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Three clinical trials demonstrated positive results from the targeted therapy erdafitinib for patients with multiple tumor types harboring FGFR alterations. Erdafitinib blocks activity of FGFR signaling proteins. The tumor-agnostic Phase II RAGNAR trial confirmed the efficacy of erdafitinib in heavily pre-treated patients with advanced FGFR-altered solid tumors across 16 distinct cancer types. The overall response rate (ORR) was 29.5%, including six complete responses and 58 partial responses. The ORR was comparable across FGFR1-3 mutations and fusions. The treatment achieved a disease control rate of 73.7% and a clinical benefit rate of 45.6%, including an ORR of 56% in patients with...

Controversies surrounding hormone therapy (HT) and its benefits and risks have dominated the women's health field for more than 2 decades. A large new study demonstrates that, despite some commonly held misperceptions, HT doesn't increase a woman's risk of developing lung cancer, and it could actually help reduce the risk. Lung cancer remains one of the most common malignancies and the leading cause of cancer mortality worldwide. After breast cancer, it is the most common cancer in women, with its incidence increasing in women over the past few decades. Although smoking remains the number-one risk factor for developing lung cancer,...

Typically, in American schools, bullying is like the dark cousin to prom, student elections, or football practice: Maybe you weren’t involved, but you knew that someone, somewhere was. In 2011, President Obama spoke against this inevitability at the White House Conference on Bullying Prevention. “With big ears and the name that I have, I wasn’t immune. I didn’t emerge unscathed,” he said. “But because it’s something that happens a lot, and it’s something that’s always been around, sometimes we’ve turned a blind eye to the problem.” We know that we shouldn’t turn a blind eye: Research shows that bullying is...

A guide for detransitioners, lost-in-transitioners, and other survivors of gender malpractice Have you ever thought about filing a formal complaint with the licensing board of the therapist who provided your “gender-affirming care,” but felt too daunted to complete the process? Fear not. I’ve simplified it for you. It essentially comes down to two steps: finding the appropriate board to report to, and writing a letter. To help you with step 1, I’ll point you toward the right board to complain to. To help you with step 2, I’ve written a template you can use, and provided a sample letter based...

Continued treatment for patients with cancer near end-of-life escalates costs and may adversely affect the quality of care patients receive. Accordingly, over the last decade, major professional societies have recommended that clinicians decrease the use of systemic anti-cancer therapies at the end-of-life stage. Researchers revealed that despite these recommendations, aggressive cancer care at the end-of-life persists and there has been a substantial transition from the use of chemotherapy to immunotherapy. "Systemic anti-cancer therapy has changed dramatically following the approvals of multiple new targeted therapies," said Kerin Adelson, MD. Researchers used the nationwide Flatiron Health electronic health record (EHR)-derived database to...

Today the NY Times published an interview with a woman named Dea Bridge who advertises herself as a conservative therapist in Colorado. The first half of the podcast falls into what I would call the “Gorillas in the Mist” style of interview. Host Meghan Daum is asking questions about the boundaries of conservative therapy which seem to assume the worst about Bridge....Daum: Do you think that Donald Trump made everybody go crazy?Bridge: What do you mean by “made everybody go crazy”?Daum: In my world, I know a lot of people who were so distressed about the election of Trump that...

The Biden administration is launching a campaign pressuring other countries to encourage transgender treatments for children and abolish “conversion therapy,” according to a leaked internal memo obtained by the Manhattan Institute’s publication City Journal.In an August 31 report, Manhattan Institute fellow Leor Sapir wrote that he obtained an internal memo by Secretary of State Antony Blinken that had been leaked by an officer in the U.S. State Department’s Foreign Service.According to Sapir, the memo derives from U.S. President Joe Biden’s June Executive Order 14075 that instructs federal agencies to “safeguard LGBTQI+ youth” against “dangerous practices,” including “conversion therapy” for “LGBTQI+”...

Trump supporters have seen it all when it comes to being suppressed, de-platformed, and marginalized by big tech, including emails. The emails from Trumpsterz Tuesday Therapy get suppressed in my inbox. Having emails suppressed is incredibly annoying and outrageous. Months ago, I signed up to get the emails from a quirky named, fun-looking Trump club in the North End of Palm Beach County called the Trumpsterz Tuesday Therapy club. The name and the whimsical graphics caught my eye. Sometimes political clubs are so serious and swelled with self-importance that they’re boring.

Leukemia, the blood cancer, is a group of hematopoietic malignancies. Many types of leukemia are associated with poor outcome. Unfortunately, during the past few decades, the first-line leukemia therapy has long been traditional chemotherapy with high cytotoxicity and low selectivity, such as the "7+3" strategy, i.e., a combination of cytarabine and doxorubicin. Side effects of such intensive chemotherapies are often severe, especially in older patients. Therefore, it is an urgent need to understand the mechanisms of leukemia, and develop novel targeted therapy based on such comprehension. In this work, Jiang's group first found through drug screening that opioid receptor agonists,...

