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Metabolites produced by gut bacteria during digestion can be used to trigger an immune response against colorectal cancer cells, according to new research that points toward a potential treatment for one of the deadliest forms of cancer. The research team found that the metabolites activate a molecule on the surface of the cancer cells that attracts immune cells, called T cells. The metabolites are also able to enter the nucleus of the cancer cells and alter their DNA, which further attracts the attention of the immune system. "What we saw is that these products regulate a key molecule on the...

Over the past decade, the approval of immune checkpoint inhibitors has revolutionized treatment for patients with advanced lung cancer, helping many live longer lives and improving overall survival for the disease. However, an important question has remained unanswered: How long should a patient with advanced non-small cell lung cancer (NSCLC), who receives immunotherapy as part of their initial treatment, continue with treatment? A new retrospective cohort study suggests that it's reasonable to stop immunotherapy treatment at two years as long as their cancer hasn't progressed. The researchers found no statistically significant difference in overall survival between patients who stopped treatment...

A new study found a pro-inflammatory diet is associated with an increased risk of relapse in multiple sclerosis (MS) patients. The researchers found a more pro-inflammatory diet is associated with a higher risk of relapses and more inflammatory brain lesions for MS patients in the years following their first disease attack. MS is an autoimmune disease characterized by chronic inflammation that can damage nerve cells. A pro-inflammatory diet as per the study includes foods containing high amounts of fats and proteins. These foods are thought to drive chronic inflammation and immune dysregulation that could affect the course of MS. The...

I tried to tell you. And so did others. The word has finally gotten out to the world–or at least that part of it that is not under an information blackout (self-imposed or otherwise). I’m from the old school. The “show me, don’t tell me” school. The Teddy Roosevelt, “Walk softly but carry a big stick” school. But every once in a while–when appropriate and timely–it’s good to show your “bona fides.” After we were hit with COVID-19 at the beginning of 2020, I started to post blogs and videos about it. It was obvious to many of us that...

Natural immunity to disease is, or at least was, a well-known concept in medicine. By disease, I mean viral infections. One can’t develop natural immunity to diseases like diabetes or heart failure. Many of us remember “chicken pox parties” where when one kid was infectious, he or she was invited over to play with your kids, so they all got infected and then they did not have to worry about getting chicken pox again, due to natural immunity. The CDC defines it as follows: “Natural immunity is acquired from exposure to the disease organism through infection with the actual disease.”...

Among cancer patients who developed cardiotoxicity after treatment with immune checkpoint inhibitor (ICI) therapy, those treated with abatacept (Orencia), ruxolitinib, and/or mechanical ventilation as needed had a significantly lower mortality rate than those treated with standard-of-care corticosteroids. Immune checkpoint inhibitors, in rare cases, lead to an overactive immune system that can attack muscle cells known as myocarditis when it involves the heart muscle, which occurs in approximately 1% of patients receiving ICI therapy. Patients are typically given high-dose corticosteroids. Salem hypothesized directly targeting the autoreactive T cells may improve survival. Abatacept prevents macrophages from activating T cells and is sometimes...

Eric Clapton bravely discusses his neurological COVID-19 vaccine injuries... Why does Eric Clapton’s story matter? He may have been injured by two doses of the AstraZeneca COVID-19 vaccine, but this is not just an “AstraZeneca issue”. This is a spike protein issue - regardless of the platform that delivers the spike protein into your body (Pfizer, Moderna, J&J, AstraZeneca, Novavax, Sputnik, Covishield). Internationally renowned DJ, composer, songwriter Tyson Illingworth suffers Moderna vaccine injuries..

Helicobacter pylori is a bacterium that colonizes the stomach lining and is found in more than half of the global population. Most people with an H. pylori infection have no symptoms, but it can result in gastric ulcers and even stomach cancer. A study has found that seropositivity for the bacteria—meaning a blood test has confirmed the presence of antibodies against a previous H. pylori infection—may decrease the response to immunotherapy in people with metastatic melanoma, an advanced skin cancer. Dr. Marion Tonneau led the study as part of a team under Dr. Bertrand Routy. They found that patients who...

Project Veritas is back with a vengeance. Elon reinstated their deleted Twitter account and they’ve been taking aim at Big Pharma with redoubled vigor.But targeting Pfizer is nothing new for Project Veritas. You’ll recall back in 2021, they jumped head-fist into the “vax mandate” debate by publishing a 10-minute video showing Pfizer scientists touting the benefits of natural immunity.Washington Times:“When somebody is naturally immune, like, they got COVID, they probably have better – not better, but more antibodies against the virus,” says Mr. Karl in the hidden-camera footage. “Because what the vaccine is, like I said, that protein that’s just...

Well, here's the medical facts that entirely explain why people with more shots get more covid. I've been paying attention to this possibility for a while but until the study work came out that proved it all there was is speculation. ADE ("Antibody dependent enhancement") is a fairly poorly-understood thing; most people believe it is confined to making a particular infection more serious than it would otherwise be. Of course having it occur when it otherwise would not fits that quite-nicely, but isn't what people tend to think about. Now, unfortunately, we have the evidence. Here's the salient graph and...

