Posted on 03/19/2019 5:52:42 PM PDT by little jeremiah
Many FReepers have knowledge to share about improving and maintaining health and would like to share it and learn from others; and others may not know much yet but want to learn. Some of us don't have much money for good insurance or doctors, some want to try other methods besides prescription meds, and some have experience in treating and solving health problems.
More and more "regular" doctors have accepted treatment methods such as the benefits of acupuncture, massage for many conditions, better diet, use of herbs and so on. There are limits, and often side effects, to some standard medical efforts.
My field is Ayurvedic herbalism and related measures, and have a lot of information I can post when I have time. I have seen herbs and sometimes dietary changes help people (including myself) with issues such as rheumatoid arthritis, high BP, gallstones, kidneystones, repeated boils, UTIs, prostate problems, insomnia, allergies, urinary incontinence, and many more. I hope to learn a lot from others with their knowledge and experience.
There are many "old fashioned" home care methods that were in common use a few generations ago that actually work and are cheap, such as castor oil packs, fomentations using alternating hot and cold water, and the like, which are easy to do. I am sure there is a lot of knowledge here on Free Republic that can be shared.
I would like this thread to stay civil without distruption, so my request is that people who think natural health methods are bunkum, make your own thread.
Yes, that’s his whole post about it. I copied.
Thank you. Isn’t the dog kind of fenbendazole cheap? And same as human kind? i saw a site - posted a link some time back, that sells a bag of straight powder, should be the same kind as for humans, I assume.
Thx!!
the dog fenbendazole is cheap
unless you are a 130 pound dog
yes, a person can take dog or horse fenbendazole
I’ve written and recorded my very first song. In two minutes, it tells you everything you need to know about essential oils, and it’s fun. It’s called “There’s An Oil for That”. Check it out:
Apple: https://music.apple.com/us/album/theres-an-oil-for-that-single/1628972634
Spotify: https://open.spotify.com/track/71fqZtlKljTEqEOYExlr9G?si=0eb1b4542cd84bdd
YouTube: https://www.youtube.com/watch?v=XHPbVnhrjq4
Please share with others who might enjoy it.
Also, I have a weekly video podcast, called “Black Swans of Wellness”, that explores wellness tools so powerful that they seem magical. It’s live Saturday’s at 9 am Pacific, but the recordings are available anytime. So far I have episodes on niacin, chemical and food sensitivities, muscle trigger points, and transcranial DC stimulation (electrical stimulation of the brain).
See https://www.facebook.com/groups/blackswansofwellness
The episode on niacin interests me but I don’t and won’t do facebook.
For non-users of Facebook, here are links to the Zoom recordings:
Introduction to Black Swans of Wellness (4/16/2022): https://zoom.us/rec/share/VMhHkIqRLN-F6c5_aadQPwnxMCrobXLqm5xuZpj23GQdJXrPrsg3Bdedv-E-4rs.QgD29Xn3tvHlohyv?startTime=1650127097000
Introduction to Niacin (4/23/2022): https://zoom.us/rec/play/DvNiDhBV8ybXkaWPxYZbMI0p7iPQvqVLFfKYxlVKLpPrLfSRgaWK5pol65_zAQjU-RTszscvUeSj3Q5r.I9HvLtiiNtT_VM-0?autoplay=true&startTime=1650730102000
Chemical, Food, and Environmental Sensitivities (5/7/2022): https://zoom.us/rec/play/DvNiDhBV8ybXkaWPxYZbMI0p7iPQvqVLFfKYxlVKLpPrLfSRgaWK5pol65_zAQjU-RTszscvUeSj3Q5r.I9HvLtiiNtT_VM-0?autoplay=true&startTime=1650730102000
Trigger Points and Chronic Pain (5/14/2022): https://zoom.us/rec/share/2c0b9ACFBfmkhXRSFd_BiGKxfbHVU80WziGtqTi70f_yf77inzfFPkzjYkJtD9uO.KjeBM63pkppneTQs?startTime=1652544427000
Tremoring (5/21/2022): https://zoom.us/rec/share/6Ji0m-UGrcyPn_ihJha_MEWLcJCstqwnERksoiUL8OnUGa8iIo_SBZ_Q3xlKtvtO.2JluBWW-q7Fphrbz?startTime=1653149447000
75 Hard (6/4/2022): https://zoom.us/rec/share/OJoQJ9NI1R6b3Zh08zrPuT8i-KooJbHw9CSh7jVFQEYo1iES8bsQAKL-lJPje15D.2W3zI7-F4r4wUOfd?startTime=1654359660000
Transcranial DC Stimulation — tDCs (6/11/2022): https://zoom.us/rec/share/qfwvaAYRw5wPpQ-99T5kn7GfJSpnUVIIypb-6OrBWeozJoDUClZ2dg4rJ1XQ09GS.v8ZM_uUMXU_E7B9C?startTime=1654963257000
