Amazon stocks it. Natural Grocers has it stocked at a broccoli derived supplement. I misspelled it in my post. Sulforaphane is the correct name.
Posted on 02/14/2023 8:59:57 PM PST by ConservativeMind
Cancer is a disease driven by gene mutations. These mutated genes in cancer fall into two major categories: tumor suppressors and oncogenes.
Researchers studying mutations in tumor suppressor genes have dedicated significant focus to p53, the most frequently mutated tumor suppressor gene in human cancers.
However, while research has shown that these therapies are effective at inducing p53 activity, they generally can't kill cancer cells.
New research illuminates the mechanisms at work that prevent p53 activation from triggering effective cancer cell death. They show that inhibiting two distinct repressors of p53 can elicit cancer cell death through activation of a complementary gene network known as the Integrated Stress Response.
Zdenek Andrysik, Ph.D. has worked to understand MDM2 and PPM1D, two proteins that repress p53 inside tumor cells.
"It was already established that MDM2 is a major repressor and PPM1D is a minor one," Espinosa explains. "For a long time, the hope was that inhibiting just the major repressor would suffice, but these drugs performed poorly in clinical trials."
Researchers then turned to minor repressors, including PPM1D. "A lot less is known about PPM1D and other minor repressors of p53," Andrysik says, "but it soon became clear that if you inhibit both MDM2 and PPM1D, p53 can effectively induce cancer cell death. However, the underlying mechanisms driving this synergy were unknown".
Inhibiting MDM2 and PPM1D, and thus allowing p53 to partner with ATF4 in taking cancer cells to death, has shown promise for multiple cancer types in the laboratory, Andrysik says. This revealed additional pharmacological strategies to induce cancer cell death.
For example, Andrysik and Espinosa repurposed the drug Nelfinavir, which originally was approved as an HIV therapy. "Now we know that Nelfinavir activates the Integrated Stress Response, thus becoming a great combination with MDM2 inhibitors," Espinosa says.
(Excerpt) Read more at medicalxpress.com ...
P53 repression is a well known issue, and it's involved in cancers of many different tissues of origin. P53 is the most frequently mutated gene in human cancers.
I look forward to the day when “chemotherapy” is regarded as a horrifyingly barbaric relic of an unenlightened past.
My son has recovered from an unusual cancer of the neck, my brother had an operation for colon cancer and now is receiving chemo for liver metatsteses, and my partner has been treated for prostate cancer with radiation and for another year, anti-testosterone shots. So I have been doing on-line research on cancer and natural treatments.
I had been taking Astaxantin, and other items. to improve my cataracts (successfully). I had also sent some to my brother for his cataracts. Then I read an article which said that astaxantin helps with cancer. It appears it can increase apoptosis (natural cell death) in cancerous tissue while at the same time reducing apoptosis in surrounding normal tissues. So now I am also giving it to my partner.
In 2020 I had learned from Dr. Zelenko that zinc is a virus killer, and that HCQ (an ionophore) helps zinc get into the Covid virus infected cells to destroy the virus. I also learned there were a number of other ionophores (something that changes the electrical charge on the zinc). Ivermectin appears to act as one, and Quercetin, which can be bought without a doctor’s prescription. EGCG and resviritrol seem to also be ionophores and there are more. I then read a science article regarding study of zinc content of nine common cancers. They found that all nine cancer tissues were deficient in zinc, even though surrounding normal tissues were normally or even well supplied with zinc. This article also suggested it might be good to see if an ionophore I had not heard of before might be studied to see if it could get zinc into the cancer virus infected cells. So now I am giving my partner and brother zinc and Quercetin as well as Astaxanthin.
I also read that Vitamin E may interfere with Astaxantin, so I have started taking my Vitamin E in the midday since I take the Astaxantin morning and evening. So much to discover and I am still looking.
My most recent case of COVID included lots of sinus drainage and a tight chest. I was taking a Mucinex product with Dextromethorphan to suppress cough, guaifenesin as an expectorant to thin the mucous and phenylephrine HCL as a nasal decongestion. Recently, I added a supplement containing sulforaphane. It is derived from cruciferous vegetables. The very day I took the first dose of sulforaphane, the tightness in my chest abated. I've taken it daily since and no more need for the Mucinex. Doctor Lynn Fynn had recommended sulforaphane to help the gut/lung "axis". Thus far, I'm getting good results.
where do you get the sulphoraphane?
Amazon stocks it. Natural Grocers has it stocked at a broccoli derived supplement. I misspelled it in my post. Sulforaphane is the correct name.
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