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High blood pressure, or hypertension, remains a global health concern, contributing to 19% of deaths worldwide. In an international review, biologists highlight the pivotal role of dietary fiber in managing hypertension and reducing cardiovascular disease (CVD) risk, and call for the inclusion of dietary fiber in clinical guidelines for hypertension. The review sheds light on the often-overlooked importance of dietary fiber in blood pressure management. Said Francine Marques, "Dietary fiber has emerged as a crucial yet underappreciated part of hypertension management." "Our comprehensive analysis emphasizes the evidence supporting the effectiveness of dietary fiber in lowering blood pressure and reducing the...

Dendritic cells play a key role in the mammalian immune system. These cells are present throughout the human body and are known to capture foreign bodies, or antigens, using extendable "arms" called dendrites. Once captured, dendritic cells present these substances to immune T cells, thereby initiating an immune response. Dendritic cells are responsive to their environment. For instance, dendritic cells in the intestine's mucosa (inner layer) capture harmful bacteria by extending their dendrites through the epithelium (outermost layer) and into the intestinal lumen (inner space). Researchers found short-chain fatty acids (SCFAs) produced by intestinal bacteria are responsible for initiating the...

Metabolites produced by gut bacteria during digestion can be used to trigger an immune response against colorectal cancer cells, according to new research that points toward a potential treatment for one of the deadliest forms of cancer. The research team found that the metabolites activate a molecule on the surface of the cancer cells that attracts immune cells, called T cells. The metabolites are also able to enter the nucleus of the cancer cells and alter their DNA, which further attracts the attention of the immune system. "What we saw is that these products regulate a key molecule on the...

Based on the long-time claim by General Mills that its Cheerios cereal can lower cholesterol by 4 percent in just six weeks — when part of a diet low in saturated fat and cholesterol, of course — the Food and Drug Administration has admonished the giant breakfast cereal producer and said those claims mean the little round “o’s” of oats are to be considered a drug. Simply by indicating the cereal is intended for use as a cholesterol-lowering product, it now falls under the FDA regulations regarding drugs, and because it’s a “new” drug by definition — never mind that...

A new University of Illinois study touts the benefits of soluble fiber -- found in oats, apples, and nuts, for starters -- saying that it reduces the inflammation associated with obesity-related diseases and strengthens the immune system. This happens because soluble fiber causes increased production of an anti-inflammatory protein called interleukin-4, he said. Scientists have long known that obesity is linked to inflammatory conditions, such as diabetes and heart disease. Yet, in a recent study, the U of I scientists demonstrated that fat tissue produces hormones that appear to compensate for this inflammation. "There are significant anti-inflammatory components in fat...