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Keyword: pyruvate

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  • Dietary pyruvate targets cytosolic phospholipase A2 to mitigate inflammation and obesity in mice

    07/23/2024 2:59:12 PM PDT · by ConservativeMind · 11 replies
    An article discusses the multifactorial nature of obesity, highlighting its association with chronic low-grade inflammation, or meta-inflammation, which contributes to metabolic disorders. Pyruvate was found to inhibit adipogenic differentiation in vitro and significantly prevent HFD-induced weight gain and inflammation in mice. The study underscores pyruvate's potential as a therapeutic option for obesity, given its previous clinical use and safety. Key findings from the study include: Pyruvate reduced intracellular lipid and triglyceride accumulation, indicating its effectiveness in suppressing adipogenesis across different cell types. In vivo experiments with male mice indicated that pyruvate administration significantly prevented HFD-induced weight gain and central adiposity....