Posted on 08/07/2017 6:28:56 PM PDT by buckalfa
Researchers at The Ohio State University Wexner Medical Center and Ohio State's College of Engineering have developed a new technology, Tissue Nanotransfection (TNT), that can generate any cell type of interest for treatment within the patient's own body. This technology may be used to repair injured tissue or restore function of aging tissue, including organs, blood vessels and nerve cells.
Results of the regenerative medicine study published in the journal Nature Nanotechnology.
"By using our novel nanochip technology, injured or compromised organs can be replaced. We have shown that skin is a fertile land where we can grow the elements of any organ that is declining," said Dr. Chandan Sen, director of Ohio State's Center for Regenerative Medicine & Cell Based Therapies, who co-led the study with L. James Lee, professor of chemical and biomolecular engineering with Ohio State's College of Engineering in collaboration with Ohio State's Nanoscale Science and Engineering Center.
Researchers studied mice and pigs in these experiments. In the study, researchers were able to reprogram skin cells to become vascular cells in badly injured legs that lacked blood flow. Within one week, active blood vessels appeared in the injured leg, and by the second week, the leg was saved. In lab tests, this technology was also shown to reprogram skin cells in the live body into nerve cells that were injected into brain-injured mice to help them recover from stroke.
"This is difficult to imagine, but it is achievable, successfully working about 98 percent of the time. With this technology, we can convert skin cells into elements of any organ with just one touch. This process only takes less than a second and is non-invasive, and then you're off. The chip does not stay with you, and the reprogramming of the cell starts. Our technology keeps the cells in the body under immune surveillance, so immune suppression is not necessary," said Sen, who also is executive director of Ohio State's Comprehensive Wound Center.
TNT technology has two major components: First is a nanotechnology-based chip designed to deliver cargo to adult cells in the live body. Second is the design of specific biological cargo for cell conversion. This cargo, when delivered using the chip, converts an adult cell from one type to another, said first author Daniel Gallego-Perez, an assistant professor of biomedical engineering and general surgery who also was a postdoctoral researcher in both Sen's and Lee's laboratories.
TNT doesn't require any laboratory-based procedures and may be implemented at the point of care. The procedure is also non-invasive. The cargo is delivered by zapping the device with a small electrical charge that's barely felt by the patient.
"The concept is very simple," Lee said. "As a matter of fact, we were even surprised how it worked so well. In my lab, we have ongoing research trying to understand the mechanism and do even better. So, this is the beginning, more to come."
Researchers plan to start clinical trials next year to test this technology in humans, Sen said.
Funding for this research was provided by Leslie and Abigail Wexner, Ohio State's Center for Regenerative Medicine and Cell-Based Therapies and Ohio State's Nanoscale Science and Engineering Center.
Yeah .... ;)
Bookmark
Stem cells, 3d printed organs, now this. Makes one wish they were a lab rat
I’m just glad they didn’t beam up Rosie O’Donnell!!
Thank you and others for your service and sacrifice. Prayers for a more complete healing.
Does this mean we will have George Soros with us forever???!?
Suppose it causes the Zombie Apocalypse?
And.....
Oh, never mind.
Bttt
BUMP
Hmmm...friend of mine is currently waiting for a heart transplant...wonder if this would potentially solve his problem... in future
That would make an awesome velvet painting to hang in the living room.
NO!!!!!!!!
I NEVER SERVED!!!!!!
My sacrifice was falling down a flight of stairs in Manhattan.
Dont want ANYONE to put me with those men who were injured serving our country.
Went to enlist in National Guard after 9/11 but at 5 11, 240, they said come back after you lose so and so pounds.
To my shame, I could not.
Wow! Sounds like something out of science fiction. Hope this is successful.
This is really interesting. Am I the only one whose spidey sense is tingling here? Whether it’s the odd choice of acronym, the almost impossibly good news, or the very vague description, something doesn’t quite look right here. If you Google it, a lot or more-or-less reputable outlets have covered this within the last day, but also some 4-channers are thinking that it is either a hoax or else a wild claim that will be retracted.
Might be a good time to trust but verify.
I know lots of girls specializing in that very thing.
Sorry to have assumed. Still my prayers stand and I commend you for offering to volunteer.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.