MSNBC “Hardball” host Chris Matthews told his staff tonight that he will not be running for the U.S. Senate in 2010 from Pennsylvania, ending months of mind-numbing speculation. That move bumps up the profiles of the lesser known but more qualified possible Democratic contenders: State Rep. Josh Shapiro and U.S. Rep. Patrick Murphy -- both of whom hail from eastern Pennsylvania. Whoever wins that spot would possibly face incumbent Republican Sen. Arlen Specter, depending on whether Pennsylvania’s longest-serving senator is “primaried” or not next spring. Specter faced a grueling