Osteoarthritis is a wear-and-tear disorder marked by bone thickening and cartilage degeneration, an excruciatingly painful disability and a major cause of impaired mobility as people age. But scientists have begun viewing this form of arthritis differently with a deeper understanding of the disorder's causes and an eye toward personalized medicine as a treatment option. Although for decades medical experts have focused on problems such as the pain caused by bone thickening and the disappearance of cartilage, scientists say bone malalignment may play a critical role in osteoarthritis. In a novel clinical study, medical scientists demonstrate how the alignment problem can...