Thank you so much. ☺
9 Benefits of drinking Green Tea listed. Discusses a study about drinking Green Tea.
"In a study of 12 healthy volunteers, those who received a beverage containing 27.5 grams of green tea extract showed increased connectivity between the parietal and frontal cortex of the brain compared to those who drank a non-green tea beverage.32
The increased activity was correlated with improved performance on working memory tasks, and the researchers believe the results suggest green tea may be useful for treating cognitive impairments, including dementia. According to the study authors:33
"Our findings provide first evidence for the putative beneficial effect of green tea on cognitive functioning, in particular, on working memory processing at the neural system level by suggesting changes in short-term plasticity of parieto-frontal brain connections.
Modeling effective connectivity among frontal and parietal brain regions during working memory processing might help to assess the efficacy of green tea for the treatment of cognitive impairments in psychiatric disorders such as dementia.""
Tea Readily Absorbs Pollutants from Soil
It's difficult to find many drawbacks to tea, but there is one potential issue you should be aware of: pollutants. Green tea plants are known to be especially effective at absorbing lead from the soil, which is then taken up into the plants' leaves. Areas with excessive industrial pollution, such as China (where more than 90%36 of the world's green tea is produced), have been found in the past to contain substantial amounts of lead.37
While those studies looked at lead content during the years 1999 to 2001, according to a ConsumerLab.com analysis reported in 2013 and updated in 2015,38 tea from popular packaged brands like Lipton and Bigelow contained up to 2.5 micrograms of lead per serving compared to no measurable amounts in Teavana brand, which gets its tea leaves from Japan.
(Bigelow denies that these measurements are correct, and in fact points out on its website that ConsumerLabs admitted in their report that lead found in the tea leaves was not in the actual liquid portions when they were brewed.39) The takeaway, then, is don't chew on the leaves.
So, while the lead in the tea leaves is not thought to leach very effectively into the tea you end up drinking, if you're consuming Matcha green tea, one of my favorites, it's especially important that it either comes from Japan or is organically grown in China, which has moved toward organic green tea production in the past few years, and in 2020, announced 132 companies in Pu'er City alone, had obtained a total of 186 organic tea certificates, ranking it No. 1 in China for organic tea.40
According to the late fluoride expert Jeff Green, there are reports of people who have developed crippling skeletal fluorosis from drinking high amounts of iced tea alone.42,43 If you live in an area with fluoridated drinking water, as the majority of Americans do, then you could be getting a double dose of fluoride when you drink tea.
Therefore, when selecting tea of any kind, it should preferably be organic (to avoid pesticides) and grown in a pristine environment that ensures that the least amount of fluoride, heavy metals and other toxins from soil and water possible leaches into the tea trees and leaves. A clean growing environment is essential to producing a pure, high-quality tea."
The previous post regarding Green Tea discussed fluoride in Green Tea and Floridated water. This is the link to a Dr. Mercola article about fluoride from the same email as the Green Tea article just posted.
Pinging the list - lots of new information posted above. Scroll up - flouridation, green tea, podcasts by AZLiberty “Blakc Swans of Wellness”, and more.
Lots of us are tense with all the craziness... a few music and meditation videos to help unwind. The first one really works. Best lying down.