Patients taking efgartigimod, a drug being studied for use to treat chronic primary immune thrombocytopenia (ITP), exhibited a significantly greater improvement in platelet counts which are essential to clotting and stopping bleeding, compared to those taking a placebo, according to results reported from the ADVANCE IV clinical trial. People with ITP have a type of autoantibody (antibodies directed against a person's own proteins) called immunoglobulin G (IgG) that increases the clearance of platelets from the circulation and can also reduce platelet production. ITP can be very difficult to treat, especially in patients who have not responded well to previous ITP...

[H/T Rusty0604]New research conducted by Moderna in partnership with the Kaiser Permanente health care group reveals that the company’s messenger RNA-based (mRNA) Wuhan coronavirus (Covid-19) “vaccines” cause the immune system to turn against itself in just a few months.Also known as negative efficacy, the phenomenon involves progressive immune degradation in a manner similar to AIDS and other autoimmune diseases. In essence, the “fully vaccinated” become walking immune time bombs that Moderna claims require additional injection intervention.It appears that the only reason Moderna even piloted this new damning study is to market new and additional shots to “fix” the problem created...

A lifelong promoter of vaccines suspects he might be the rare, unfortunate exception. On september 22 of last year, Michel Goldman, a Belgian immunologist and one of Europe’s best-known champions of medical research, walked into a clinic near his house, rolled up his sleeve, and had a booster shot delivered to his arm. He knew he’d need it more than most. Just a few weeks earlier, Michel, 67, had been to see his younger brother, Serge, the head of nuclear medicine at the hospital of the Université Libre de Bruxelles, where both men are professors. Michel was having night sweats,...

People who got “vaccinated” for the Wuhan coronavirus (Covid-19) while in remission for cancer are finding that their cancer has returned. Bonnie Eisenberg, a 73-year-old who has been eight years in remission for breast cancer, is one such person who thought she was done with her disease in 2014. Up until the time she got jabbed, Eisenberg’s cancer appeared to be gone – but no longer. Her tumor markers have increased, including levels of carcinoembryonic antigen (CEA), which is common to cancers of not only the breast but also the colon, rectum, prostate, ovary, lung, thyroid, and liver. Every month...

Researchers identified and synthesized a small molecule that could be a more accessible and effective alternative to an antibody that is successfully used to treat a range of cancers. A small molecule that could be a more accessible and effective alternative to an antibody that is successfully used to treat a range of cancers has been identified and synthesized by scientists at Tel Aviv University and the University of Lisbon. The results of the study were published in the Journal for ImmunoTherapy of Cancer. Behind the groundbreaking development is an international team of researchers. They were led by Prof. Ronit...

Common cold now putting people in the hospital.. Children are turning up at doctors’ clinics infected with as many as three different viruses due to their immune systems being weakened by lockdown, it has been revealed. According to Thomas Murray, an infection-control expert and associate professor of pediatrics at Yale, his team is seeing cases of children with combinations of seven common viruses, including adenovirus, rhinovirus, respiratory syncytial virus (RSV), human metapneumovirus, influenza and parainfluenza, as well as COVID-19. “That’s not typical for any time of year and certainly not typical in May and June,” said Murray. Such viruses are...

In patients with serious and long-term COVID-19, disturbed blood coagulation has often been observed. Now, researchers have discovered that the body's immune system can affect the spike protein on the surface of the SARS-CoV-2 virus, leading to the production of a misfolded spike protein called amyloid. The research team studies illnesses which are caused by misfolded proteins, of which Alzheimer's disease in the brain is the most well-known example. The researchers noted that there are many similarities between COVID-19-related symptoms and those which are observed in illnesses caused by misfolded proteins. Using computer simulation, the researchers discovered that the coronavirus'...

Antimicrobial resistance stewardship programs have to be prioritized, keeping the demands of the continuing Covid-19 pandemic in context On March 11, 2020, the World Health Organization (WHO) declared COVID-19, the disease caused by the SARS-CoV-2 virus, a pandemic. Two years later, the shadow of the Covid pandemic is still looming over us. While the world is making valiant attempts to move into the post-pandemic phase, the situation is akin to “one step forward, two-step backward”, as new variants of this virus are still emerging. Covid-19 has taken center stage in every facet of life. Policymakers and medical personnel are still...

It is well established that older adults are more susceptible to infection and their immune systems less capable of generating a strong immune response. Findings suggest that lymph nodes, which are critical for maintaining and revving up the immune response during infection, age at different rates. Lymph nodes closer to the skin deteriorate two to three times more quickly than those deeper in the body. White blood cells, specifically T cells, are the soldiers of the immune system. T cells are made by the thymus, a gland that sits below the chest bone and above the heart. The thymus quickly...

A calorie-reduced diet can not only delay the development of metabolic diseases, but also has a positive effect on the immune system. Researchers have now shown for the first time that this effect is mediated by an altered gut microbiome, which slows down the deterioration of the immune system in old age (immune senescence). Around 2 billion people worldwide are overweight. Obesity increases the risk of developing high blood pressure, heart attack or type 2 diabetes mellitus and can cause inflammation in the body that weakens the immune system through an accumulation of specific memory T and B cells. This...