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  • Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro

    03/24/2020 12:35:18 AM PDT · by kire555 · 19 replies
    Open Access ^ | 3/18/2020 | Jia Liu , Ruiyuan Cao , Mingyue Xu , Xi Wang , Huanyu Zhang , Hengrui Hu , Yufeng Li , Zhihong Hu ,
    The outbreak of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome cor- onavirus 2 (SARS-CoV-2/2019-nCoV) poses a serious threat to global public health and local economies. As of March 3, 2020, over 80,000 cases have been confirmed in China, including 2946 deaths as well as over 10,566 confirmed cases in 72 other countries. Such huge num- bers of infected and dead people call for an urgent demand of effective, available, and affordable drugs to control and diminish the epidemic. We have recently reported that two drugs, remdesivir (GS-5734) and chloroquine (CQ) phosphate, efficiently inhibited SARS-CoV-2 infection in...