Yoga nidra – The ultimate 23min relaxation experience
https://www.youtube.com/watch?v=3k1WDMEZGAs&list=PLFfAP8mGRvDNttQkVsTJva6pKRBBWzwFS&index=1&t=67s
Soothing Meditation Chant
https://www.youtube.com/watch?v=J3nEMlLqDeQ
1 Hour Divine Gregorian Chant Compilation
https://www.youtube.com/watch?v=9KGGts6WXsg
Oops, forgot to ping the list!
Pinging the list - lots of new information posted above. Scroll up - flouridation, green tea, podcasts by AZLiberty “Blakc Swans of Wellness”, and more.
Hat tip to COUNTrecount. Pinging the list to Ivermectin use in cancer info. Freepmail to get on/off this ping list.
https://greatawakening.win/p/140vaI9zdq/ivermectin-cures-cancer/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043740/
“Ivermectin has powerful antitumor effects, including the inhibition of proliferation, metastasis, and angiogenic activity, in a variety of cancer cells. This may be related to the regulation of multiple signaling pathways by ivermectin through PAK1 kinase. On the other hand, ivermectin promotes programmed cancer cell death, including apoptosis, autophagy and pyroptosis. Ivermectin induces apoptosis and autophagy is mutually regulated. Interestingly, ivermectin can also inhibit tumor stem cells and reverse multidrug resistance and exerts the optimal effect when used in combination with other chemotherapy drugs.”
“IVM can inhibit the replication of flavivirus by targeting the NS3 helicase [17]; it also blocks the nuclear transport of viral proteins by acting on α/β-mediated nuclear transport and exerts antiviral activity against the HIV-1 and dengue viruses [18]. Recent studies have also pointed out that it has a promising inhibitory effect on the SARS-CoV-2 virus, which has caused a global outbreak in 2020 [19]. In addition, IVM shows potential for clinical application in asthma [20] and neurological diseases [21]. Recently scientists have discovered that IVM has a strong anticancer effect.”
“After treatment with IVM, the proliferation of multiple breast cancer cell lines including MCF-7, MDA-MB-231 and MCF-10 was significantly reduced.”
“IVM regulates the tumor microenvironment and mediates immunogenic cell death, which may be a new direction for research exploring anticancer mechanisms in the future.”
“Nambara’s study showed that IVM could significantly inhibit the proliferation of gastric cancer cells in vivo and in vitro and that the inhibitory effect of IVM depended on the expression of Yes-associated protein 1(YAP1)[39].”
“In a study that screened Wnt pathway inhibitors, IVM inhibited the proliferation of multiple cancers, including the colorectal cancer cell lines CC14, CC36, DLD1, and Ls174 T, and promoted apoptosis by blocking the Wnt pathway [41].”
“IVM could inhibit the development of hepatocellular carcinoma by blocking YAP1 activity in spontaneous liver cancer Mob1b-/- mice [43].”
“Experiments confirmed that IVM could significantly inhibit the proliferation of five renal cell carcinoma cell lines without affecting the proliferation of normal kidney cells, and its mechanism may be related to the induction of mitochondrial dysfunction [48].”
“In Nappi’s experiment, it was found that IVM could enhance the drug activity of the anti-androgen drug enzalutamide in the prostate cancer cell line LNCaP and reverse the resistance of the prostate cancer cell line PC3 to docetaxel [50]. Interestingly, IVM also restored the sensitivity of the triple-negative breast cancer to the anti-estrogen drug tamoxifen [36], which also implies the potential for IVM to be used in endocrine therapy. Moreover, IVM was also found to have a good inhibitory effect on the prostate cancer cell line DU145 [51].”
“In an experiment designed to screen potential drugs for the treatment of leukemia, IVM preferentially killed leukemia cells at low concentrations without affecting normal hematopoietic cells [51].”
“The majority of cervical cancers are caused by human papillomavirus (HPV) infection [54,55]. IVM has been proven to significantly inhibit the proliferation and migration of HeLa cells and promote apoptosis [56]. After intervention with IVM, the cell cycle of HeLa cells was blocked at the G1/S phase, and the cells showed typical morphological changes related to apoptosis.”
