A massive fire on Thursday destroyed the upstate New York set of a new HBO series starring Mark Ruffalo and Rosie O’Donnell. The upcoming “I Know This Much Is True,” also featuring Melissa Leo and Juliette Lewis, had been filming in a used car dealership in Ellenville before flames tore through the site at 1 a.m. “There’s nothing left,” general manager Chris Busby told the Poughkeepsie Journal. “It’s a huge loss for us and HBO. They are just as heartbroken over this as we are.”