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A team of investigators report that adults who later develop cardiovascular disease show declining physical activity levels beginning roughly 12 years before their event, with the gap versus their healthy peers persisting long afterward. Scientists analyzed data from 3,068 participants in CARDIA, a prospective study initiated in 1985–1986 with up to 10 physical activity assessments through 2020–2022. Participants were followed in four US cities with a median follow-up of 34.0 years. Physical activity decreased steadily from young adulthood into middle age, then stabilized in later years across the full cohort. Black men had a more sustained decline, while Black women...

Ivermectin administered to the whole population significantly reduces malaria transmission, offering new hope in the fight against the disease. The BOHEMIA trial, the largest study on ivermectin for malaria to date, showed a 26% reduction in new malaria infection on top of existing bed nets, providing strong evidence of ivermectin's potential as a complementary tool in malaria control. Ivermectin, a drug traditionally used to treat neglected tropical diseases like onchocerciasis, which causes river blindness, and lymphatic filariasis, which causes elephantiasis, has been shown to reduce malaria transmission by killing the mosquitoes that feed on treated individuals. Given the rising resistance...

Eight essential nutrients make up the suite of B vitamins also known as the B complex. Research has revealed that these B vitamins influence a vast spectrum of human health and disease. "It's hard to study the B vitamins in isolation," says gastroenterologist Joel Mason. "Four of these B-vitamins cooperate as co-factors in many critical activities in cells in what we call 'one carbon metabolism.'" One of the most active areas for B vitamin research is cognitive health. By the age of 75–80, 40% of people have a diminished ability to absorb food-bound B12, says Mason. This deficiency leads to...

Researchers have linked brighter night-time light exposure to elevated risks of five major cardiovascular diseases. Circadian rhythms govern fluctuations in blood pressure, heart rate, platelet activation, hormone secretion, and glucose metabolism. Long-term disruption of those rhythms in animal and human studies have produced myocardial fibrosis, hypertension, inflammation, and impaired autonomic balance. Researchers conducted a prospective cohort analysis to assess whether day and night light exposure predicts incidence of cardiovascular diseases and whether relationships vary with genetic susceptibility, sex, and age. Data came from 88,905 UK Biobank participants, average age 62.4 ± 7.8 years and 56.9% female, who wore wrist-based light...

ROCHESTER, Minn. — Mayo Clinic researchers have developed a new artificial intelligence (AI) tool that helps clinicians identify brain activity patterns linked to nine types of dementia, including Alzheimer's disease, using a single, widely available scan — a transformative advance in early, accurate diagnosis. The tool, StateViewer, helped researchers identify the dementia type in 88% of cases, according to research published online on June 27, 2025, in Neurology, the medical journal of the American Academy of Neurology. It also enabled clinicians to interpret brain scans nearly twice as fast and with up to three times greater accuracy than standard workflows....

Statistics show that men who have sex with men— whether they identify as gay, bisexual, or other— have a higher risk of contracting an STD than any demographic, but many factors other than the specifics of how sex goes down in the bedroom contribute to this increased risk. Economic and societal factors such as income, the effects of emotional support on risk-taking, and the power and privilege structures of society have all been found to play a role in the likelihood of succumbing to an STD, especially HIV. Approximately 4.1 percent of Americans identify as gay, bisexual, or other, according...

A US tourist was arrested for entering North Sentinel Island, where the inhabitants shun all contact with the outside world. The tourist had carried a coconut and Diet Coke as a "gift" for the Sentinelese people. An American tourist was arrested for entering a restricted island with an isolated tribe carrying a can of Diet Coke and a coconut, Indian police said on Thursday. The 24-year-old man entered North Sentinel Island, part of the Andaman and Nicobar Islands off India's southeastern coast. He wanted to meet the Sentinelese people, who are untouched by the modern world. Numbering around 150, the...

The world’s first vaccine against gonorrhoea is set to be rolled out in the UK amid a surge in cases of the sexually transmitted infection. Initially the vaccine will not be available to everyone, with a focus on vaccinating gay and bisexual men with a history of multiple sexual partners or an STI. 85,000 cases of gonorrhoea were reported in 2023, the highest number since records began in the year 1918. The rollout of the vaccine is due to begin in August by NHS England, with NHS Scotland also looking into a similar rollout. Though the vaccine is understood to...

Alan Jackson got choked up on stage.May 17 marked Alan Jackson's last stop on his current tour — which is going to be his last. Y'all may have heard that I'm kinda winding down, and in fact this is my last road show of my career," Jackson, 66, said in front of a roaring Milwaukee crowd. "Y'all gonna make me tear up out here. But I will say, this is my last road show out here, but we're planning on doing a big finale show in Nashville next summer sometime. It just felt like I had to end it all...

-Local farmers report huge financial losses as many yaks in the area have fallen ill -GB authorities say veterinary team has been sent with medicines to treat the animals Over 100 yaks have been killed after a mysterious disease broke out in the high-altitude pasture of Shimshal Pamir, local residents said on Wednesday, as officials confirmed the situation and said a medical team had been dispatched for rescue. Located at 3,100 meters above sea level, Shimshal is the highest settlement in Pakistan’s northern Hunza region and the last village before the country’s border with China. “A disease broke out in...