“In a study by Hashimoto, it found that IVM inhibited the proliferation of various ovarian cancer cell lines, and the mechanism was related to the inhibition of PAK1 kinase [58]. In research to screen potential targets for the treatment of ovarian cancer through the use of an shRNA library and a CRISPR/Cas9 library, the oncogene KPNB1 was detected. IVM could block the cell cycle and induce cell apoptosis through a KPNB1-dependent mechanism in ovarian cancer [59].”
“In a study that screened drugs for the treatment of nasopharyngeal cancer, IVM significantly inhibited the development of nasopharyngeal carcinoma in nude mice at doses that were not toxic to normal thymocytes [69]. In addition, IVM also had a cytotoxic effect on a variety of nasopharyngeal cancer cells in vitro, and the mechanism is related to the reduction of PAK1 kinase activity to inhibit the MAPK pathway.”
“Lung cancer has the highest morbidity and mortality among cancers [70]. Nishio found that IVM could significantly inhibit the proliferation of H1299 lung cancer cells by inhibiting YAP1 activity [43]. Nappi’s experiment also proved that IVM combined with erlotinib to achieved a synergistic killing effect by regulating EGFR activity and in HCC827 lung cancer cells [50]. In addition, IVM could reduce the metastasis of lung cancer cells by inhibiting EMT.”
“Gallardo treated melanoma cells with IVM and found that it could effectively inhibit melanoma activity [73]. Interestingly, IVM could also show activity against BRAF wild-type melanoma cells, and its combination with dapafinib could significantly increase antitumor activity. Additionally, it has been confirmed that PAK1 is the key target of IVM that mediates its anti-melanoma activity, and IVM can also significantly reduce the lung metastasis of melanoma in animal experiments. Deng found that IVM could activate the nuclear translocation of TFE3 and induce autophagy-dependent cell death by dephosphorylation of TFE3 (Ser321) in SK-MEL-28 melanoma cells [74]. However, NAC reversed the effect of IVM, which indicated that IVM increased TFE3-dependent autophagy through the ROS signaling pathway.”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835698/
“So far, at least 235 clinically-approved, non-cancer drugs have proven antitumor activity either in vitro, in vivo, or even clinically. Among these, ivermectin, an antiparasitic compound of wide use in veterinary and human medicine, is clearly a strong candidate for repositioning, based on the fact that i) it is very safe, causing almost no side-effects other than those caused by the immune and inflammatory responses against the parasite in infected patients, and ii) it has proven antitumor activity in preclinical studies. On the other hand, it is now evident that the use of very selective “unitargeted” drugs is commonly associated to early development of resistance by cancer cells, hence the use of “dirty” or “multitargeted” drugs is important to explore. In this sense, ivermectin has this potential as it modulates several targets such as the multidrug resistance protein (MDR), the Akt/mTOR and WNT-TCF pathways, the purinergic receptors, the PAK-1 protein, certain cancer-related epigenetic deregulators such as SIN3A and SIN3B, RNA helicase activity, while stimulates chloride channel receptors leading to cell hyperpolarization, and down-regulates stemness genes to preferentially target cancer stem-cell like population, at least in breast cancer. Importantly, the in vitro and in vivo antitumor activities of ivermectin are achieved at concentrations that can be clinically reachable based on the human pharmacokinetic studies done in healthy and parasited patients. Thus, existing information on ivermectin could allow its rapid move into clinical trials for cancer patients.”
https://www.sciencedirect.com/science/article/pii/S1043661820315152
“• Ivermectin effectively suppresses the proliferation and metastasis of cancer cells and promotes cancer cell death at doses that are nontoxic to normal cells.
• Ivermectin shows excellent efficacy against conventional chemotherapy drug-resistant cancer cells and reverses multidrug resistance.
• Ivermectin combined with other chemotherapy drugs or targeted drugs has powerful effects on cancer.
• The structure of crosstalk centered on PAK1 kinase reveals the mechanism by which ivermectin regulates multiple signaling pathways.
