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Researchers conducted a large-scale epidemiological study to explore the potential health benefits of high muscle strength in preventing type 2 diabetes (T2D) across varying levels of genetic risk. The study found that higher muscle strength was associated with over 40% lower risk of T2D, regardless of genetic susceptibility to T2D. The study highlights the importance of maintaining or improving muscle strength for preventing T2D. The research utilized data of 141,848 white British individuals without baseline T2D from the UK Biobank. Muscle strength was assessed in the form of grip strength. Genetic risk of T2D was estimated based on 138 known...

A research team has discovered that C-reactive protein (CRP) can exacerbate kidney inflammation caused by diabetes, also known as diabetic kidney disease (DKD), through a Smad3-NLRP3 inflammasome-dependent mechanism. Therefore, future research targeting CRP or the Smad3-NLRP3 mechanism may provide new treatment directions for DKD. CRP is an inflammatory protein whose level rises rapidly when the body undergoes an inflammatory response, making it a commonly used clinical marker for inflammation. Recent studies have shown that CRP exacerbates kidney inflammation and fibrosis through the TGF-β/Smad3 signaling pathway, worsening DKD. The activation of the NLRP3 inflammasome is a key factor driving kidney inflammation,...

Micronutrient deficiency, whereby levels of vitamins and minerals essential for healthy bodily function are far too low, is common in people with type 2 diabetes, finds a pooled data analysis of the available evidence. A lack of vitamin D is the most common "missing" micronutrient. Genetic predisposition, various environmental factors, sedentary lifestyle, an unhealthy diet and obesity are risk factors for the disease, explain the researchers. And previously published research suggests that micronutrients have a key role in the development of type 2 diabetes, by potentially affecting glucose metabolism and insulin signaling pathways. Their analysis included 132 studies, involving 52,501...

In patients with diabetes and established diabetic retinopathy (DR), treatment with glucagon-like peptide 1 receptor agonists (GLP1RAs) is associated with increased risks of DR progression compared with sodium-glucose cotransporter 2 inhibitors (SGLT2is), according to a study. Donna Shu-Han Lin, M.D. and colleagues examined the effects of GLP1RAs and SGLT2is on the development or progression of DR. Analysis included 1,517 patients treated with a GLP1RA with DR and 9,549 without DR and 3,034 patients treated with an SGLT2i with DR and 19,098 without DR. The researchers found that in patients with preexisting DR, the incidence of any DR progression event was...

An international academic consortium has identified 13 biomarkers that significantly improve the ability to accurately predict cardiovascular disease risk in people with type 2 diabetes. The analysis, conducted by 23 experts from 11 countries, was led by The Johns Hopkins University in the United States, the Chinese University of Hong Kong in Hong Kong, and Lund University in Sweden. Although people with type 2 diabetes are two times more likely to develop cardiovascular disease than those without diabetes, it is a challenge for clinicians to predict who in this population is most at risk. Traditional risk scores, which reflect risk...

Research has revealed how, in diabetics, high levels of blood sugar disrupt the function of key cell subsets in the lungs that regulate the immune response. It also identifies a potential strategy for reversing this susceptibility and saving lives. Prof. Eran Elinav's team subjected multiple mouse models of types 1 and 2 diabetes to a variety of viral lung infections. The immune reaction, which in nondiabetics eliminates the infection and drives tissue healing, was severely impaired in the diabetic mice, leading to uncontrolled infection, lung damage and eventual death. "High blood sugar levels severely disrupt certain subsets of dendritic cells...

Treating newly diagnosed type 1 diabetes patients with semaglutide (trade names Ozempic, Wegovy and Rybelsus) may drastically reduce or even eliminate their need for injected insulin. Those are the remarkable findings of a small study. "Our findings from this admittedly small study are, nevertheless, so promising for newly diagnosed type 1 diabetes patients that we are now absolutely focused on pursuing a larger study for a longer period of time," says Paresh Dandona, MD, Ph.D. A total of 10 patients were studied, all of whom had been diagnosed in the past three to six months with type 1 diabetes. The...

<p>University of Colorado head football coach and NFL Hall of Famer Deion Sanders, who has previously had two toes amputated, now faces the risk of losing his left foot due to ongoing blood circulation issues.</p><p>"I don't have feeling in the bottom of my foot at all," the former NFL star and Hall of Famer told his medical team, in a filmed meeting posted on Youtube for "Thee Pregame show."</p>

When a child with diabetic ketoacidosis (DKA) requires intensive care, clinicians often monitor blood ketone levels to determine whether treatment has successfully reversed the abnormal ketone production. Yet, the utility of blood ketone levels to diagnose DKA or determine whether a child's DKA has resolved have not been rigorously studied. Elise Tremblay, MD shows that a particular value of plasma beta-hydroxybutyrate (BOHB) can signal that DKA has clinically resolved and intensive treatment can stop. Widespread adoption of this defined endpoint could remove some of the uncertainty from monitoring DKA. It could potentially end intensive care at the right time—instead of...

