A new class of drugs that inhibits a “master switch” involved in the vast majority of cases of mantle cell lymphoma (MCL), a fatal subtype of non-Hodgkin’s lymphoma, has been discovered by researchers at Mount Sinai. In a study in Clinical Cancer Research published in June, the team reported that the drugs, known as small-molecule inhibitors of the SOX 11 oncogene, are toxic to MCL tumor development in human cells studied outside the body. If the effect is replicated in living patients, the discovery could lead to new therapies for a disease that is highly resistant to existing treatments. “The...