• Ivermectin has been used to treat parasitic diseases in humans for many years and can quickly enter clinical trials for the treatment of tumors.”
https://pubmed.ncbi.nlm.nih.gov/32474842/
“Purpose:
Ivermectin is an antiparasitic drug that exhibits antitumor effects in preclinical studies, and as such is currently being repositioned for cancer treatment. However, divergences exist regarding its employed doses in preclinical works. Therefore, the aim of this study was to determine whether the antitumor effects of ivermectin are observable at clinically feasible drug concentrations.
Methods:
Twenty-eight malignant cell lines were treated with 5 μM ivermectin. Cell viability, clonogenicity, cell cycle, cell death and pharmacological interaction with common cytotoxic drugs were assessed, as well as the consequences of its use on stem cell-enriched populations. The antitumor in vivo effects of ivermectin were also evaluated.
Results:
The breast MDA-MB-231, MDA-MB-468, and MCF-7, and the ovarian SKOV-3, were the most sensitive cancer cell lines to ivermectin. Conversely, the prostate cancer cell line DU145 was the most resistant to its use. In the most sensitive cells, ivermectin induced cell cycle arrest at G0-G1 phase, with modulation of proteins associated with cell cycle control. Furthermore, ivermectin was synergistic with docetaxel, cyclophosphamide and tamoxifen. Ivermectin reduced both cell viability and colony formation capacity in the stem cell-enriched population as compared with the parental one. Finally, in tumor-bearing mice ivermectin successfully reduced both tumor size and weight.
Conclusion:
Our results on the antitumor effects of ivermectin support its clinical testing.”
https://jeccr.biomedcentral.com/articles/10.1186/s13046-019-1251-7
“These findings demonstrated that ivermectin significantly enhanced the anti-cancer efficacy of chemotherapeutic drugs to tumor cells, especially in the drug-resistant cells. Thus, ivermectin, a FDA-approved antiparasitic drug, could potentially be used in combination with chemotherapeutic agents to treat cancers and in particular, the drug-resistant cancers.”
Hat tip to COUNTrecount. Pinging the list to Ivermectin use in cancer info. Freepmail to get on/off this ping list.
https://greatawakening.win/p/140vaI9zdq/ivermectin-cures-cancer/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043740/
“Ivermectin has powerful antitumor effects, including the inhibition of proliferation, metastasis, and angiogenic activity, in a variety of cancer cells. This may be related to the regulation of multiple signaling pathways by ivermectin through PAK1 kinase. On the other hand, ivermectin promotes programmed cancer cell death, including apoptosis, autophagy and pyroptosis. Ivermectin induces apoptosis and autophagy is mutually regulated. Interestingly, ivermectin can also inhibit tumor stem cells and reverse multidrug resistance and exerts the optimal effect when used in combination with other chemotherapy drugs.”
“IVM can inhibit the replication of flavivirus by targeting the NS3 helicase [17]; it also blocks the nuclear transport of viral proteins by acting on α/β-mediated nuclear transport and exerts antiviral activity against the HIV-1 and dengue viruses [18]. Recent studies have also pointed out that it has a promising inhibitory effect on the SARS-CoV-2 virus, which has caused a global outbreak in 2020 [19]. In addition, IVM shows potential for clinical application in asthma [20] and neurological diseases [21]. Recently scientists have discovered that IVM has a strong anticancer effect.”
“After treatment with IVM, the proliferation of multiple breast cancer cell lines including MCF-7, MDA-MB-231 and MCF-10 was significantly reduced.”
“IVM regulates the tumor microenvironment and mediates immunogenic cell death, which may be a new direction for research exploring anticancer mechanisms in the future.”
“Nambara’s study showed that IVM could significantly inhibit the proliferation of gastric cancer cells in vivo and in vitro and that the inhibitory effect of IVM depended on the expression of Yes-associated protein 1(YAP1)[39].”
“In a study that screened Wnt pathway inhibitors, IVM inhibited the proliferation of multiple cancers, including the colorectal cancer cell lines CC14, CC36, DLD1, and Ls174 T, and promoted apoptosis by blocking the Wnt pathway [41].”
“IVM could inhibit the development of hepatocellular carcinoma by blocking YAP1 activity in spontaneous liver cancer Mob1b-/- mice [43].”