NATIONAL KETO DAY National Keto Day hits January 5th with an approach to transforming our health. Recent research suggests the high-fat, low-carb ketogenic or ‘keto’ diet offers a number of benefits. #NationalKetoDay Benefits Two of the most significant perks seen with the keto diet are weight loss and healthy blood sugar support. In fact, studies have shown improved glycemic control for those with type 2 diabetes while adhering to a ketogenic diet. Other health benefits of a keto diet may include healthy cholesterol and blood pressure support. It may also be beneficial for those with Alzheimer’s and Parkinson’s diseases. Keto...

A trial of persons with type 2 diabetes found a low-carbohydrate, high-fat, calorie unrestricted diet helped patients achieve better weight loss and glucose control over a 6-month intervention compared to a high-carb, low-fat diet. The changes were not sustained 3 months after, suggesting a need for long-term dietary changes to maintain meaningful health benefits. More than half of persons with diabetes also have nonalcoholic fatty liver disease (NAFLD). Prior studies suggest that weight loss improves both diabetes control and NAFLD and restriction of carbohydrate intake improves the control of blood sugar. Researchers assigned 165 persons with type 2 diabetes to...

Clinical trial results suggest that a specific step strategy, in which patients with diabetic macular edema start with a less expensive medicine and switch to a more expensive medicine if vision does not improve sufficiently, gives results similar to starting off with the higher-priced drug. The main complication of diabetic macular edema, fluid build-up in the retina that causes vision loss, is commonly treated with anti-vascular endothelial growth factor (VEGF) drugs. Results of the trial, which examined a stepped regimen of anti-VEFG drugs Avastin (bevacizumab) and Eylea (aflibercept), were published today. "Our study showed that switching treatments when needed is...

Marcus Lamb, a co-founder and the CEO of the conservative Christian Daystar Television Network who vocally opposed Covid-19 vaccines, has died at 64, weeks after he contracted Covid-19, the network said.

Drugs and syringes have become such a problem in Starbucks bathrooms that the company is installing needle-disposal boxes in certain locations Starbucks is installing boxes for safe disposal of syringes in the bathrooms of certain locations, following workers' reports of discarded needles and sometimes concerning conditions. The coffee giant is exploring remedies after employees expressed fears about being pricked by uncapped needles and experiencing related health risks. Starbucks is testing solutions, including installing sharps-disposal boxes, using heavier-duty trash bags to prevent needle pokes, and removing trash cans from certain bathrooms.

The 51-year-old mother of five is in kidney failure, a result of her Type 2 diabetes. Lucia (whose last name has been withheld at her request because of her family’s immigration status) is one of an estimated 6,500 undocumented immigrants in the United States who are living with end-stage renal disease, She feels grateful for the limited care she receives here in the United States, because she is acutely aware of the reality that she would not be entitled to any care in her native Mexico and would almost certainly have died by now.

The results, published in The Lancet Diabetes and Endocrinology, showed the patients could be separated into five distinct clusters. Cluster 1 - severe autoimmune diabetes is broadly the same as the classical type 1 - it hit people when they were young, seemingly healthy and an immune disease left them unable to produce insulin Cluster 2 - severe insulin-deficient diabetes patients initially looked very similar to those in cluster 1 - they were young, had a healthy weight and struggled to make insulin, but the immune system was not at fault Cluster 3 - severe insulin-resistant diabetes patients were generally...

Paramedics were called to the Washington home of Justice Sonia Sotomayor Friday morning, but a Supreme Court spokeswoman said the justice was not hospitalized and went to work Friday after being treated for low blood sugar. "She experienced symptoms of low blood sugar at her home this morning. She was treated by emergency medical services and is doing fine," court spokeswoman Kathy Arberg told POLITICO. "She's at work and following her usual schedule and will be participating in all planned activities over the weekend." The episode caused concern to some neighbors of the 63-year-old justice, who lives in an apartment...

New Inhaled Insulin Drug Helps People With Diabetes PHILADELPHIA (CBS) — National Diabetes Month is observed every November so individuals, health care professionals, organizations, and communities across the country can bring attention to diabetes and its impact on millions of Americans. More than 400 million adults were living with diabetes in 2015 and this number is expected to increase to around 642 million or one in ten adults by 2040. One in two adults with diabetes is undiagnosed. Daniele Hargendader makes sure to stay fit as a personal trainer. She often works out in Pennypack Park. Daniele also has Type...

Hoping to appeal to millions of needle-phobic Americans with diabetes, drugmakers Sanofi and Mannkind have just launched Afrezza, an insulin that's inhaled, rather than injected. Afrezza was approved by the Food and Drug Administration last June for patients with either Type 1 or 2 diabetes, to be used along with other medicines, diet and exercise. Paris-based Sanofi SA, a major player in the huge diabetes treatment market, then licensed Afrezza's worldwide marketing rights from Mannkind Corp. of Valencia, California, which developed Afrezza.

Jack Lamar Roberson was shot and killed by police in his home on Friday afternoon in Waycross, Georgia. According to local TV station First Coast News, his fiancée Alcia Herron called 911 for an ambulance after becoming worried about diabetes medication Roberson had taken. Cops claim Roberson was brandishing two weapons (not identified by police, though the mayor said he was told it was a knife) and came toward them “aggressively armed”. Police also say they were informed Roberson had attempted to commit suicide and was being combative while on their way to his residence. His mother and his fiancée...