https://www.medicalnewstoday.com/articles/323895.php#targetText=The%20ketogenic%20diet%20is%20low,for%20everyone%20with%20multiple%20sclerosis.&targetText=The%20ketogenic%20diet%20does%20offer,factors%20before%20trying%20the%20diet.


12 posted on 10/08/2019 9:48:03 AM PDT by dfwgator (Endut! Hoch Hech!)
[ Post Reply | Private Reply | To 8 | View Replies]

To: BenLurkin

Multiple sclerosis will prove to be another disease caused by a particular combination of factors .....a leaky intestinal wall and a porous vagus nerve deliver negative-mimicking bacteria combined with food antigens into the brain’s fourth ventricle. Food antigens cling to nerve myelin, and the immine system creates antibodies to attack them. The bacteria evolve to create negative impressions of the food antigens. The immune system creates antibodies to attack the bacteria. The immune system also attacks myelin because its protein signature is identical to the bacteria’s protein signature.

Incidently, the bacteria and the leaky gut are both caused by ingestion of carbohydrates. Ingesting fat instead goes a long way toward eliminating the problem.


13 posted on 10/08/2019 10:14:59 AM PDT by nagant
[ Post Reply | Private Reply | To 1 | View Replies]

To: BenLurkin
Here is a potential cure:
Metformin 'can reverse nerve damage caused by MS in rats in three months
14 posted on 10/08/2019 10:19:25 AM PDT by aimhigh (THIS is His commandment . . . . 1 John 3:23)
[ Post Reply | Private Reply | To 1 | View Replies]

To: dfwgator

Wow! Thanks for this link!

Is the Ketogenic diet good for multiple sclerosis?

https://www.medicalnewstoday.com/articles/323895.php#targetText=The%20ketogenic%20diet%20is%20low,for%20everyone%20with%20multiple%20sclerosis.&targetText=The%20ketogenic%20diet%20does%20offer,factors%20before%20trying%20the%20diet.


15 posted on 10/08/2019 10:23:35 AM PDT by Grampa Dave (The line that separated satire, Democrats and Stupidity has vanished. (thanks to jonascord)!)
[ Post Reply | Private Reply | To 12 | View Replies]

To: nagant; dfwgator

“Incidently, the bacteria and the leaky gut are both caused by ingestion of carbohydrates. Ingesting fat instead goes a long way toward eliminating the problem.”


16 posted on 10/08/2019 10:27:49 AM PDT by Grampa Dave (The line that separated satire, Democrats and Stupidity has vanished. (thanks to jonascord)!)
[ Post Reply | Private Reply | To 13 | View Replies]

To: LS

I’m sorry to hear that. My FIL has it. Late stages now.


17 posted on 10/08/2019 10:28:23 AM PDT by RinaseaofDs
[ Post Reply | Private Reply | To 3 | View Replies]

To: Grampa Dave
Although brain lipids have high fat content, consumption of a diet containing excess fats and sugars has been shown to be detrimental ...

I'd look at the excess sugars as the problem before the fat. But that's just me.

18 posted on 10/08/2019 10:57:36 AM PDT by pepsi_junkie (Often wrong, but never in doubt!)
[ Post Reply | Private Reply | To 8 | View Replies]

To: pepsi_junkie

This factor should be included in the discussion

However, myelin assembly requires a significant amount of lipids, and lipids play an important role in glial cell myelination.

My wife spent over 3 decades in a busy FP practice as the head RN, and your theory/notation of excess sugars was something she said was an early warning of hidden/impending bad health.

Re the teen/young adult diabetes and the early Adult onset of diabetes.

She has a problem not lecturing the X-large size teens and young adults buying bottles of sugar laced drinks and candy bars outside of stores for lunch or whatever.


19 posted on 10/08/2019 11:16:30 AM PDT by Grampa Dave (The line that separated satire, Democrats and Stupidity has vanished. (thanks to jonascord)!)
[ Post Reply | Private Reply | To 18 | View Replies]

To: LS; aimhigh

LS fyi:

Metformin ‘can reverse nerve damage caused by MS in rats in three months


20 posted on 10/08/2019 11:18:29 AM PDT by Grampa Dave (The line that separated satire, Democrats and Stupidity has vanished. (thanks to jonascord)!)
[ Post Reply | Private Reply | To 14 | View Replies]


Navigation: use the links below to view more comments.
first 1-2021-25 next last

Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.

Free Republic
Browse · Search
General/Chat
Topics · Post Article

FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson