Free Republic

Destroying senescent cells in the aging stem cell niche enhances hippocampal neurogenesis and cognitive function in mice, researchers report. "Our results provide further support for the notion that excessive senescence is a driving factor behind aging, and even late-life reduction of these cells can rejuvenate and restore the function of the stem cell niche," says senior author David Kaplan. "Moreover, they identify stem cells as a key cellular target, potentially explaining the widespread effects of senescent cells on tissue decline." Senescent cells, which are permanently arrested because of chronic stress, are partly responsible for tissue decline during aging. "Stem cells...

I have no idea how 2024 will ultimately play out for Republicans, but I believe if anyone is going to eclipse or defeat Trump, it will be someone like DeSantis who has learned from Trump and could critique him from the right. I wrote about this for Politico today. Ron DeSantis Knows the Formula to Defeat Donald Trump

It was only a matter of time before Ron DeSantis’ rising star ran into the unmovable object of Donald Trump’s will to continue to dominate the GOP. A spate of recent news stories has focused on the proto-feud between the past president with future ambitions, and the protégé who rode his endorsement to victory in a Florida GOP gubernatorial primary and has big ambitions of his own. The scale of the clash shouldn’t be exaggerated — so far it mostly consists of muttering from Mar-a-Lago, and speculation that both men could end up throwing their hats in the 2024 ring....

An investigational cancer drug that starves tumors of their energy supply also shows evidence of improving whole body metabolism, leading to improved weight control, according to a new study. The drug is being investigated for potential use as a treatment for a number of cancers, including sarcoma, breast and pancreatic cancers. The drug breaks down the amino acid arginine in the blood, which deprives cancer cells of a key source of fuel. The researchers became interested in studying the drug after finding that genes responsible for breaking down arginine are dialed up tremendously when the body is in a fasting...

Joe Biden kicked off his presidency on Jan. 20, 2021, by killing the Keystone XL pipeline. It was a message affirming his commitment to green energy policies. For the energy industry, America’s allies abroad and skilled workers at home, however, the impacts of Biden’s actions were far more concrete. “Killing 10,000 jobs and taking $2.2 billion in payroll out of workers’ pockets is not what Americans need or want right now,” Andy Black, president and CEO of the Association of Oil Pipelines, said at the time. “Biden’s hurt us,” said H. Sterling Burnett, Ph.D., Senior Fellow on Environmental Policy for...

Austria's parliament has approved the European Union's strictest Covid-19 vaccine mandate, making it compulsory for the country's residents over the age of 18 to get the shot. The law goes into effect February 1. However, Austrian officials will only begin conducting checks to see if the mandate is being adhered to from March 15. Starting then, those without a vaccine certificate or an exemption could be slapped with initial fines of 600 euro ($680). Pregnant people and those who cannot be vaccinated without endangering their health are exempt from the law, according to the Austrian Health Ministry's website. People who...

Using metal K-wires (commonly known as 'pins') to hold broken wrist bones in place while they heal are no better than a traditional moulded plaster cast. Surgery is expensive and carries risk for the patient, whereas a moulded plaster cast is cheaper but may not provide the same functional outcome. To find out which of these treatments is superior, researchers tracked the progress of 500 adults with a displaced wrist fracture at 36 NHS hospitals between January 2017 and March 2019. Other (secondary) outcomes were PRWE score at three and six months, quality of life, and complications, including the need...

Whether intentional or by accident, China released the China virus on the world causing millions of deaths and enormous economic disaster world-wide...and yet China has made no effort to investigate the incident nor has it made any effort to reimburse the world's nations for the economic losses resulting from the virus release.

Midway through his nearly-two-hour-long news conference on Wednesday, President Joe Biden dropped a very interesting nugget. In talking about his struggles to bring bipartisanship back, Biden recounted that: "I've had five Republican senators talk to me, 'bump into me'— quote, unquote — or sit with me, who've told me that they agree with whatever I'm talking about for them to do. 'But, Joe, if I do it, I'm going to get defeated in a primary.'"

Beginning on January 22, 2022, DHS will require non-U.S. individuals seeking to enter the United States via land ports of entry and ferry terminals at the U.S.-Mexico and U.S.-Canada borders to be fully vaccinated for COVID-19 and provide related proof of vaccination, as COVID-19 cases continue to rise nationwide. These new restrictions will apply to non-U.S. individuals who are traveling for both essential and non-essential reasons. They will not apply to U.S. citizens, Lawful Permanent Residents, or U.S. nationals. “Starting on January 22, 2022, the Department of Homeland Security will require that non-U.S. individuals entering the United States via land...

A speeding motorcyclist who was being tracked by a Los Angeles Police Department helicopter was killed in a brutal head-on crash during the chase. The unidentified cyclist was speeding down Roscoe Boulevard in West Hills, Calif. at about 1 p.m. on Thursday before slamming head-on into a vehicle making a left turn. Cops initially ran the license plate and determined the motorcycle was stolen, LAPD spokesman Sgt. Bruce Borihanh told the Post. The officers then called on an LAPD helicopter to track the motorcyclist, who took off at a high speed.

