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Researchers are behind a new discovery that tells us how associated neurodegenerative diseases might develop. At the center of this discovery stands a molecule called NAD, or nicotinamide adenine dinucleotide. Nutrients, such as sugar or fat, are converted to a universal form of energy that our cells can use to maintain all energy-demanding functions. "NAD is central to these conversions as it functions like a rechargeable battery. An important part of this energy transfer takes place in cellular structures called mitochondria," Ziegler explains. Crucially, NAD also contributes to many other vital functions throughout the cell. It serves as a chemical...

A combination of intermittent fasting and a specialized biomedical bandage can restore bone healing in aged mice to levels seen in young animals, according to research. "Key to bone repair is a type of cell called osteoprogenitors, which create new bone tissue," explains Joshua Reeves. First, they analyzed the changes that occur in the bone of mice during aging, finding a clear decline in both bone structure and healing capacity with age. The team noticed a reduction in blood vesselspwithin periosteal bone-forming tissue, beginning in adulthood. They also observed changes in aging osteogenic (bone-forming) compartments, including increased actin levels and...

We live longer and longer, and as we age, a lot of us develop a series of health issues and chronic diseases, including chronic obstructive pulmonary disease (COPD), which is found in around 600 million individuals globally. However, only half of them know they have the disease. COPD patients often experience shortness of breath, persistent cough with mucus, wheezing and frequent respiratory infections, which can make everyday activities difficult. Now a study suggests that a form of vitamin B3 may be the key to improving quality of life for these patients. "In the study, we show that nicotinamide riboside, also...

Glaucoma is the leading cause of irreversible blindness worldwide. The condition occurs when cells in the eye that help you see (called retinal ganglion cells) start to die. The main risk factors for glaucoma are high eye pressure and older age. Currently, all licensed treatments are designed to lower pressure in the eye—also known as intraocular pressure. However, some patients still continue to lose their sight following treatment. To help doctors better understand who will lose their vision faster, the study asked whether mitochondrial function, measured in white blood cells, is lower in people with glaucoma than those without glaucoma...

A substance naturally occurring in pomegranates, strawberries and walnuts can improve memory and treatment of Alzheimer's disease, a new study concludes. Forgetfulness, difficulty finding words and confusion about time and place. These are some of the most common symptoms of Alzheimer's disease. Now researchers have discovered that an ordinary fruit can help. "Our study on mouse models with AD shows that urolithin A can alleviate memory problems and other consequences of dementia," says Vilhelm Bohr. "Even though the study was conducted on mouse models, the prospects are positive. So far, research has shown promising results for the substance in the...

A research consortium led by Nestlé Research in Switzerland made a recent discovery that the natural molecule trigonelline present in coffee, fenugreek, and also in the human body, can help to improve muscle health and function. The work builds on a previous collaborative study that described novel mechanisms of human sarcopenia. Sarcopenia is a condition where cellular changes that happen during aging gradually weaken the muscles in the body and lead to accelerated loss of muscle mass and strength and reduced physical independence. One important problem during sarcopenia is that the cellular cofactor NAD+ declines during aging, while mitochondria, the...

Roughly one million people die of untreated kidney failure, worldwide, each year. Despite the major personal and economic burden, only a few new approaches have been deployed to treat or cure kidney disease over the last 40 years. Metabolic changes related to an enzyme "helper molecule"—called nicotinamide adenine dinucleotide (NAD)—may serve as the basis for a future treatment or preventive measure for kidney disease, according to a discovery by a new study. Metabolic changes related to NAD may offer a new therapeutic target to improve the course of kidney disease. By mapping metabolite changes in healthy and diseased mouse and...

Heart failure is often identified only when the heart has already deteriorated. This is in large part because the cause is unknown for about 70% of people who experience heart failure. Researchers have discovered that one of the earliest signs of heart failure is a change in how the heart produces energy, with findings offering a potential way to preempt heart failure before the heart begins to deteriorate. Led by Dr. Paul Delgado-Olguín, the research may help explain the diversity of causes underlying heart failure. "We were surprised to find that dysregulation of energy production was the earliest sign of...

New year, same topics: nutrition, healthy eating and slowing the downhill roll of aging. Eat this, not that — never that — and try this one weird thing to look younger, right? Advice spans the spectrum from dubious to scientifically supported, but there is an approach that sidesteps it all: eat less. Either in a specific time frame or in general, limiting calories safely is called caloric restriction, food restriction or fasting. It’s not a new idea, but fasting as a health practice hasn’t taken off, and Eduardo Chini, M.D., Ph.D., a Mayo Clinic researcher, knows why. “One of the...

Health issues for people over age 60 commonly involve eye-related conditions such as dry eyes. More than 70% of people in this age group are believed to suffer from meibomian gland disorder, the most common cause of dry eyes. A study reports that the loss of sex steroid hormones produced by the enzyme 3-hydroxyl-steroid dehydrogenase, or 3-HSD, causes the condition, but it can be treated with nicotinamidemononucleotide, or NMN, which is a non-steroid agent. "Meibomian glands are found in the eyelids and have a role in producing the oil that coats the eyes. Without this oil, tears evaporate, " notes...

Joe Rogan and Michael Malice discussed last week why the corporate press continues to dismiss ways doctors can treat Covid-19 aside from vaccination. Rogan said that Dr. Pierre Kory from the Front Line Critical Care Covid group treated him and hundreds of members of Congress with monoclonal antibodies, prednisone, z-pak, NAD, vitamins, and ivermectin. ... 200 Congress people have been treated with Ivermectin for Covid. .. Before there were vaccines, this was a common off-label treatment for Covid. "I do not know the motivation for demonizing this particular medication .. But I would imagine some of it has to do...

really good analysis by david limbaugh... New Orleans and Race -- Revisited By: David Limbaugh Some conservatives are concerned with President Bush's New Orleans speech because of the unlimited federal spending it seemed to promise, but I was far more concerned with his arguable vindication of the wrongheaded notion that racial discrimination is responsible for the disproportionate impact of the flooding on blacks. After all, opening up the federal coffers for a disaster is far less objectionable than so many of the projects presently funded by the government. And, the president is using this as an opportunity to launch market-based...

The Council of Better Business Bureaus has recommended that Apple Computer discontinue comparative performance claims regarding its Power Mac G5 desktop. Acting on a tip from Apple rival Dell, the council's National Advertising Division (NAD) "determined that the evidence provided by Apple did not provide a reasonable basis for its broad unqualified claims that its Power Mac G5 is 'the world's fastest, most powerful personal computer' and that it 'edged out the competition on integer.'"

The National Association of the Deaf (NAD) urged President Bush to overturn a recent decision by the U.S. Department of Education to declare almost 200 television shows inappropriate for captioning by the Department’s Technology and Media Services for Individuals with Disabilities program, effective October 1, 2003. According to NAD President, Andrew J. Lange, the Department's action is government censorship and contradicts President Bush’s promotion of family values and parental accountability. Under the current guidelines, applicants for captioning grants take into account the preferences of consumers, through grantee Consumer Advisory Boards (CABs) and other feedback mechanisms, when selecting “educational, news, or...