IL-6 family proteins can promote inflammation, arthritis, autoimmune disease and even cancer. However, a study reveals the importance of IL-6 and associated genes for maintaining and regenerating cartilage in both the joints and in the growth plates that enable skeletal growth in children. "We show that the IL-6 family, previously associated with arthritis, bone and muscle loss, and other chronic inflammatory diseases, is required for the maintenance of skeletal stem and progenitor cells, and for the healthy growth and function of the joints and spine," said author Denis Evseenko. "Our study establishes a link between inflammation and regeneration, and may...