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As we age, blood stem cells, the essential source of new blood cells in the body, can accumulate genetic mutations. Now, scientists have not only discovered the mechanism that fuels their unchecked growth but have also found a way to stop it. The study reveals that a common aging-associated mutation in the gene Dnmt3a boosts the power-generating function of mitochondria in blood stem cells. This mutation allows the cells to make copies of themselves more readily than normal and creates fertile ground for the development of clonal hematopoiesis, a condition that dramatically increases the risk of heart disease, blood cancers,...

"One way to stop the spread of diseases transmitted by insects is to make the blood of animals and humans toxic," according to researchers. Researchers have discovered that a medication typically prescribed for rare diseases could make human blood deadly for mosquitoes, offering a potential lead to curb diseases such as malaria. They experimented with a drug called nitisinone, which is usually prescribed to individuals with rare inherited diseases that typically prevent them from being able to fully break down certain amino acids. The medication works by blocking an enzyme to prevent the build-up of harmful disease byproducts in the...

It’s in his blood. Violent crime runs in the family of the 14-year-old Newark boy charged with gunning down Detective Joseph Azcona in a flurry of bullets earlier this month, sources and the boy’s own relatives told The Post this week. The unidentified teen’s mom, Rabiyah Sorey, 43, has been a known drug dealer on her block of North Ninth Street for years, the source said. Her twin sister, Hadiyah Sorey, 43, is her “partner in crime” and runs the family business with her, the source added. “That’s a really, really bad family,” the source said. “They’ve all been arrested...

Research has found that inadequate sleep duration and late sleep onset are associated with increased glycemic variability in adults. Blood sugar regulation plays a critical role in metabolic health, with fluctuations in glucose levels linked to diabetes complications. Previous research has identified insufficient sleep as a risk factor for impaired glucose metabolism. In the study, researchers conducted a prospective cohort study to evaluate the relationship between long-term sleep duration and onset timing with glycemic variability. The study analyzed 1,156 participants, aged 46 to 83, from the Guangzhou Nutrition and Health Study. Participants underwent self-reported sleep assessments across multiple visits and...

Humans and mice exposed to long-wavelength red light had lower rates of blood clots that can cause heart attacks, lung damage and strokes, according to research led by surgeon-scientists. The team exposed mice to 12 hours of either red, blue or white light, followed by 12 hours of darkness, in a 72-hour cycle. They then looked for differences in blood clots between the groups. The mice exposed to red light had nearly five times fewer clots than the mice exposed to blue or white light. Activity, sleep, eating, weight and body temperature remained the same between the groups. The team...

A study by MSK found that a high-fiber, plant-based diet may delay progression to multiple myeloma in at-risk individuals. Researchers at Memorial Sloan Kettering Cancer Center (MSK) have announced results from the first clinical trial to demonstrate that a high-fiber, plant-based dietary intervention may delay the progression to multiple myeloma—a rare and currently incurable blood cancer that affects the bone marrow. The study involved 20 participants diagnosed with a precancerous blood disorder and an elevated body mass index (BMI), placing them at higher risk for developing multiple myeloma. Over 12 weeks, participants followed a high-fiber, plant-based meal plan and received...

Researchers have reported results from the first-ever clinical trial demonstrating that a high-fiber, plant-based dietary intervention may delay progression to multiple myeloma, a rare and incurable blood cancer affecting the bone marrow. The study enrolled 20 participants with a precancerous blood disorder and an elevated body mass index (BMI) at risk of developing multiple myeloma. They received 12 weeks of high fiber plant-based meals and 24 weeks of coaching. Two participants with progressing disease prior to the study showed a significant improvement of their disease progression trajectory. Additionally, at one year after enrollment, none of the participants had progressed to...

Insulin resistance may not be on your radar, but it should be. This often-overlooked condition is a precursor to a host of metabolic conditions, especially prediabetes and diabetes.1 ,2 The good news is there are ways to protect against and even reverse insulin resistance. That’s important because cells rely on insulin all day, every day, to effectively use glucose for fuel. Plus, it can reduce your long-term risk of many chronic illnesses. How can you protect against insulin resistance? Read on to learn all about insulin resistance, how it impacts your blood sugar levels, and the best ways to naturally...

Commonly prescribed drugs used to treat high blood pressure have been shown to, over time, wreck the kidneys' ability to filter and purify blood, but exactly how that dangerous side effect unfolded has been a riddle. Researchers say they've solved the mystery. Researchers found that the drugs essentially rewire the kidneys to do something other than the important work of filtering blood. The kidneys start producing more of a hormone called renin; nerve endings grow excessively; cells lining the kidneys' tiny blood vessels get too large; scars form and spread; and inflammation sets in, which "can take a terrible toll...