Nazi Mind Control Amidst the subtle cerebral circumvention of the gullible populace, through a multitude of manipulated mediums, lies one of the most diabolical atrocities perpetrated upon a segment of the human race; a form of systematic mind control which has permeated every aspect of society for almost fifty years.To objectively ascertain the following, one may need to re-examine preconceived ideologies relating to the dualistic nature of mankind. . . . . .This exposition is substantiated by declassified U.S. government documents, individuals formerly connected to the U.S. intelligence communities, historical writings, researchers knowledgeable in mind control, publications from mental health...

In order to go from 'zero' to 'hero' very rapidly and give Canadians a good shot at acquired immunity, Trudeau should: > Acknowledge the good intention of the truckers' protest, > Apologize to the nation for his dereliction of duty on the whole issue of VAXX Passports, > Declare an end to all COVID mandates and > Empower the Canadian health services to explore and use all tested and promoted therapeutic treatments (HCQ, Ivermectin*, zinc, vitamins C, D, and E, etc). *The Nobel Prize version, not the 'horse paste' version, of course (sarc) His next step would be to retire...

Researchers of a new study say that two patients with leukemia continued to be in remission a decade after they were first infused with the experimental CAR T-cell therapy that turned their immune cells into cancer-killing cells.In 2010, Doug Olson and Bill Ludwig, participated in an experimental phase 1 clinical trial of the immunotherapy, after their cancer had mutated and no longer responded to the standard treatments. Both were battling chronic lymphocytic leukemia (CLL), a type of blood and bone marrow cancer. Olsen was diagnosed in 1996 and Lugwig in 2000.Dr. Carl H. June, a senior author, and director of...

Abstract BackgroundCOVID-19 is a global pandemic. Treatment with hydroxychloroquine (HCQ), zinc, and azithromycin (AZM), also known as the Zelenko protocol, and treatment with intravenous (IV) vitamin C (IVC) have shown encouraging results in a large number of trials worldwide. In addition, vitamin D levels are an important indicator of the severity of symptoms in patients with COVID-19. ObjectivesOur multicenter, randomized, open-label study aimed to assess the effectiveness of HCQ, AZM, and zinc with or without IVC in hospitalized patients with COVID-19 in reducing symptom severity and duration and preventing death. MethodsHospitalized patients with COVID-19 in seven participating hospitals in Turkey...

Numbers showing the majority of Alberta's COVID-19 hospital admissions are in vaccinated individuals don't tell the entire story, regardless of what some conspiracy theorists believe. Albertans with at least one shot took over more hospital beds than those without this week. But the raw numbers are incomplete, and a dive into the data shows being vaccinated may be more important now than ever before. As of Thursday, 217 unvaccinated Albertans were in hospital with COVID-19, compared to 282 patients with at least one shot. But almost 90 per cent of the province has one dose, which means the "rate per...

Georgian tennis star Nikoloz Basilashvili was forced to drop out of the Sydney Cup due to breathing difficulties and needing treatment from a doctor during his singles match against Greece’s Stefanos Tsitsipas. The 29-year-old and World’s no. 22 tennis player had to end his ATP Cup match early due to breathing difficulties on Wednesday. A doctor and physiotherapist attended Basilashvili while sitting with his team.

At this year’s World Health Summit Stefan Oelrich, President of Bayer’s Pharmaceuticals Division, gave a truly eye-opening speech revealing how the so-called “experts” think and quite frankly, taking his speech in the round, it’s chilling.Every October, the World Health Summit draws international “experts” from academia, politics, the private sector, and civil society to Berlin. The 13th World Health Summit was held in Berlin over the 3 days 24 – 26 October 2021. There were 67 sessions with 377 speakers involving 6,000 participants from 120 nations. The Summit’s partners include: Sanofi, Johnson & Johnson, Pfizer, Roche, Wellcome, Biogen, Novartis, Bayer and...

Each year, the guardianship of thousands of vulnerable youth are signed over to private and for-profit residential programs that lack state and federal oversight. This means that these programs can be established fairly spontaneously and are not required to report what goes on within the facility to the state or federal government. These programs may label themselves as wilderness, therapeutic, boot camp, or religious programs, and are collectively known as the “troubled teen industry” (tti). The TTI operates out of sight and out of mind, typically in remote locations away from public scrutiny. It is a multi-billion dollar industry that...

Dr. Joseph Ladapo, the new Surgeon General and Secretary of the Department of Health for the state of Florida, denounced coronavirus hysteria on Tuesday, alleging it uses fear to rob people of their personal autonomy. [cut] After stepping up to the podium, Ladopo declared that the Sunshine State is “done with fear.” “We’re done with fear. It’s been something that’s been, unfortunately, a centerpiece of health policy in the United States ever since the beginning of the pandemic, and it’s over here — expiration date is done,” he said. In the same speech, Ladopo touted the importance of vaccines while...

The Biden administration this week slashed the doses of lifesaving coronavirus antibody treatment to Florida, giving the state less than half of what is needed for a routine week, prioritizing “equitable distribution” — a move some suspect is a form of revenge against Republican governors whom the president vowed to get “out of the way.” The Biden administration this week began to cut the distribution of monoclonal antibodies to red states, such as Florida and Alabama, contending those states, including Texas, Mississippi, Tennessee, Georgia, and Louisiana, are comprising too big a share of the supply in recent weeks — 70...

What guns have you sold that you miss dearly? I miss my High Standard AR 15 sn 107. made in Tx, a tack driver...