Efficacy of antidepressants in adults BMJ 2005;331:155-157 (16 July), doi:10.1136/bmj.331.7509.155Joanna Moncrieff, senior lecturer in social and community psychiatry1, Irving Kirsch, professor of psychology2 1 Department of Mental Health Sciences, University College London, London W1N 8AA, 2 School of Health and Social work, University of Plymouth, PlymouthCorrespondence to: J Moncrieff j.moncrieff@ucl.ac.uk Most people with depression are initially treated with antidepressants. But how well do the data support their use, and should we reconsider our strategy? Introduction TopIntroductionEfficacySeverity of depressionMethodological issues in...Effect of antidepressantsConclusionsReferences The National Institute for Health and Clinical Excellence (NICE) recently recommended that antidepressants, in particular selective serotonin reuptake inhibitors,...