“Experiments confirmed that IVM could significantly inhibit the proliferation of five renal cell carcinoma cell lines without affecting the proliferation of normal kidney cells, and its mechanism may be related to the induction of mitochondrial dysfunction [48].”
“In Nappi’s experiment, it was found that IVM could enhance the drug activity of the anti-androgen drug enzalutamide in the prostate cancer cell line LNCaP and reverse the resistance of the prostate cancer cell line PC3 to docetaxel [50]. Interestingly, IVM also restored the sensitivity of the triple-negative breast cancer to the anti-estrogen drug tamoxifen [36], which also implies the potential for IVM to be used in endocrine therapy. Moreover, IVM was also found to have a good inhibitory effect on the prostate cancer cell line DU145 [51].”
“In an experiment designed to screen potential drugs for the treatment of leukemia, IVM preferentially killed leukemia cells at low concentrations without affecting normal hematopoietic cells [51].”
“The majority of cervical cancers are caused by human papillomavirus (HPV) infection [54,55]. IVM has been proven to significantly inhibit the proliferation and migration of HeLa cells and promote apoptosis [56]. After intervention with IVM, the cell cycle of HeLa cells was blocked at the G1/S phase, and the cells showed typical morphological changes related to apoptosis.”
“In a study by Hashimoto, it found that IVM inhibited the proliferation of various ovarian cancer cell lines, and the mechanism was related to the inhibition of PAK1 kinase [58]. In research to screen potential targets for the treatment of ovarian cancer through the use of an shRNA library and a CRISPR/Cas9 library, the oncogene KPNB1 was detected. IVM could block the cell cycle and induce cell apoptosis through a KPNB1-dependent mechanism in ovarian cancer [59].”
“In a study that screened drugs for the treatment of nasopharyngeal cancer, IVM significantly inhibited the development of nasopharyngeal carcinoma in nude mice at doses that were not toxic to normal thymocytes [69]. In addition, IVM also had a cytotoxic effect on a variety of nasopharyngeal cancer cells in vitro, and the mechanism is related to the reduction of PAK1 kinase activity to inhibit the MAPK pathway.”
“Lung cancer has the highest morbidity and mortality among cancers [70]. Nishio found that IVM could significantly inhibit the proliferation of H1299 lung cancer cells by inhibiting YAP1 activity [43]. Nappi’s experiment also proved that IVM combined with erlotinib to achieved a synergistic killing effect by regulating EGFR activity and in HCC827 lung cancer cells [50]. In addition, IVM could reduce the metastasis of lung cancer cells by inhibiting EMT.”
“Gallardo treated melanoma cells with IVM and found that it could effectively inhibit melanoma activity [73]. Interestingly, IVM could also show activity against BRAF wild-type melanoma cells, and its combination with dapafinib could significantly increase antitumor activity. Additionally, it has been confirmed that PAK1 is the key target of IVM that mediates its anti-melanoma activity, and IVM can also significantly reduce the lung metastasis of melanoma in animal experiments. Deng found that IVM could activate the nuclear translocation of TFE3 and induce autophagy-dependent cell death by dephosphorylation of TFE3 (Ser321) in SK-MEL-28 melanoma cells [74]. However, NAC reversed the effect of IVM, which indicated that IVM increased TFE3-dependent autophagy through the ROS signaling pathway.”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835698/
“So far, at least 235 clinically-approved, non-cancer drugs have proven antitumor activity either in vitro, in vivo, or even clinically. Among these, ivermectin, an antiparasitic compound of wide use in veterinary and human medicine, is clearly a strong candidate for repositioning, based on the fact that i) it is very safe, causing almost no side-effects other than those caused by the immune and inflammatory responses against the parasite in infected patients, and ii) it has proven antitumor activity in preclinical studies. On the other hand, it is now evident that the use of very selective “unitargeted” drugs is commonly associated to early development of resistance by cancer cells, hence the use of “dirty” or “multitargeted” drugs is important to explore. In this sense, ivermectin has this potential as it modulates several targets such as the multidrug resistance protein (MDR), the Akt/mTOR and WNT-TCF pathways, the purinergic receptors, the PAK-1 protein, certain cancer-related epigenetic deregulators such as SIN3A and SIN3B, RNA helicase activity, while stimulates chloride channel receptors leading to cell hyperpolarization, and down-regulates stemness genes to preferentially target cancer stem-cell like population, at least in breast cancer. Importantly, the in vitro and in vivo antitumor activities of ivermectin are achieved at concentrations that can be clinically reachable based on the human pharmacokinetic studies done in healthy and parasited patients. Thus, existing information on ivermectin could allow its rapid move into clinical trials for cancer patients.”
https://www.sciencedirect.com/science/article/pii/S1043661820315152
“• Ivermectin effectively suppresses the proliferation and metastasis of cancer cells and promotes cancer cell death at doses that are nontoxic to normal cells.
• Ivermectin shows excellent efficacy against conventional chemotherapy drug-resistant cancer cells and reverses multidrug resistance.
• Ivermectin combined with other chemotherapy drugs or targeted drugs has powerful effects on cancer.
• The structure of crosstalk centered on PAK1 kinase reveals the mechanism by which ivermectin regulates multiple signaling pathways.
• Ivermectin has been used to treat parasitic diseases in humans for many years and can quickly enter clinical trials for the treatment of tumors.”
https://pubmed.ncbi.nlm.nih.gov/32474842/
“Purpose:
Ivermectin is an antiparasitic drug that exhibits antitumor effects in preclinical studies, and as such is currently being repositioned for cancer treatment. However, divergences exist regarding its employed doses in preclinical works. Therefore, the aim of this study was to determine whether the antitumor effects of ivermectin are observable at clinically feasible drug concentrations.
Methods:
Twenty-eight malignant cell lines were treated with 5 μM ivermectin. Cell viability, clonogenicity, cell cycle, cell death and pharmacological interaction with common cytotoxic drugs were assessed, as well as the consequences of its use on stem cell-enriched populations. The antitumor in vivo effects of ivermectin were also evaluated.
Results:
The breast MDA-MB-231, MDA-MB-468, and MCF-7, and the ovarian SKOV-3, were the most sensitive cancer cell lines to ivermectin. Conversely, the prostate cancer cell line DU145 was the most resistant to its use. In the most sensitive cells, ivermectin induced cell cycle arrest at G0-G1 phase, with modulation of proteins associated with cell cycle control. Furthermore, ivermectin was synergistic with docetaxel, cyclophosphamide and tamoxifen. Ivermectin reduced both cell viability and colony formation capacity in the stem cell-enriched population as compared with the parental one. Finally, in tumor-bearing mice ivermectin successfully reduced both tumor size and weight.
Conclusion:
Our results on the antitumor effects of ivermectin support its clinical testing.”
https://jeccr.biomedcentral.com/articles/10.1186/s13046-019-1251-7
“These findings demonstrated that ivermectin significantly enhanced the anti-cancer efficacy of chemotherapeutic drugs to tumor cells, especially in the drug-resistant cells. Thus, ivermectin, a FDA-approved antiparasitic drug, could potentially be used in combination with chemotherapeutic agents to treat cancers and in particular, the drug-resistant cancers.”
And a personal testimony from a FReeper:
I was diagnosed stage 4 breast cancer in January...it had spread to my spine. Tumors discovered with CT scan. Started Ibrance and Xgeva. Using an ongoing study at the NIH site on invermectin and prostate cancer, I added 12 mg of ivermectin to my chemo on Monday, Tuesday and Wednesday. Been doing this for 3 months. On June 22 had my baseline bone scan. NO EVIDENCE OF DISEASE (NED).
My oncologist knows I am taking ivermectin. His response to NED...”well, you don’t have worms either.”
Other things said, “you responded to the medicine better than most women,” “somebody is answering your prayers,” and “are you having any side effects from the horse wormer.”
It’s crazy.
Thank you, lj! I am going to send this info to a friend who has just been diagnosed with breast cancer.
too technical for me
However, I do know that Ivermectin has kept my melanoma at bay for 25 years.
Too techy for me too; I figured I’d put it out there for whatever can be gleaned from it. Or copied and shown to one’s doctor.
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