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Keyword: hypocalcemia

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  • Denosumab linked to severe hypocalcemia in dialysis-dependent seniors

    01/28/2024 9:10:43 PM PST · by ConservativeMind · 4 replies
    Medical Xpress / HealthDay / JAMA ^ | Jan. 23, 2024 | Elana Gotkine / Steven T. Bird et al / Pascale Khairallah et al
    For female dialysis-dependent patients aged 65 years or older treated for osteoporosis, denosumab is associated with an increased incidence of severe or very severe hypocalcemia, according to a study. Steven T. Bird, Ph.D., Pharm.D. and colleagues examined the incidence and comparative risk for severe hypocalcemia with denosumab versus oral bisphosphonates in a retrospective cohort study involving female dialysis-dependent Medicare patients aged 65 years or older treated for osteoporosis. The main outcomes were severe hypocalcemia, defined as total albumin-corrected serum calcium <7.5 mg/dL or a primary hospital or emergency department hypocalcemia diagnosis, and very severe hypocalcemia (serum calcium <6.5 mg/dL). Overall,...