Higher coffee consumption is linked with a lower risk of endometrial cancer, a type of cancer that begins in the lining of uterus, according to an analysis of relevant studies published to date. Also, caffeinated coffee may provide better protection than decaffeinated coffee. The analysis, which appears in the Journal of Obstetrics and Gynaecology Research, included 24 studies on coffee intake with 9,833 new cases of endometrial cancer occurring in 699,234 individuals. People in the highest category of coffee intake had a 29% lower relative risk of developing endometrial cancer than those in the lowest category. The authors of the...

The Office of Inspector General on Thursday released its findings of misconduct by a senior FBI official for failure to timely report a romantic relationship with a subordinate. The Senior FBI official then lied to the Inspector General about abusing his authority and intimidating a subordinate. “The OIG investigation substantiated the allegations that the Senior Official engaged in a romantic relationship with a subordinate and failed to timely report the relationship, in violation of FBI policy. The OIG also found that the Senior Official violated FBI policy by participating in two hiring or organizational decisions involving the subordinate without receiving...

Francis, the Dictator, Feels “Under Siege”Everything is up in the air, as it has been throughout Francis' pontificate, Specola (InfoVaticana.com, January 18) writes.According to Specola, this shows that Francis feels “under siege” – he doesn’t want anyone to know what he is doing, so, in the “Synodal Church” all decisions are taken by Francis alone while Francis is pretending the contrary.To hide his decisions, Francis appoints commissions with no intention to respect the outcome, so Specola. When the controversies centred around finances, he created two commission (Vatican Bank and the Vatican’s economic-administrative system). Their secret results which were partially leaked...

“That describes what?” Walsh said. “People who identify as a woman,” Addison said. “Identify as what?” Walsh said. “As a woman,” Addison said. “What is that?” Walsh said. Here’s the part on Dr Phil where I demonstrate that the “gender experts” cannot even define the word woman or explain what they mean when they use it pic.twitter.com/7CGcaEUlnj — Matt Walsh (@MattWalshBlog) January 19, 2022 “You won’t even tell me what the word means though, so that’s the problem,” Walsh said. “You want to reduce women, you want to reduce men down to maybe just their genetics, our genitals, our chromosomes,...

Boris Johnson today warned it would be a 'disaster for the world' if Russia invades Ukraine as the nation's president slapped down Joe Biden for 'green-lighting' an attack with his 'minor incursion' gaffe. The UK Prime Minister said 'any kind of incursion, on any scale' would be 'a disaster not just for Ukraine but for Russia' as NATO allies try to dissuade Vladimir Putin from launching an attack the Pentagon warns is 'imminent'. Johnson's remark came after Ukraine's President Volodymyr Zelensky slapped down the US president after he appeared to suggest that a 'minor incursion' by Moscow might elicit a...

CNN is being ridiculed online following the left-wing news network’s new job postings seeking “reality” reporters and an accompanying editor to help combat what it deems “misinformation,” with many noting the hypocrisy of the network having been accused itself of misinformation on many occasions. In the job listing for the “misinformation” team in New York City, CNN Digital states it is seeking “reality” reporters and an editor to help run a “new team covering misinformation,” which the network is starting.

Faithful lay group forms in response to Synodal Path: Church in Germany is ‘on the wrong track’Maria 1.0 is a group of Catholic women working “for the unity of the universal Church and fidelity to the Catholic Magisterium.” (LifeSiteNews) — In light of the very troubling developments in the Catholic Church in Germany and her “Synodal Path,” which is out to question and reform the Church’s long-standing teachings on different topics such as homosexuality, contraception, female ordination and celibacy, a counter-group called Maria 1.0 has been founded.LifeSite reached out to this group in order to get to know them better...

A year into Biden's presidency, we're only burying more overdose victims © U.S. Attorneys Office for Utah via AP, File In 1999, there were just under 20,000 fatal overdoses. Now, overdose deaths are five times higher—over 100,000 in the 12 months ending May 2021, according to the CDC’s most recent, tragically delayed, data. As a member of the 2017 President’s Commission on Combating Drug Addiction and the Opioid Crisis and a national addiction recovery advocate who worked hard to elect the Biden/Harris ticket, respectively, we had front-row seats to the Trump administration’s failure to properly address this crisis. When Joe...

A Florida man has been charged with human smuggling after four people, one an infant, were found dead in a Manitoba field, near the Canada-U.S. border, on Wednesday. "What I am about to share is going to be difficult for many people to hear," RCMP Assistant Commissioner Jane MacLatchy said at a news conference in Winnipeg on Thursday. "It is an absolute and heartbreaking tragedy." The bodies of a man, woman and baby were found together in one area, while the body of a teen boy was found a few metres away, she said. They are believed to have died...