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Newly discovered mechanism reveals NAD's role in aging and disease
Medical Xpress / University of Bergen / Nature Metabolism ^ | Dec. 23, 2024 | Lena E. Høyland et al

Posted on 12/25/2024 6:38:09 PM PST by ConservativeMind

Researchers are behind a new discovery that tells us how associated neurodegenerative diseases might develop. At the center of this discovery stands a molecule called NAD, or nicotinamide adenine dinucleotide.

Nutrients, such as sugar or fat, are converted to a universal form of energy that our cells can use to maintain all energy-demanding functions.

"NAD is central to these conversions as it functions like a rechargeable battery. An important part of this energy transfer takes place in cellular structures called mitochondria," Ziegler explains.

Crucially, NAD also contributes to many other vital functions throughout the cell. It serves as a chemical signal to regulate key cellular events including gene expression and DNA repair, which take place in the cell nucleus.

"Interestingly, during aging, our DNA may accumulate damage which, in turn, will increase the demand for NAD molecules. Indeed, we see that cellular NAD levels decrease as we age," explains Ziegler. "The problem arises when the mitochondria or their NAD store are affected or tapped over extended periods of time."

"These organelles serve as an NAD reservoir that is filled when cells function normally, and it supplies the cell with NAD when there is an increased demand," explains Lena Høyland, Ph.D. student.

"Decreased cellular NAD levels thus appear to be generally well tolerated by the cells," she says.

"The problem, however, arises when the mitochondria or their NAD store are affected or tapped over extended periods of time. This can have fatal consequences since the cells may no longer have sufficient NAD 'battery capacity,’" Professor Ziegler adds.

Research in recent years has established that mitochondrial dysfunction and lowered cellular NAD levels represent characteristics of aging, and age-related disorders, such as dementia or neurodegenerative diseases.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: aging; nad; nads; nicotinamideriboside; r
You can purchase precursors to NAD. I have previously taken higher doses of nicotinamide riboside, but after a study describes how too much at once can create detrimental substances, we bought nicotinamide riboside powder and I am dosing 1/64 of a teaspoon a day, which should be at a level that shouldn’t create bad substances.
1 posted on 12/25/2024 6:38:09 PM PST by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; jy8z; ProtectOurFreedom; matthew fuller; telescope115; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

2 posted on 12/25/2024 6:38:37 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Mark.


3 posted on 12/25/2024 6:44:21 PM PST by thesearethetimes... (Had I brought Christ with me, the outcome would have been different. Dr.Eric Cunningham)
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To: ConservativeMind

Soooo...it depends on your age, right? Not clear how much is too much.


4 posted on 12/25/2024 7:05:38 PM PST by goodnesswins (Don’t be REALITY PHOBIC!)
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To: goodnesswins

I believe that nads shrink with age. Could be a factor.


5 posted on 12/25/2024 7:10:59 PM PST by Larry Lucido (Donate! Don't just post clickbait!)
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To: goodnesswins

It seems to be how much your body needs for its condition, which would be hard to truly understand. It’s not the “one size fits all” it was believed to be.

If your health is poor, you could benefit more from more normal sized doses. People with COPD appear to need fairly more, to help with some healing, for instance.

Younger people don’t seem to need it much, or at all, however, their primary antioxidants and processes are still fully functioning.


6 posted on 12/25/2024 7:11:15 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

[Nutrients, such as sugar or fat]

Excellent. I’ve been taking Nutrients for decades now.


7 posted on 12/25/2024 7:23:42 PM PST by SaveFerris (Luke 17:28 ... as it was in the Day's of Lot; They id Eat, They Drank, They Bought, They Sold ......)
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To: ConservativeMind

The most affordable and convenient NAD precursor is NMN (nicotinamide mononucleotide). I take 1g (1/2 tsp) in powder form under my tongue before food in the morning since it breaks down with digestion. There is also a capsule form if you prefer. You probably don’t need it until age 45 when your natural levels decline.

I feel more energy during the day and sleep better at night. Other people report better performance in sports and exercise. In the long term, the goal is a longer life without mental decline.

Amazon has sold untested and mislabeled NMN products in the past. I would only trust an independently tested source from DoNotAge.com in the UK.


8 posted on 12/25/2024 7:25:02 PM PST by Dave Wright
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To: ConservativeMind

Might check out Methylene Blue for NAD.

the book’s available at amazon or as a pdf, here’s the summary short form.

https://www.shortform.com/pdf/the-ultimate-guide-to-methylene-blue-pdf-mark-sloan

” . . .Methylene blue is gaining recognition as a potential therapy for disorders characterized by the progressive degeneration of the nervous system.
Sloan highlights the potential benefits of methylene blue in addressing cognitive dysfunction, particularly in conditions such as Alzheimer’s and Parkinson’s. He argues that current medical strategies for treating dementia fall short because they focus too much on genetics and fail to tackle the fundamental metabolic causes of the disease.