On May 10, the Canadian Blood Services (CBS) issued an apology to 2SLGBTQIA+ communities for the role its former donor eligibility policy played in contributing to “discrimination, homophobia, transphobia, and HIV stigma within society.” From 1998 until 2013, CBS had a lifetime blood donation ban for any man who had sex with another man, even once. This ban then became a deferral period of five years, then 12 months, and finally, three months. Under their most recent screening policies updated in late 2022, both CBS and Héma-Québec ask every potential donor if they have had anal sex with a new...

When a pregnant woman had her blood sampled back in 1972, doctors discovered it was mysteriously missing a surface molecule found on all other known red blood cells at the time. After 50 years, this strange molecular absence finally led researchers from the UK and Israel to describe a new blood group system in humans. "It represents a huge achievement, and the culmination of a long team effort, to finally establish this new blood group system and be able to offer the best care to rare, but important, patients," UK National Health Service hematologist Louise Tilley says, after nearly 20...

People with higher levels of metals found in their blood and urine may be more likely to be diagnosed with—and die from—amyotrophic lateral sclerosis, or ALS, a study suggests. Researchers have known that ALS, a rare but fatal neurodegenerative condition, is influenced by genetic and environmental factors, including exposure to pesticides and metals. This latest study examined the levels of metals in the blood and urine of people with and without ALS, finding that exposure to individual metals and mixtures of metals is associated with a greater risk for ALS and shorter survival. Goutman's team measured metal levels in plasma...

(CNN) — Consuming a drink with erythritol — an artificial sweetener used to add bulk to stevia and monk fruit and to sweeten low-carb keto products — more than doubled the risk of blood clotting in 10 healthy people, according to a new pilot study. Clots can break off blood vessels and travel to the heart, triggering a heart attack, or to the brain, triggering a stroke. Previous research has linked erythritol to a higher risk of stroke, heart attack and death. “What is remarkable is that in every single subject, every measure of platelet responsiveness (clotting) went up following...

The smartest people I know are Freepers. Hopefully, y’all can give me some advice My 72yo wife has ulcerative colitis (UC), she’s in her 6th month of trying to get it into remission. UC is bleeding ulcers in your colon – therefore rectal bleeding and diarrhea, poor girl has it hugely. Her last UC episode, which went into remission within a couple months, was 17 year ago when she was 55yo. She’s taken all her biologic initial dosages of Remicade. We have Medicare and Medigap insurance, we live in KY in a major metro area. Her blood test results are...

The results of routine blood tests could be used to speed up cancer diagnosis among people with stomach pain or bloating, suggests a study. The study looked at data from more than 400,000 people aged 30 or older in the UK who had visited a GP due to stomach pain and more than 50,000 who had visited their GP due to bloating. Two thirds of this group had blood tests following their appointment. In the new study, the researchers found that people aged 60 or over who had gone to the GP with either stomach pain or bloating had a...

ay receive blood transfusions from a donor with O-negative blood, sometimes referred to as the "universal donor" type of blood. "An AB patient may receive enough O blood units during a transfusion that nearly all of their red cells type as group O," Our Blood Institute explains. "Within a few months, the patient’s bone marrow should naturally replace the transfused blood with his or her original blood type." This brings us neatly to bone marrow transplants. Red blood cells are made in your bone marrow, and if you receive a bone marrow transplant from a donor of a different type,...

The headquarters of the Republican National Committee was put on lockdown Wednesday morning after two vials of blood were discovered in a package addressed to former President Donald Trump — with the party’s chairman calling the incident a “biological attack.” “Today, vials of blood were sent to RNC Headquarters in DC. We are thankful to law enforcement, who responded quickly and ensured everyone’s safety. The lockdown has been cleared and staff has resumed their office duties because we remain unintimidated and undeterred in our efforts to elect President Trump to the White House,” RNC boss Michael Whatley said in a...

The headquarters of the Republican National Committee was briefly placed on lockdown Wednesday morning and the hazardous materials team from the United States Capitol Police responded to the scene on Capitol Hill. According to sources reported by NBC News, the emergency response stemmed from a package containing vials of blood that was sent to the RNC's offices just a few steps from House office buildings.NEW: Three sources tell @NBCNews vials of blood were sent to the RNC... https://t.co/iRhiH2O1rK— Dasha Burns (@DashaBurns) May 22, 2024Capitol Police told NBC News that the package was contained and removed by its personnel while another...

The headquarters of the Republican National Committee were put on lockdown Wednesday morning. It was unclear exactly what caused the security alert, but one source told The Post: “It sounds like vials of blood were sent in a package and something broke open.” There were no immediate reports of any injuries. A Hazmat unit was on site at the Capitol Hill building.

... In the early 1980s, the UK could not keep up with demand for Factor VIII, which was made by pooling - or mixing - the blood plasma of thousands of individual donors. Instead the treatment was shipped from the US. In the UK, blood donations have always been voluntary, but in the US, drug companies were allowed to pay cash for plasma. High risk groups, from prisoners to drug users, had a clear financial incentive to give blood and potentially lie about their medical history. Evidence uncovered by campaigners and seen by the ongoing public inquiry into the wider...