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Keyword: p53pathway

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  • Immortality improves cell reprogramming - Knocking out genes with a role in cancer prevention...

    08/13/2009 11:36:46 AM PDT · by neverdem · 5 replies · 449+ views
    Nature News ^ | 9 August 2009 | Elie Dolgin
    Knocking out genes with a role in cancer prevention helps produce stem cells.Switching off the p53 pathway helped researchers to make stem-like cells.Wikimedia Commons Specialized adult cells made 'immortal' through the blockade of an antitumour pathway can be turned into stem-like cells quickly and efficiently.The findings — which should make it easier to generate patient-specific cells from any tissue type, including certain diseased cells that have proved difficult to transform — suggest that cellular reprogramming and cancer formation are inextricably linked.Since 2006, when Shinya Yamanaka of Japan's Kyoto University first created induced pluripotent stem (iPS) cells1 — which can develop...