Scientists have discovered a surprising new connection between gut health and blood cancer risk—one that could transform how we think about aging, inflammation, and the early stages of leukemia. As we grow older—or in some cases, when gut health is compromised by disease—changes in the intestinal lining allow certain bacteria to leak their byproducts into the bloodstream. One such molecule, produced by specific bacteria, acts as a signal that accelerates the expansion of dormant, pre-leukemic blood cells. The study suggests that this mechanism may reach beyond leukemia to influence risk for other diseases and among older people who share a...

[MULTIPLE VIDEO EXCERPTS AT LINK] This story originally appeared on vigilantfox.com and was republished with permission. RFK Jr. is perhaps the most impactful HHS Secretary we’ve ever seen—but if you read the mainstream news, you’d think his first 100 days were a disaster. While chronic disease drains trillions from Americans every year, the press can’t stop obsessing over measles. Just look at these headlines: “As measles cases rise, some parents become vaccine enthusiasts.” “US measles cases near 900, outbreaks reported in 10 states.” “Measles may be making a comeback in the U.S., Stanford Medicine experts warn.” It makes you think...

In a nutshell One dose of a psychedelic compound (25CN-NBOH) significantly improved cognitive flexibility in mice, even 2 to 3 weeks after the drug was administered. Treated mice adapted better to new learning rules in a reversal task, showing stronger performance across multiple behavioral measures compared to controls. These long-lasting effects suggest psychedelics may promote meaningful, enduring changes in brain plasticity, offering potential new approaches for treating conditions like depression, PTSD, and Alzheimer’s disease. ANN ARBOR, Mich. — A single dose of a psychedelic compound could be key to helping your brain become more adaptable for weeks. University of Michigan...

A new type of antibiotic for treatment of urinary tract infections in women could also work against gonorrhea infections, a new study finds. This could put the medication, called gepotidacin, on track to become the first new antibiotic for gonorrhea since the 1990s. “Gepotidacin is a novel oral antibacterial treatment with the potential to become an alternative option for the treatment of gonococcal infections, supported by an acceptable safety and tolerability profile,” the researchers wrote in the study published Monday in The Lancet, adding that the drug “could mark a meaningful advancement in patient care.” As an antibiotic, gepotidacin works...

Texas administered 15,000 more measles vaccinations this year compared to 2024—and now there’s a growing measles outbreak that has surpassed the total number of cases reported across the entire United States last year.The news follows this website’s February report that measles cases in Gaines County, Texas, had jumped 242% following a health district campaign to hand out free measles vaccines.A measles outbreak after higher vaccination rates in Texas calls into question the shot’s claimed effectiveness and underlying design.Timeline & NumbersBetween January 1 and March 16 last year, 158,000 measles vaccines were administered in the state, according to CBS News.During the...

"One way to stop the spread of diseases transmitted by insects is to make the blood of animals and humans toxic," according to researchers. Researchers have discovered that a medication typically prescribed for rare diseases could make human blood deadly for mosquitoes, offering a potential lead to curb diseases such as malaria. They experimented with a drug called nitisinone, which is usually prescribed to individuals with rare inherited diseases that typically prevent them from being able to fully break down certain amino acids. The medication works by blocking an enzyme to prevent the build-up of harmful disease byproducts in the...

Certain vaccinations are important for pets to protect them from several fatal diseases. However, while this process is important, pet owners should be careful to make sure they are not over-vaccinating their animal companions because this can lead to health issues. Over-vaccination in pets is when a pet is inoculated with the same vaccines multiple times. When this happens, it can result in adverse effects on your pet's health. This can be dangerous to some animals because they are vaccinated too frequently for their bodies to handle. Studies show that over-vaccination can cause hypersensitivity reactions and autoimmune diseases. Over-vaccination is...

A research team has discovered that C-reactive protein (CRP) can exacerbate kidney inflammation caused by diabetes, also known as diabetic kidney disease (DKD), through a Smad3-NLRP3 inflammasome-dependent mechanism. Therefore, future research targeting CRP or the Smad3-NLRP3 mechanism may provide new treatment directions for DKD. CRP is an inflammatory protein whose level rises rapidly when the body undergoes an inflammatory response, making it a commonly used clinical marker for inflammation. Recent studies have shown that CRP exacerbates kidney inflammation and fibrosis through the TGF-β/Smad3 signaling pathway, worsening DKD. The activation of the NLRP3 inflammasome is a key factor driving kidney inflammation,...

Researchers have identified BbLDH as a critical enzyme for B. burgdorferi survival, paving the way for targeted Lyme disease treatments. New inhibitors could halt the bacteria without affecting other organisms, making this a major step forward. =============================================================================== A team of scientists has zeroed in on an enzyme that could revolutionize Lyme disease treatment. By uncovering the crucial role of BbLDH in bacterial survival and infectivity, they’ve opened the door to highly targeted therapeutics. Their findings even hint at broader applications for fighting other tick-borne diseases. A Promising New Target for Lyme Disease Treatment Scientists have identified an enzyme that could...

“The Brady Bunch” is back in the news after 50 years, thanks to anti-vaccination activists who are using a 1969 episode of the family sitcom to back up their case that, as diseases go, you “sure can’t beat the measles.” And Marcia Brady herself, Maureen McCormick, is not happy about it The episode called “Is There a Doctor in the House?” finds the Brady children sick with the measles and staying home from school. “If you have to get sick, sure can’t beat the measles,” Marcia says. The kids are thrilled they didn’t have to take medicine, and Jan is...