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Cancer is a disease driven by gene mutations. These mutated genes in cancer fall into two major categories: tumor suppressors and oncogenes. Researchers studying mutations in tumor suppressor genes have dedicated significant focus to p53, the most frequently mutated tumor suppressor gene in human cancers. However, while research has shown that these therapies are effective at inducing p53 activity, they generally can't kill cancer cells. New research illuminates the mechanisms at work that prevent p53 activation from triggering effective cancer cell death. They show that inhibiting two distinct repressors of p53 can elicit cancer cell death through activation of a...

The truth behind the casualty figures and more...

The Wisconsin woman accused of decapitating her lover during a wild meth-fueled escapade last year randomly attacked her own lawyer in the courtroom Tuesday — striking him in the head. Taylor Schabusiness, 25, lunged at defense attorney Quinn Jolly after the judge in the gruesome murder case suggested pushing the trial back two months. Shocking video of the spontaneous and violent outburst shows Schabusiness calmly sitting in the Green Bay courtroom as Judge Thomas J. Walsh recommends starting the murder trial on May 15 instead of March 6 — a suggestion he made at Jolly’s request. Seemingly angered by the...

Justice Department prosecutors investigating the mishandling of classified documents at Donald Trump’s Florida estate are seeking to pierce the attorney-client privilege and want to again question one of the former president’s lawyers before a grand jury, a person familiar with the matter said Tuesday night. The privilege protects lawyers from having to tell prosecutors about confidential conversations their clients have with them. But prosecutors can get around that privilege if they can convince a judge that the communications they want information about were made in furtherance of a crime — a principle known as the crime-fraud exception. Prosecutors have already...

Nature Magazine reported Tuesday that the second phase of the World Health Organization’s (WHO) COVID origins report has been “quietly shelved…citing ongoing challenges over attempts to conduct crucial studies in China.”This second phase was announced in August 2021, after WHO officials finally admitted problems with the first report, which was released in March 2021. That delegation, led by EcoHealth Alliance’s Dr. Peter Daszak (before we knew just how much involvement he had in the weaponization of coronaviruses) released a report stating that it was “extremely unlikely” that COVID-19 originated in a lab. That report was considered in the media as...

Several breakfast staples saw sharp price increases due to a perfect storm of bad weather and disease outbreaks—and continued effects from Russia’s invasion of Ukraine. Egg prices increased 8.5% in January from a month earlier and are up 70.1% over the past year, the highest annual rate since 1973. The deadliest avian-influenza outbreak on record has devastated poultry flocks across the U.S., leading the price of eggs to rise more than any other grocery item in 2022, according to Information Resources Inc. U.S. egg inventories were 29% lower in the final week of December 2022 than at the beginning of...

A STATEMENT BY PRESIDENT DONALD J. TRUMP ON THE WITCH HUNT OF JANUARY 6th Recently, it was shockingly revealed that Twitter colluded with the FBI and other law enforcement agencies to Rig and Steal the 2020 Presidential Election in favor of Joe Biden, and to deplatform and illegally censor me. As a key example of the corruption within the FBI, Special Agent Charles McGonigal, the head of the now fully “debunked” Russia, Russia, Russia Hoax, has recently been arrested for being “paid off” by receiving large amounts of money from, get this, Russia. The Russia Witch Hunt was extremely detrimental...

Journalist Soledad O’Brien alerted reporters on Monday that the term “woke” has now become akin to a “racist slur” or “the n-word.” From her Twitter account, the ex-CNN anchor posted an image of a tweet from Rep. Marjorie Taylor Greene, R-Ga., commenting on the Super Bowl pregame show. Greene wrote, “Chris Stapleton just sang the most beautiful national anthem at the Super Bowl. But we could have gone without the rest of the wokeness.” O’Brien tweeted in response, “So reporters… for many people, ‘woke’ means (b)lack people. Or more likely—a racist slur. So maybe do a better job in interviews...

https://howiecarrshow.com/donald-trump-nikki-haley-bill-barr-and-the-balloon-the-howie-carr-show-2-14-23-hour-2/ 15 min President Donald J. Trump joins Howie to discuss our declining national security from the Mexican border to the unidentified aircraft in our atmosphere. The former president discusses the atrocities that have occurred against the American people since January 6 and censorship from Twitter to AT&T. Tune in for Trump’s takes on Elon Musk, Bill Barr, and Nikki Haley! Howie Carr, Boston station

(LifeSiteNews) — Today’s episode of The John-Henry Westen Show comes at you from Kampala, Uganda, where I had the privilege of interviewing Archbishop Paul Ssemogerere. (Stay tuned the rest of this week, as we have more content from our African trip lined up as well In this episode, Archbishop Ssemogerere shares his thoughts about the massive outside pressure from other nations, and even Pope Francis himself, to get African countries like Uganda to decriminalize sodomy. His Excellency says bishops in Uganda are very much aware of the outside pressure to conform to LGBT ideology and have been discussing ways to...

