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Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative diseases that commonly occur in middle-aged people. Both ALS and FTD arise from neuronal degeneration through mechanisms that remain unclear. Dr. Yun-Ru (Ruby) Chen's team recently discovered a new pathological mechanism for neuronal degeneration using synthetic peptides. They also discovered that a disaccharide can increase neuronal survival and reduce degeneration. The result provides therapeutic strategies for future treatment. ALS and FTD differ in clinical symptoms, but they share many pathological features and genetic variations. Clinical data shows that more than 90% of ALS and about 70% of FTD patients are...

In addition to antibodies and white blood cells, the immune system deploys peptides to fight viruses and other pathogens. Synthetic peptides could reinforce this defense but don't last long in the body, so researchers are developing stable peptide mimics. Today, scientists report success in using mimics known as peptoids to treat animals with herpes virus infections. These small synthetic molecules could one day cure or prevent many kinds of infections, including COVID-19. The researchers will present their results at the fall meeting of the American Chemical Society (ACS). ACS Fall 2021 is a hybrid meeting being held virtually and in-person...