Methylene blue impedes the formation of tau aggregates associated with Alzheimer’s and prevents the build-up of amyloid deposits.
Sloan references a 2017 study which suggests that the primary factor behind the development of neurological conditions such as Alzheimer’s and Parkinson’s is the decline in brain metabolism associated with aging. Mark Sloan characterizes methylene blue as a formidable partner in the fight against dementia, largely because it significantly gathers in the brain’s tissues and has the ability to counteract the influence of nitric oxide.

Sloan addresses the common misconception that Alzheimer’s disease is caused by a shortage of acetylcholine. Mark Sloan presents a counterargument to the common perception by asserting that, as the brain ages, there is an actual increase in the concentration of acetylcholine, which could worsen the situation if these levels are further heightened. He proposes that the main approach to tackling Alzheimer’s should focus on lowering levels of acetylcholine.

Methylene blue enhances mental functions by elevating metabolic processes that generate energy in the brain.
In a pioneering study conducted in 2019, the author examines the impact of daily methylene blue administration in quantities of 8 to 16 milligrams on individuals diagnosed with Alzheimer’s disease. Research has indicated a significant decrease in cognitive decline, achieving an 85% reduction and effectively halting the progression of the disease.

Sloan describes Alzheimer’s as a condition primarily marked by two metabolic hurdles: a reduction in the brain’s glucose supply and impaired activity of mitochondrial complex IV. . .” . . .


9 posted on 12/25/2024 7:40:37 PM PST by Norski
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To: Dave Wright
That company seems to sell its own stuff. Where do they have their testing of other brands? I know NOW Foods does some of that.

I use ConsumerLab.com, which truly tests all sorts of brands and does not sell any of them.

10 posted on 12/25/2024 7:46:12 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

bump for later


11 posted on 12/25/2024 7:53:41 PM PST by Bob434
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To: ConservativeMind; All

This has links to the free study that found a metabolite from NAD creation has some bad effects:

https://pubmed.ncbi.nlm.nih.gov/34580423/

Strangely, early nicotinamide riboside studies pointed to the creation of a large amount of 4-pyridone-3-carboxamide-1-β-D-ribonucleoside (4PYR) as a good indication that the supplementation was making what the body needed. Of course, there are multiple metabolites the body makes, but this bad one appears to come from an excess situation, from other items I read. It would seem better to time-release it, not have a big dose all at once.


12 posted on 12/25/2024 7:56:37 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Thanks


13 posted on 12/25/2024 8:01:34 PM PST by goodnesswins (Don’t be REALITY PHOBIC!)
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To: Dave Wright

OK, if FDA has banned sales in the US, how are people buying it?


14 posted on 12/25/2024 8:14:34 PM PST by Timothy
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To: ConservativeMind

Thanks, saving for later.


15 posted on 12/25/2024 8:21:34 PM PST by grey_whiskers (The opinions are solely those of the author and are subject to change without notice.)
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To: ConservativeMind

Ltr.


16 posted on 12/25/2024 8:41:13 PM PST by hdbc
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To: Dave Wright

Renue by Science is excellent as well if you are looking for a third party tested US product. I take NMN Lipo (500 mg) in tablet form every morning and notice

As per the latest findings NR seems to cross the blood-brain barrier more effectively than NMN, which is why it has been showing up as a candidate for a treatment for neurodegenerative conditions (COPD, Parkinsons, Alzheimers). NMN helps with apoptosis, endothelial cells to form new blood vessels, inflammation blood flow and circulatory issues.

https://www.cell.com/iscience/pdf/S2589-0042(24)02883-9.pdf


17 posted on 12/25/2024 10:41:26 PM PST by erlayman (E )
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To: erlayman

Renue by Science is excellent as well if you are looking for a third party tested US product. I take NMN Lipo (500 mg) in tablet form every morning and definitely notice a few hours later when there is a reopening of blood vessels that may have narrowed in response to cold or stress.

As per the latest findings NR seems to cross the blood-brain barrier more effectively than NMN, which is why it has been showing up as a candidate for a treatment for neurodegenerative conditions (COPD, Parkinsons, Alzheimers). NMN helps with apoptosis, endothelial cells to form new blood vessels, inflammation blood flow and circulatory issues.

https://www.cell.com/iscience/pdf/S2589-0042(24)02883-9.pdf


18 posted on 12/25/2024 10:48:35 PM PST by erlayman (E )
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To: ConservativeMind

That’s my favorite sportsball team, the Nads. Our battle cry is ‘Go Nads!’


19 posted on 12/25/2024 11:33:55 PM PST by asformeandformyhouse (I've been listening to a lot of rap music lately. Mostly at red lights and stop signs.)
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To: Larry Lucido
There was an intramural basketball team at my high school called The Nads.


20 posted on 12/26/2024 12:47:42 AM PST by gundog (It was a bright cold day in April, and the clocks were striking thirteen. )
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