Society self-destructs while playing pretend.Vladimir Legoyda, the official spokesman for the Russian Orthodox Church and the Patriarch, recently spoke on the Radio Vera program “Bright Evening” about, how a society handles gender issues can provide a window into the state of that society, suggesting that the viability of the society itself can be measured by its reaction to the gender issue. Legoyda went on to explain how the fact that Western society seriously entertains the idea of more than two genders, suggests that it is suffering from a serious, life threatening disease, arguing that such a society must "come to...

You stumble across them everywhere, in villages and cities, in the smartest neighbourhoods and the most run down. They lurk behind overgrown gardens, decaying beneath veils of moss and ivy. Crows and raccoon dogs make their homes in them; little children peer through their gates and imagine ghosts. They are the “witch houses” of Japan — mysterious tokens of social decay in one of the wealthiest societies in the world. Called akiya, or abandoned homes, they have spread like mould in the past few years. The last time the government made a count, five years ago, it found 8.5 million...

CNA Newsroom, Feb 7, 2023 / 14:50 pm In a new attack on the Catholic Church, the Nicaraguan dictatorship led by President Daniel Ortega and his wife, Vice President Rosario Murillo, sentenced three priests, a deacon, two seminarians, and a layman from the Diocese of Matagalpa to 10 years in prison. According to reports from the local newspaper La Prensa and the Nicaraguan Center for Human Rights (CENIDH), the sentence was issued on Feb. 6 by Judge Nadia Tardencilla of the Second Criminal Trial District. The sentence consists of five years for the crime of “conspiracy to undermine national security...

A majority of members in the ruling Liberal Democratic Party are opposed to the legalization of same-sex marriageJapanese Prime Minister Fumio Kishida dismissed a close aide following media reports accusing him of making derogatory remarks against sexual minorities. Masayoshi Arai who served as an executive secretary to Kishida had given out off-the-record comments to the press on Feb. 3 highlighting his reluctance to “not even want to look at” sexual minorities, The Asahi Shimbun reported on Feb. 4. Kishida told the press that Arai’s statements were absolutely against his government’s stance for an inclusive Japanese society. “My administration has made...

Columbia University received backlash online after a resurfaced video showed medical students reciting a revised version of the Hippocratic Oath that included tenets of critical race theory. The video, posted by nonprofit Mythinformed Milwaukee, shows the Vagelos College of Physicians and Surgeons Class of 2025 during a White Coat Ceremony reciting an oath led by Lisa Mellman, M.D., a senior associate dean for student affairs and the Samuel Rudin professor of psychiatry. According to a news release on the Columbia University Irving Medical Center website, the August 2021 ceremony was the first time in the medical school’s 255-year history that...

I’m so pleased to share that The Climate Book is now available in the USA and Canada! I have gathered the wisdom of over one hundred contributors to highlight the many different crises we face and equip us with the knowledge we need to avoid a climate disaster. 1/2 pic.twitter.com/z2AD32Oac1— Greta Thunberg (@GretaThunberg) February 14, 2023This is the biggest story in the world, and it must be spoken as far and wide as our voices can carry and much further still. Thank you for your support!I will not earn money from this book as my copyright belongs to the Greta...

The shift to remote work is costing New York City more than $12 billion each year. Office workers are spending $4,661 less per person in the areas near their offices than before the pandemic began, according to a Bloomberg analysis of a Feb. 12 WFH Research study. The Big Apple has seen the largest reduction in spending across the country, with a deficit of $12.4 billion a year. "Less spending by workers in the central areas means a lot less sales tax revenue," Jose Maria Barrero, a professor at Mexico’s Instituto Tecnologico Autonomo and a member of the WFH Research...

Rep. Greg Stuebe seeks to prove that being a citizen requires more than just showing up. On Friday, the Sarasota Republican announced that he had introduced a bill to repeal certain provisions of the 1993 National Voter Registration Act, more commonly known as the “Motor Voter” law.

Explanation: Is the heart and soul of our Galaxy located in Cassiopeia? Possibly not, but that is where two bright emission nebulas nicknamed Heart and Soul can be found. The Heart Nebula, officially dubbed IC 1805 and visible in the featured image on the upper right, has a shape reminiscent of a classical heart symbol. The shape is perhaps fitting for Valentine's Day. The Soul Nebula is officially designated IC 1871 and is visible on the lower left. Both nebulas shine brightly in the red light of energized hydrogen, one of three colors shown in this three-color montage. Light takes...

A New York state appeals court on Tuesday upheld an order finding Donald Trump in civil contempt for having failed to comply with a subpoena from New York Attorney General Letitia James in her probe of his business practices. In a 5-0 decision, the Appellate Division in Manhattan said James had established by "clear and convincing evidence" that Trump's response to the Dec. 1, 2021, subpoena was inadequate. The court said Trump's claim that a diligent search had failed to uncover relevant documents in his possession, without explaining what steps were taken to ensure nothing would be lost or discarded,...